A5074878567- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Engineering Education and Curriculum Development
- Neuroscience and Neuropharmacology Research
- Education and Work Dynamics
- Cancer-related Molecular Pathways
- Parkinson's Disease Mechanisms and Treatments
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Innovative Educational Techniques
- Metabolomics and Mass Spectrometry Studies
- Wnt/β-catenin signaling in development and cancer
- Ideological and Political Education
- Hippo pathway signaling and YAP/TAZ
- Hydrogen's biological and therapeutic effects
- Information Systems and Technology Applications
- Cancer Cells and Metastasis
- Curcumin's Biomedical Applications
- Vibration and Dynamic Analysis
- Anesthesia and Neurotoxicity Research
- Barrier Structure and Function Studies
- Neurological diseases and metabolism
- Metallurgical Processes and Thermodynamics
Southwest Medical University
2011-2025
China West Normal University
2024
Hua Medicine (China)
2011
University of Electronic Science and Technology of China
2011
First Affiliated Hospital of Sichuan Medical University
2008
Tsinghua University
1988
Abstract The hypoxic tumor microenvironment (TME) significantly affects cancer treatment. Conventional chemotherapeutic agents cannot effectively target tissue, which decreases efficacy and results in severe toxic side effects. To alleviate this problem, a self‐driving biomotor is developed by functionalizing MCDP nanoparticles containing calcium peroxide doxorubicin (DOX) loaded onto polydopamine‐coated metal–organic frameworks（MOF）, with the anaerobic Bifidobacterium infantis (Bif) for...
Due to oral nano-delivery systems for the treatment of inflammatory bowel disease (IBD) are often failed accumulated colonic site and could not achieve controlled drug release, it's urgent develop a microenvironment responsive delivery improve therapy efficacy. Inflammation at IBD is mainly mediated by macrophages, which key effector cells. Excessive inflammation leads oxidative stress intestinal mucosal damage. The use curcumin (CUR) emodin (EMO) together promising due their respective...
Globally, breast cancer stands as the most prevalent form of among women. The tumor microenvironment often exhibits hypoxia. Hypoxia-inducible factor 1-alpha, a transcription factor, is found to be overexpressed and activated in cancer, playing pivotal role anoxic by mediating series reactions. 1-alpha involved regulating downstream pathways target genes, which are crucial hypoxic conditions, including glycolysis, angiogenesis, metastasis. These processes significantly contribute progression...
Abstract Background Hypoxia is a frequent characteristic observed in solid tumors and strongly associated with tumor metastasis, angiogenesis, drug resistance. While the vasculature of hypoxic tissues poses obstacles to efficient administration conventional drugs, it may prove advantageous sustaining hyperthermia. Photothermal therapy (PTT) offers promising treatment strategy that utilizes activation photosensitizers produce heat, thus facilitating selective ablation tissues. Method To...
Background: Breast cancer (BC) has become the main malignant tumor threatening health of women worldwide. Previous studies have reported that Lactate dehydrogenase-A (LDHA) critical roles in development and progression. We aimed to explore LDHA LDH5 isoenzyme activity BC, which provides a new insight into for treatment BC. Methods: The expression BC its relationship with clinicopathological features were obtained from various databases including Cancer Genome Atlas (TCGA), Human Protein...
Breast cancer is characterized by insidious onset, rapid progression, easy recurrence, and metastasis. Conventional monotherapies are usually ineffective due to insufficient drug delivery. Therefore, the combination of multimodal therapy with tumor microenvironment (TME)-responsive nanoplatforms increasingly being considered for targeted treatment breast cancer. We synthesized bioactive hybrid nanoparticles synergistic chemotherapy photothermal therapy. Briefly, doxorubicin (DOX) indocyanine...
Acrylamide (ACR) is a common chemical used in various industries and it said to have chronic neurotoxic effects. It produced during tobacco smoking also generated high-starch foods heat processing. Notoginsenoside R1 (NR1) traditional Chinese medicine, which improve the blood circulation clotting. The objective of this study was investigate mechanism ACR-triggered neurotoxicity identify protective role NR1 by upregulating thioredoxin-1 (Trx-1). Our results shown that could block spatial...
Lactate dehydrogenase A (LDHA) primarily catalyzes the conversion between lactic acid and pyruvate, serving as a key enzyme in aerobic glycolysis pathway of sugar tumor cells. LDHA plays crucial role occurrence, development, progression, invasion, metastasis, angiogenesis, immune escape tumors. Consequently, not only serves biomarker for diagnosis prognosis but also represents an ideal target therapy. Although inhibitors show great therapeutic potential, their development has proven to be...
Previous studies have reported the potential developmental neurobehavioral effects of decabrominated diphenyl ethers (BDE 209) on developing animals, but adult animals are rare or controversial and mechanism is not fully understood. In present study, male Sprague-Dawley rats performed poor spatial learning memory in Morris water maze after exposure to BDE 209 by gavage for 30 days. The expression hippocampal glutamate receptor subunits NR1, NR2B GluR1, phosphorylation subunit at Ser1301...
The study, investigated in Luzhou Medical College, aims to find out whether the use of Multimedia Monitoring System is more effective for medical teachers' training on teaching ability compared full-time teaching. Two groups teachers have been involved study. first group has allowed practice skills through micro-teaching with aid System. second practices their own but without At end we discover that which used made significant progress mastery skills.
As an important enzyme for energy metabolism, lactate dehydrogenase (LDH) and its isoenzymes (LDH isoenzymes) have been extensively studied.