A5012949859- Bioinformatics and Genomic Networks
- Cutaneous Melanoma Detection and Management
- Cancer-related molecular mechanisms research
- Melanoma and MAPK Pathways
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Cells and Metastasis
- interferon and immune responses
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- melanin and skin pigmentation
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Inflammatory Biomarkers in Disease Prognosis
- Endometrial and Cervical Cancer Treatments
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related Molecular Pathways
- vaccines and immunoinformatics approaches
- Circular RNAs in diseases
- Poxvirus research and outbreaks
- Sirtuins and Resveratrol in Medicine
- Synthesis and biological activity
- Inflammasome and immune disorders
Southwest Medical University
2023-2025
Islamic Azad University Medical Branch of Tehran
2021-2023
University of Tehran
2015-2023
Tehran University of Medical Sciences
2022
Breast cancer (BC) is the most common tumor in women worldwide. TRIM28 (RNF96) plays pleiotropic biological functions, such as silencing target genes, facilitating DNA repair, stimulating cellular proliferation and differentiation, contributing to progression. an increasingly crucial role cancer, but its impact on BC, including breast invasive carcinoma, remains poorly understood. In current study, analyses of online databases, quantitative real-time PCR, immunohistochemistry, western...
Abstract Background asthma, chronic obstructive pulmonary disease (COPD), and idiopathic fibrosis (IPF) are three serious diseases that contain common unique characteristics. Therefore, the identification of biomarkers differentiate these is importance for preventing misdiagnosis. In this regard, present study aimed to identify disorders at early stages, based on lung transcriptomics data drug-target interactions. Methods To end, differentially expressed genes were found in each disease....
Lung cancer is the most common in men and women. This divided into two main types, namely non-small cell lung (NSCLC) small (SCLC). Around 85 to 90 percent of cancers are NSCLC. Repositioning potent candidate drugs NSCLC treatment one important topics studies. Drug repositioning (DR) or drug repurposing a method for identifying new therapeutic uses existing drugs. The current study applies computational identify treat patients. To this end, at first, transcriptomics profile healthy (control)...
Vascular endothelial growth factor (VEGF) is a critical regulator of malignant pleural effusion (MPE) in non-small-cell lung cancer (NSCLC). Bevacizumab (BEV) and apatinib (APA) are novel VEGF blockers that inhibit cell proliferation the development effusion.In this study, we established Lewis (LLC) xenograft mouse models to compare therapeutic effect APA BEV combination with cisplatin (CDDP) against MPE. The anti-tumour anti-angiogenic effects therapy were evaluated by 18F-FDG PET/CT...
Membrane transporters are proteins responsible for facilitating the movement of molecules within biological membranes. They play a vital role in maintaining cellular homeostasis by regulating transport nutrients, ions, and other into out cells. Our aim is to identify biomarkers colorectal cancer using membrane transporter proteins. We utilized COAD TCGA data this purpose. Subsequently, we conducted differential gene analysis feature selection Furthermore, identified two potential genes,...
The present study assessed the use of filters for noise reduction in ultrasound images common carotid artery (CCA) and brachial using intima–media thickness, which is a safe non‐invasive technique determining subclinical atherosclerosis cardiovascular risk. A new combined speckle reducing anisotropic diffusion (SRAD) filter then proposed. Ultrasonic examination both arteries was performed on 30 men (aged 40 ± 5 years). programme designed MATLAB software to extract consecutive bit map format...
To discover vulnerabilities associated with dermokine (DMKN) as a new trigger of the epithelial-mesenchymal transition (EMT) -driven melanoma, we undertook genome-wide genetic screening using transgenic. Here, showed that DMKN expression could be constitutively increased in human malignant melanoma (MM) and this correlates poor overall survival patients, especially BRAF-mutated MM samples. Furthermore, vitro , knockdown inhibited cell proliferation, migration, invasion, apoptosis cancer...
Abstract BRAF and NRAS are the most reported mutations associated to melanomagenesis. The lack of accurate diagnostic markers in response therapeutic treatment BRAF/NRAS-driven melanomagenesis is one main challenges melanoma personalized therapy. In order assess value phosphatidylserine-specific phospholipase A1-alpha (PLA1A), a potent lysophospholipid mediating production lysophosphatidylserine, PLA1A mRNA serum levels were compared subjects with malignant (n = 18), primary 13), healthy...
The genome‑wide copy number analysis of circulating tumor cells (CTCs) provides a promising prognostic biomarker for survival in breast cancer liver metastasis (BCLM) patients. present study aimed to confirm the value presence CTCs BCLM We previously developed an assay pattern differences variations (CNVs) as adjunct test routine imaging and histopathologic diagnosis methods distinguish newly diagnosed metastases recurrent metastases. Forty‑three patients were selected this which 23 20 by...
Hereditary hemorrhagic telangiectasia (HHT), also called Rendu-Osler syndrome, is a group of rare genetic diseases characterized by autosomal dominance, multisystemic vascular dysplasia, and age-related penetrance. This includes arteriovenous malformations (AVMs) in the skin, brain, lung, liver, mucous membranes. The correlations between phenotype genotype for HHT are not clear. An Chinese pedigree was recruited. Whole exome sequencing (WES) analysis, Sanger verification, co-segregation were...
Monkeypox (Mpox) is a growing public health concern, with complex interactions within host systems contributing to its impact. This study employs multi-omics approaches uncover therapeutic targets and potential drug repurposing opportunities better understand Mpox's molecular pathogenesis. We developed an in silico host-pathogen interaction (HPI) network applied weighted gene co-expression analysis (WGCNA) explore between Mpox proteins. Subtype-specific protein-protein networks were...
This study aimed to identify a novel disease-associated differentially co-expressed mRNA-microRNA (miRNA) that is associated with vasculogenic mimicry (VM) and epithelial-to-mesenchymal transition (EMT) network at different stages of melanoma. By applying weighted gene co-expression analysis, we constructed VM+EMT biological the available microarray dataset downloaded from public database. Quantitative real-time PCR, immunohistochemical staining, CD31-periodic acid solution dual staining...