A5102644424- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Bone and Joint Diseases
- Cancer Cells and Metastasis
- Hematopoietic Stem Cell Transplantation
- Angiogenesis and VEGF in Cancer
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
- Cancer Immunotherapy and Biomarkers
- Cellular Mechanics and Interactions
- Sarcoma Diagnosis and Treatment
- Engineering Technology and Methodologies
- Renal and related cancers
- Cell death mechanisms and regulation
- Animal testing and alternatives
- Mechanical Systems and Engineering
- Hepatocellular Carcinoma Treatment and Prognosis
Affiliated Hospital of Southwest Medical University
2016-2024
Sichuan University
2023
West China Hospital of Sichuan University
2023
Kunming Medical University
2019
First Affiliated Hospital of Kunming Medical University
2019
Tianjin Medical University General Hospital
2011
Tianjin Medical University
2011
Chinese Academy of Medical Sciences & Peking Union Medical College
2008
Abstract Background Mesenchymal stem cells are heterogenous populations with hematopoietic supporting and immunomodulating capacities. Enormous studies have focused on their preclinical or clinical therapeutic effects, yet the systematic study of continuous in vitro passages signatures functions UC-MSCs at both cellular molecular levels is still lacking. Methods In this study, to systematically evaluate biological properties MSCs various passages, we analyzed biomarker expression, cell...
State-of-the-art advances have indicated the pivotal characteristics of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) in hematopoietic microenvironment as well coordinate contribution to hematological malignancies. However, panoramic view and detailed dissection BM-MSCs patients with acute myeloid leukemia (AML-MSCs) remain obscure. For purpose, we isolated identified AML-MSCs together healthy donor-derived HD-MSCs from marrow mononuclear (BM-MNCs) by using standard density...
Background Treatment of ER + breast cancer with intramuscular formulation Formestane (4-OHA) shrinks the tumor within weeks. Since tedious way administration and side effects are not suited for adjuvant treatment, was withdrawn from market. A new transdermal 4-OHA cream may overcome defects retain effect shrinking tumor. However, on need further confirmatory studies. Methods In this work, in vivo , influence evaluated using mode 7,12-dimethylbenz(a)anthracene (DMBA) induced rat mammary...
The genome‑wide copy number analysis of circulating tumor cells (CTCs) provides a promising prognostic biomarker for survival in breast cancer liver metastasis (BCLM) patients. present study aimed to confirm the value presence CTCs BCLM We previously developed an assay pattern differences variations (CNVs) as adjunct test routine imaging and histopathologic diagnosis methods distinguish newly diagnosed metastases recurrent metastases. Forty‑three patients were selected this which 23 20 by...
Abstract Circulating tumor cells (CTCs) indicate the diagnosis and prognosis of cancer patients, together with benefiting individual treatment anticancer drug development. However, their large‐scale application in general population still requires systematically multifaceted modifications for currently proprietary new technologies based on filtration. We primitively utilized a cell size‐based platform to evaluate recovery efficiency spiked abnormal lines analyzed circulating (CACs). To...
Objectives To investigate the role of immune escape encoding genes on prognosis BC, and to predict novel targeting agents. Methods Human were obtained from IMMPORT database previous study. Sample information clinical data BC TCGA GTEX databases. Obtaining differentially expressed protein cBioportal database. construct a risk score model by lasso analysis, nomogram was used core. GSCA, TIMER CELLMINER databases for drug susceptibility correlation analyses. Cell experiments verified MTT,...
Abstract Background Whole-genome doubling (WGD) has been observed in 30% of cancers, followed by a highly complex rearranged karyotype unfavourable to breast cancer's outcome. However, the macro-alterations that characterise liver metastasis cancer(BC) are poorly understood. Here, we conducted whole-genome sequencing analysis metastases explore status and time frame model these pre-treatment patients with metastatic cancer. Results was 11 paired primary tumours, lymph node metastasis, fresh...
Formestane (4-OHA) has been proven to be highly effective with high systemic tolerability in treating ER+ breast cancer. However, its intramuscular administration and associated side effects make it unsuitable for adjuvant treatment, leading withdrawal from the market. In contrast, cream may offer a solution by providing more convenient route of retaining tumor-shrinking effects. This suggests that 4-OHA could have promising clinical applications. before application, is necessary evaluate...