A5103080545- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Parkinson's Disease Mechanisms and Treatments
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Renin-Angiotensin System Studies
- Per- and polyfluoroalkyl substances research
- Zebrafish Biomedical Research Applications
- Neurological disorders and treatments
- Liver Diseases and Immunity
- Hormonal Regulation and Hypertension
- Circular RNAs in diseases
Kunming Medical University
2014-2025
First Affiliated Hospital of Kunming Medical University
2012-2025
Xian Yang Central Hospital
2024
Beijing Research Center for Agricultural and Standards and Testing
2023
National Institute on Drug Abuse
2013-2022
Second People's Hospital of Yunnan Province
2022
Ministry of Agriculture and Rural Affairs
2019-2021
Beijing Municipal Ecological and Environmental Monitoring Center
2021
Affiliated Hospital of Southwest Medical University
2019
Institute of Pomology
2018
Orexin‐containing neurons have been implicated in feeding, sleep–wake cycles and more recently drug‐seeking behaviour. Pretreatment of alcohol‐preferring (iP) rats with an orexin 1 receptor antagonist (SB‐334867, 20 mg kg −1 , intraperitoneally) completely abolished olfactory cue‐induced reinstatement alcohol‐seeking behaviour, also attenuated alcohol responding under operant fixed ratio regimen without affecting water responding. The mRNA encoding within the hypothalamus was expressed at a...
Abstract Gut bacteriome dysbiosis is known to be implicated in the pathogenesis of inflammatory bowel disease (IBD). Crohn’s (CD) an IBD subtype with extensive mucosal inflammation, yet virome, empirical modulator and immunity, remains largely unclear regarding its composition role. Here, we exploited trans-cohort CD patients healthy individuals compositionally functionally investigate small (terminal ileum) virome bacteriome. The ileal was characterised by under-representation both lytic...
Abstract We have recently reported the expression of functional cannabinoid CB 2 receptors (CB Rs) in midbrain dopamine (DA) neurons mice. However, little is known whether Rs are similarly expressed rat brain because significant species differences R structures and found. In situ hybridization immunohistochemical assays detected gene DA ventral tegmental area (VTA), which was up‐regulated cocaine self‐administration rats. Electrophysiological studies demonstrated that activation by JWH133...
Abstract Background Mesenchymal stem cells are heterogenous populations with hematopoietic supporting and immunomodulating capacities. Enormous studies have focused on their preclinical or clinical therapeutic effects, yet the systematic study of continuous in vitro passages signatures functions UC-MSCs at both cellular molecular levels is still lacking. Methods In this study, to systematically evaluate biological properties MSCs various passages, we analyzed biomarker expression, cell...
C57BL/6 mice were given 0.2% cuprizone (CPZ) for 2 to 6 weeks while controls ate the same diet without CPZ. At various time points animals subjected behavioral tests and their brains analyzed. Mice exposed CPZ 3 displayed more climbing behavior lower prepulse inhibition, suggesting an increase in central nervous system activity impaired sensorimotor gating. In addition, they showed activities of monoamine oxidase dopamine beta hydroxylase hippocampus prefrontal cortex, had higher but...
// Hongju Yang 1,* , Qian Li 2,* Jie Niu 3,* Bai 2 Dejun Jiang 1 Zhihua Wan Qingmei Fei Ping Wei and Song The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China Human Genetics Center Yunnan 3 Institute Medicinal Biology Chinese Academy Science, * These authors have contributed equally to this work Correspondence to: Bai, email: Keywords : NAA10, miR-342-5p, miR-608, colon cancer Received June 03, 2015 Accepted October 14, Published December 04, Abstract miRNAs...
Recent animal and human studies have suggested that the cuprizone (CPZ, a copper chelator)-fed C57BL/6 mouse may be used as an model of schizophrenia. The goals this study were to see recovery processes CPZ-induced behavioral changes damaged white matter examine possible effects antipsychotic drugs on processes. Mice fed CPZ-containing diet for 5 weeks then returned normal food 3 weeks, during which period mice treated with different drugs. Various behaviors measured at end CPZ-feeding phase...
Abstract Pre‐clinical studies suggest that negative allosteric modulators ( NAMs ) of the metabotropic glutamate receptor subtype 5 mGluR5 ), including 2‐methyl‐6‐(phenylethynyl)pyridine MPEP 3‐[(2‐methyl‐1,3‐thiazol‐4‐yl)ethynyl]pyridine MTEP and fenobam are highly effective in attenuating drug‐taking drug‐seeking behaviors. However, both have no translational potential for use humans because their off‐target effects short half‐lives. Here, we report...
The development of rapid and safe antidepressants for the treatment major depression is in urgent demand. Converging evidence suggests that glutamatergic signaling seems to play important roles pathophysiology depression. We studied antidepressant effects 3'-deoxyadenosine (3'-dA, Cordycepin) critical role α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor male CD-1 mice via behavioral biochemical experiments. After 3'-dA treatment, phosphorylation synaptic localization...
It is well established that glutamate plays an important role in drug-induced and cue-induced reinstatement of drug seeking. However, the reward unclear. In this study, we systemically evaluated effects multiple transporter (GLT) inhibitors on extracellular dopamine (DA) nucleus accumbens (NAc), intravenous cocaine self-administration, intracranial brain-stimulation (BSR), seeking male female rats. Among five GLT tested, TFB-TBOA was most potent. Microinjections into NAc, but not ventral...