A5103114389- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- MicroRNA in disease regulation
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Cell death mechanisms and regulation
- Ultrasound and Hyperthermia Applications
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- Immune cells in cancer
Affiliated Hospital of Southwest Medical University
2017-2025
Southwest Medical University
2009-2025
Sichuan Cancer Hospital
2025
Sichuan University
2025
First Affiliated Hospital of Sichuan Medical University
2009-2022
Abstract The hypoxic tumor microenvironment (TME) significantly affects cancer treatment. Conventional chemotherapeutic agents cannot effectively target tissue, which decreases efficacy and results in severe toxic side effects. To alleviate this problem, a self‐driving biomotor is developed by functionalizing MCDP nanoparticles containing calcium peroxide doxorubicin (DOX) loaded onto polydopamine‐coated metal–organic frameworks（MOF）, with the anaerobic Bifidobacterium infantis (Bif) for...
This study prepared a composite scaffold composed of curcumin and poly(ε‐caprolactone)‐poly(ethylene glycol)‐poly(ε‐caprolactone) (PCL‐PEG‐PCL, PCEC) copolymer using coelectrospinning technology. Incorporation into the polymeric matrix had an obvious effect on morphology dimension PCEC/curcumin fibers. The results in vitro anti‐oxidant tests cytotoxicity assay demonstrated that curcumin‐loaded PCEC fibrous mats significant efficacy low cytotoxicity. Curcumin could be sustainably released...
Regorafenib is a potent multikinase inhibitor for the second-line targeted therapy against hepatocellular carcinoma (HCC); however, drug resistance emerging in clinical settings. Although cancer stem cells (CSCs) are considered as key determinate of sensitivity, it remains unclear how CSCs may communicate with differentiated counterparts (non-CSC) to dictate therapeutic efficacy. Therefore, we sought investigate regorafenib mechanism HCC.We used sphere formation and soft agar colony assays...
Background: Chemotherapy still plays a dominant role in cancer treatment. However, the inability of conventional chemotherapeutic drugs to reach hypoxic zone solid tumors significantly weakens their efficacy. Bacteria-mediated drug delivery systems can be an effective targeting strategy for improving therapeutic outcomes cancer. Anaerobic bacteria have unique ability selectively transport loads regions tumors. Methods: We designed Bifidobacterium infantis (Bif)-based biohybrid ( [email...
Anlotinib, a tyrosine kinase inhibitor, has shown encouraging antitumor activity in platinum-resistant/refractory ovarian cancer. The efficacy of anlotinib as maintenance therapy advanced cancer remains unclear. Therefore, we designed this study to evaluate the and safety following first-line treatment with paclitaxel platinum-based chemotherapy In single-arm, phase II clinical trial, patients newly diagnosed were received monotherapy once after response until tumor progression or...
Anlotinib is a highly potent multi-target tyrosine kinase inhibitor, with very good anti-tumor activity against variety of solid tumors. However, its effect on colorectal cancer (CRC) not yet clearly understood. The objective this study was to investigate the and underlying mechanism anlotinib in pathogenesis CRC.Effects CT26 cells proliferation microvessel formation endothelial were determined by MTT assay tube assay. Cell migration invasion analyzed using wound healing transwell cycle...
Chemotherapy is one of the main therapeutic strategies for treatment malignant melanoma. Conventional chemotherapeutic agents often lack targeting abilities, and efficacy hampered by their high toxic effects to normal tissues rapid clearance from circulation. In this study, porous paclitaxel (PTX)-loaded polylactide (PLA) microspheres (PPMSs) were prepared a modified double-emulsion-solvent evaporation method. addition, PPMSs cisplatin (DDP) co-embedded in thermosensitive hydrogel construct...
The purpose of this paper is to determine the efficacy combining radiation therapy with endostar, a recombined humanized endostatin, in human nasopharyngeal carcinoma and lung adenocarcinoma xenografts. Tumor xenografts were established hind limb male athymic nude mice (BALB/c-nu) by subcutaneous transplantation. tumor-bearing assigned into four treatment groups: sham (control), endostar (20 mg/kg, once daily for 10 days), (6 Gray per day 30 Gray, 1 week), plus (combination). experiment was...
The purpose of this study was to prepare ES-loaded chitosan nanoparticles (ES-NPs) and evaluate the antitumor effect these particles on Lewis lung cancer model. ES-NPs were prepared by a simple ionic cross-linking method. characterization ES-NPs, including size distribution, zeta potential, loading efficiency encapsulation (EE), performed. An in vitro release test also used determine behavior ES-NPs. Cell viability cell migration assayed detect antiangiogenic In order clarify vivo, model...
The purpose of this study was to prepare endostatin-loaded chitosan nanoparticles (ES-NPs) and evaluate their antitumor effect when combined with paclitaxel (PTX) on Lewis lung carcinoma (LLC) mouse xenografts. ES-NPs were prepared by ionic cross-linking. Characterization the included size distribution, drug-loading efficiency (DL), encapsulation (EE). An in vitro release test also used determine behavior ES-NPs. A subcutaneous LC xenograft model C57BL/6J mice established. randomly divided...
The effect of apatinib on the formation vasculogenic mimicry (VM) was studied in a malignant melanoma cell line. MUM-2B cells cultured three-dimensional Matrigel were treated with varying concentrations (0, 0.01, 0.05, 0.1, 0.5 μmol/L) to test its VM vitro, followed by MTT proliferation and transwell invasion assays determine cells. In vivo, we used cancer model short-term (100, 200, 300 mg/kg) treatment VM. Western blotting, immunohistochemistry staining, CD31-PAS dual staining performed...
Aim: To explore the role of adenylyl cyclase isoforms and its epigenetics in cancer. Materials & methods: Adenylyl expression profiles, epigenetic alterations, prognostic value molecular networks were assessed by use public omics datasets. Results: ADCY4 was significantly downregulated breast This downregulation associated with promoter hypermethylation. High correlated better survival patients cancer different intrinsic subtypes tumor stages. shown to be strongly G protein coupled receptors...
Vascular endothelial growth factor (VEGF) is a critical regulator of malignant pleural effusion (MPE) in non-small-cell lung cancer (NSCLC). Bevacizumab (BEV) and apatinib (APA) are novel VEGF blockers that inhibit cell proliferation the development effusion.In this study, we established Lewis (LLC) xenograft mouse models to compare therapeutic effect APA BEV combination with cisplatin (CDDP) against MPE. The anti-tumour anti-angiogenic effects therapy were evaluated by 18F-FDG PET/CT...
Scaffolds for bone tissue engineering applications should have suitable degradability in favor of new ingrowth after implantation into defects. In this study, degradation behavior polyurethane composites composed triblock copolymer poly(caprolactone)-poluronic-poly(caprolactone) (PCL-Pluronic-PCL, PCFC) and nanohydroxyapatite (n-HA) was investigated. The water contact angle absorption were measured to reveal the effect n-HA content on surface wettability swelling n-HA/PCFC composites,...
The TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target gene, which functions to suppress reactive oxygen species (ROS) damage protect cells from apoptosis. In this study, we investigated the role of TIGAR in nasopharyngeal carcinoma (NPC) tumorigenesis. Imnunohistochemical analysis tissue specimens patients showed higher expression level tumor tissues, compared with normal epithelium. Knockdown by lentivirus-shRNA CNE-2 or 5-8F resulted decreased cell growth, colony...
This study aimed to develop an effective therapy against M2 macrophages and investigate the effects of imidazole mannose modified carboxymethyl chitosan-nanoparticles (MIC-NPs) on tumor growth antitumor immune responses. MIC-NPs were constructed analyzed through 1H NMR, nano-laser particle size analyzer, transmission electron microscopy. The nanoparticles mainly distributed in 75–85 nm, zeta potential was 1.5 mV. Cytotoxicity studies vitro vivo indicated that safe. targeting effect observed...