A5100339802- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Poisoning and overdose treatments
- Alcohol Consumption and Health Effects
- Forensic and Genetic Research
- Cerebrovascular and Carotid Artery Diseases
- Forensic Toxicology and Drug Analysis
- Risk Management in Financial Firms
- Adenosine and Purinergic Signaling
- Genomics, phytochemicals, and oxidative stress
- Heat shock proteins research
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Response and Inflammation
- Barrier Structure and Function Studies
- Cardiovascular Effects of Exercise
- Cancer, Stress, Anesthesia, and Immune Response
- Diet and metabolism studies
- Ginger and Zingiberaceae research
China Medical University
2012-2025
Shenzhen University
2024
Liaoning University
2022-2024
Shanghai Jiao Tong University
2023
Institute of Forensic Science
2021
Inner Mongolia Medical University
2017-2019
Foshan Hospital of TCM
2019
Sun Yat-sen University
2019
Second Hospital of Hebei Medical University
2008-2018
Hebei Medical University
2008-2018
Abstract Objective An estimated 200 million patients worldwide have surgery each year. Anesthesia and been reported to facilitate emergence of Alzheimer's disease. The commonly used inhalation anesthetic isoflurane has previously induce apoptosis, increase levels aggregation disease–associated amyloid β‐protein (Aβ) in cultured cells. However, the vivo relevance not addressed. Methods We therefore set out determine effects on caspase activation β‐site precursor protein–cleaving enzyme (BACE)...
<h3>Objective</h3> To assess the effects of sevoflurane, most commonly used inhalation anesthetic, on apoptosis and β-amyloid protein (Aβ) levels in vitro vivo. <h3>Subjects</h3> Naive mice, H4 human neuroglioma cells, cells stably transfected to express full-length amyloid precursor protein. <h3>Interventions</h3> Human were exposed 4.1% sevoflurane for 6 hours. Mice received 2.5% 2 Caspase-3 activation, apoptosis, Aβ assessed. <h3>Results</h3> Sevoflurane induced elevated β-site...
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by accumulation of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein. Accumulating evidence has revealed that slow progressive deterioration AD associated with oxidative stress chronic inflammation in brain. Nuclear factor erythroid 2- (NF-E2-) related 2 (Nrf2), which acts through Nrf2/ARE pathway, a key regulator antioxidant anti-inflammatory response. Although recent data show link between Nrf2...
Abstract Chronic ethanol exposure (CEE), which can lead to neuroinflammation, is an increasing risk factor for depression disorder, but the underlying mechanism not clear. Recent observations have revealed associations among psychiatric disorders, and alterations of gut microbiota. Here, we found that CEE induced depressive-like behavior, could be alleviated by probiotics transferred from donor recipient mice fecal microbiota transplantation (FMT). Neuroinflammation activation NLRP3...
Biomimetic humidity sensors offer a low-power approach for respiratory monitoring in early lung-disease diagnosis. However, balancing miniaturization and energy efficiency remains challenging. This study addresses this issue by introducing bioinspired humidity-sensing neuron comprising self-assembled peptide nanowire (NW) memristor with unique proton-coupled ion transport. The proposed shows low Ag
Increasing evidence indicates that caspase activation and apoptosis are associated with a variety of neurodegenerative disorders, including Alzheimer's disease. We reported anesthetic isoflurane can induce apoptosis, alter processing the amyloid precursor protein (APP), increase amyloid-β (Aβ) generation. However, mechanism by which induces is primarily unknown. therefore set out to assess effects extracellular calcium concentration on isoflurane-induced caspase-3 in H4 human neuroglioma...
Perioperative factors including hypoxia, hypocapnia, and certain anesthetics have been suggested to contribute Alzheimer disease (AD) neuropathogenesis. Desflurane is one of the most commonly used inhalation anesthetics. However, effects desflurane on AD neuropathogenesis not previously determined. Here, we set out assess hypoxia caspase activation, amyloid precursor protein (APP) processing, β-protein (Aβ) generation in H4 human neuroglioma cells (H4 naïve cells) as well those...
Human exposure to inorganic arsenic leads various dermal disorders, including hyperkeratosis and skin cancer. Curcumin is demonstrated induce remarkable antioxidant activity in a variety of cells tissues. The present study aimed at identifying curcumin as potent activator nuclear factor erythroid 2-related 2 (NRF2) demonstrating its protective effect against arsenite- (iAs 3+ -) induced cytotoxicity human keratinocytes. We found that led accumulation NRF2 protein increased the expression...
Ketamine is an injectable anesthetic and recreational drug of abuse commonly used worldwide. Many experimental studies have shown that ketamine can impair cognitive function induce psychotic states. Neuroinflammation has been suggested to play important role in neurodegeneration. Meanwhile, modulate the levels inflammatory cytokines. We hypothesized effects on central nervous system are associated with Therefore, we set out establish acute chronic administration models C57BL/6 mice, evaluate...
Abstract Ethanol, also known as alcohol, is one of the most common drinks in world. Chronic ethanol exposure has been reported to induce mental disorders. Ethanol a strong effect on gut microbiota. The microbiota affect brain via multiple pathways, including changes γ‐aminobutyric acid (GABA) system, and cause variety GABA system cortex associated with anxiety. However, role played exposure‐induced anxiety still not clear. We established 30‐day mouse model investigated effects using...
Chronic ethanol exposure (CEE) is recognized as an important risk factor for depression, and the gut-brain axis has emerged a key mechanism underlying chronic exposure-induced anxiety depression-like behaviors. Short-chain fatty acids (SCFAs), which are metabolites generated by gut microbiota from insoluble dietary fiber, exert protective roles on central nervous system, including reduction of neuroinflammation. However, link between microbial disturbances caused exposure, production SCFAs,...
Tau is known to play an important role in maintaining microtubule assembly and stabilization, the normal morphology of neurons, but several studies have found that chronic stress leads hyperphosphorylation. A large number clinical trials ketamine, which N-methy-D-aspartate receptor antagonist, produces a rapid, long-lasting, potent antidepressant effect patients suffering from major depression. This rapid involves many mechanisms, has attracted wide attention. However, relationship between...
Paraquat (PQ) is a highly toxic herbicide to humans. Pulmonary fibrosis one of the most typical features PQ poisoning, which develops from several days weeks after ingestion. However, mechanism still unclear. In this study, we aimed determine expressions autophagy-related markers Beclin 1, microtubule-associated protein light chain 3 (LC3), and p62 in PQ-poisoned lungs explore role autophagy pulmonary induced by PQ. We detected lung specimens eight fatal cases poisoning hematoxylin eosin...
Probiotics can colonize both the human and animal bodies consist of active microorganisms that are beneficial to health. The use probiotics has been shown alleviate certain neurological diseases disturbances in gut microbiota resulting from chronic ethanol exposure. Research indicates influence nervous system via microbial-gut-brain axis, wherein extracellular vesicles secreted by play a significant role this process. In study, we first established 30-day exposure probiotic gavage mouse...
Brain microvascular endothelial cells (BMECs) are the primary component of blood‑brain barrier (BBB). Tight junction (TJ) proteins, including claudin, occludin and zonula occludens (ZO)‑1, ZO‑2 ZO‑3, maintain structural integrity BMECs. Ethanol activates assembly disassembly TJs, which is a process that regulated by protein kinase C (PKC). In addition, ethanol treatment leads to loss integrity, damages permeability BBB subsequently affects central nervous system homeostasis, thus allowing...