A5100343652- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Visual perception and processing mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Tryptophan and brain disorders
- EEG and Brain-Computer Interfaces
- Neurogenesis and neuroplasticity mechanisms
- Neonatal and fetal brain pathology
- Glycosylation and Glycoproteins Research
- Vagus Nerve Stimulation Research
- Barrier Structure and Function Studies
- Medical Research and Treatments
- Neurological Disorders and Treatments
- Face Recognition and Perception
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neural Engineering
- Cell Adhesion Molecules Research
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
West China Medical Center of Sichuan University
2023-2024
Sichuan Agricultural University
2020-2024
Shaanxi Normal University
2014-2024
Sichuan University
2020-2024
Xian Mental Health Center
2021-2023
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
First Affiliated Hospital of Zhengzhou University
2023
Guangdong Academy of Medical Sciences
2019-2022
Guangdong Provincial People's Hospital
2019-2022
Fisetin, the effective ingredient of traditional Chinese medicine named Cotinus coggygria, is recommended to be active therapeutic in many disorders. However, its role sepsis-associated encephalopathy (SAE) remains unclarified.Cecal ligation and puncture (CLP) operation was performed establish a rat model SAE. Rats were grouped according surgery fisetin administration. Cognitive impairment assessed by Morris water maze test. Disruption blood-brain barrier (BBB) integrity detected Evan's blue...
Abstract This paper presents a grounding protection system of the central solenoid model coil (CSMC) Comprehensive Research Facility for Fusion Technology (CRAFT). The scheme neutral point voltage detections has been adopted in system. Compared with usual current acquisition, measurement data is accurate, there no redundant loop, and economic benefit high. In this paper, single-end double-ends fault superconducting magnet are analyzed, under different conditions calculated. simulation CSMC...
Manipulating neural cell behaviors is a critical issue to various therapies for neurological diseases and damages, where matrix chirality has long been overlooked despite the proven adhesion proliferation improvement of multiple non-neural cells by L-matrixes. Here, it reported that D-matrix specifically enhances density, viability, proliferation, survival in four different types cells, contrasting its inhibition cells. This universal impact on defined as "chirality selection D-matrix"...
Under the conditions of weak basis and reaction temperature range 110-150 °C, lysine, arginine histidine were reacted with L-ascorbic acid at equal amount for 30-150 min, respectively formation browning products was monitored UV–vis spectrometry. The kinetic characteristics their non-enzymatic investigated. study results indicated that these three amino acids to form zero-order reaction. apparent activation energies from acid/lysine, acid/arginine acid/histidine systems 54.94, 50.08...
Abstract Introduction The aim of this study was to explore whether the antibrain edema hypertonic saline (HS) is associated with alleviating ischemic blood‐brain barrier (BBB) permeability by downregulating astrocyte‐derived vascular endothelial growth factor (VEGF), which mediated microglia‐derived NOD‐like receptor protein 3 (NLRP3) inflammasome. Methods infarct volume and BBB were detected. expression level VEGF in astrocytes a transient focal brain ischemia model rats evaluated after 10%...
The ability to discriminate between stimuli relies on a chain of neural operations associated with perception, memory and decision-making. Accumulating studies show learning-dependent plasticity in perception or decision-making, yet whether perceptual learning modifies mnemonic processing remains unclear. Here, we trained human participants both sexes an orientation discrimination task, while using functional magnetic resonance imaging (fMRI) transcranial stimulation (TMS) separately examine...
The efficacy of electrical stimulation facilitating peripheral nerve regeneration is evidenced extensively, while the associated secondary damage resulting from repeated electrode invasion and indiscriminate inevitable. Here, we present an optogenetics strategy that utilizes upconversion nanoparticles (UCNPs) to convert deeply penetrating near-infrared excitation into blue emission, which activates adeno-associated virus-encoding ChR2 photoresponsive ion channel on cell membranes. induced Ca
Refractory hypoxemia is the main symptom of acute respiratory distress syndrome (ARDS). Low tidal volume ventilation routinely applied in clinical practice to correct hypoxemia, which aims prevent ventilator‑induced lung injury. However, this strategy inevitably leads hypercapnia. Our previous study demonstrated that hypercapnia aggravated cognitive impairment hypoxemic rats; however, underlying mechanism remains unclear. The aim present was investigate whether exacerbates blood‑brain...
A simple and general method for detecting protein tyrosine kinase activity is developed based on a tyrosinase-assisted fluorescence turn-on strategy.
Stroke is a life-threatening disease with limited therapeutic options. Damage to the blood-brain barrier (BBB) key pathological feature of ischemic stroke. This study explored role bradykinin (BK)/bradykinin 1 receptor (B1R) and its mechanism action in BBB. Human brain microvascular endothelial cells (BMECs) were used test for cellular responses BK by using Cell Counting Kit-8 assay, 5-ethynyl-2'-deoxyuridine staining, enzyme-linked immunosorbent flow cytometry, immunofluorescence,...
The responses of cortical neurons to a stimulus in classical receptive field (CRF) can be modulated by stimulating the non-CRF (nCRF) primary visual cortex (V1). In very early stages (at around 40 ms), neuron V1 exhibits strong small set stimuli. Later, however (after 100 become sensitive scene's global organization. As per these mechanisms, contour detection model based on spatial summation properties is proposed. Unlike previous studies, nCRF higher that results inhibition neuronal...
Contour integration is a critical step in visual perception because it groups discretely local elements into perceptually global contours. Previous investigations have suggested that striate and extrastriate areas are involved this mid-level processing of perception. However, the temporal dynamics these human brain during contour less understood. The present study used functional magnetic resonance imaging-guided transcranial stimulation (TMS) to briefly disrupt 1 2 (V1/V2 V3B) examined...
Previous studies have reported the potential developmental neurobehavioral effects of decabrominated diphenyl ethers (BDE 209) on developing animals, but adult animals are rare or controversial and mechanism is not fully understood. In present study, male Sprague-Dawley rats performed poor spatial learning memory in Morris water maze after exposure to BDE 209 by gavage for 30 days. The expression hippocampal glutamate receptor subunits NR1, NR2B GluR1, phosphorylation subunit at Ser1301...
Previous literature suggests that low-level stimulus properties determine the detection performance of contours and are used to define different contour types. Here we investigated processing types under conscious unconscious conditions. In Experiment 1, adopted an inattentional blindness paradigm showed collinear (i.e., a type is frequently observed in natural images) induced positive cuing effect both conditions, whereas orthogonal (which less prevalent environment) attracted attention...
Music can express people’s thoughts and emotions. therapy is to stimulate hypnotize the human brain by using various forms of music activities, such as listening, singing, playing rhythm. With empowerment artificial intelligence, technology has made innovative development in whole process “diagnosis, treatment evaluation.” It necessary make use advantages intelligence innovate methods, ensure accuracy schemes, provide more paths for medical field. This paper proposes an long short-term...
Dynamically evaluating the outcomes of our actions and thoughts is a fundamental cognitive ability. Given its excellent temporal resolution, event-related potential (ERP) technology has been used to address this issue. The feedback-related negativity (FRN) component ERPs studied intensively with averaged linked mastoid reference method (LM). However, it unknown whether FRN can be induced by an expectancy violation in antonym relations context LM most suitable approach. To these issues,...