A5101620441- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Cholinesterase and Neurodegenerative Diseases
- Cannabis and Cannabinoid Research
- Epilepsy research and treatment
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Photoreceptor and optogenetics research
- Cardiac Ischemia and Reperfusion
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Insect and Pesticide Research
- Circular RNAs in diseases
Shantou University
2016-2025
Shantou University Medical College
2016-2025
Guangxi Medical University
2025
St. Joseph's Hospital and Medical Center
2014-2024
Barrow Neurological Institute
2014-2024
First Affiliated Hospital of Shantou University Medical College
2023-2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Qingdao University
2016-2024
First Affiliated Hospital of Zhengzhou University
2016-2024
Significance Although early studies suggested that cannabinoid CB 2 receptors (CB Rs) are absent in the brain, this view has been challenged by recent findings of significant brain R involvement several dopamine (DA)-related CNS disorders. The cellular mechanisms underlying these actions unclear, however. Using multiple approaches, we found genes and expressed midbrain DA neurons, activation Rs inhibits neuronal firing i.v. cocaine self-administration. These not only challenge long-held but...
Diethylstilbestrol (DES) is a nonsteroidal estrogen that induces developmental anomalies of the female reproductive tract. The homeobox gene HOXA10 controls uterine organogenesis, and its expression altered after in utero DES exposure. We hypothesized an epigenetic mechanism underlies DES-mediated alterations expression. analyzed pattern methylation profile Expression increased human endometrial cells exposure, whereas Hoxa10 repressed shifted caudally from normal location mice exposed...
Nicotinic acetylcholine receptors (nAChRs) containing α7 subunits are thought to assemble as homomers. α7-nAChR function has been implicated in learning and memory, alterations of have found patients with Alzheimer's disease (AD). Here we report findings consistent a novel, naturally occurring nAChR subtype rodent, basal forebrain cholinergic neurons. In these cells, coexpressed, colocalize, coassemble β2 subunit(s). Compared homomeric α7-nAChRs from ventral tegmental area neurons,...
Histone deacetylase 6 (HDAC6) is currently being discussed as a promising therapeutic target for the treatment of Alzheimer's disease (AD). Mounting evidence indicates that increased HDAC6 expression may contribute to AD-associated neurodegeneration, although beneficial effects have also been identified. In present study, we tested potential two selective inhibitors, tubastatin A and ACY-1215, rescue cognitive deficits in mouse model AD. We found both ACY-1215 alleviated behavioral deficits,...
Abstract We have recently reported the expression of functional cannabinoid CB 2 receptors (CB Rs) in midbrain dopamine (DA) neurons mice. However, little is known whether Rs are similarly expressed rat brain because significant species differences R structures and found. In situ hybridization immunohistochemical assays detected gene DA ventral tegmental area (VTA), which was up‐regulated cocaine self‐administration rats. Electrophysiological studies demonstrated that activation by JWH133...
Abstract Background Although evidence suggests that the prevalence of Parkinson’s disease (PD) is lower in smokers than non-smokers, mechanisms nicotine-induced neuroprotection remain unclear. Stimulation α7 nicotinic acetylcholine receptor (α7-nAChR) seems to be a crucial mechanism underlying anti-inflammatory potential cholinergic agonists immune cells, including astrocytes, and inhibition astrocyte activation has been proposed as novel strategy for treatment neurodegenerative disorders...
Aging is the most important risk factor associated with Alzheimer's disease (AD); however, molecular mechanisms linking aging to AD remain unclear. Suppression of ribosomal protein S6 kinase 1 (S6K1) increases healthspan and lifespan in several organisms, from nematodes mammals. Here we show that S6K1 expression upregulated brains patients. Using a mouse model AD, found genetic reduction improved synaptic plasticity spatial memory deficits, reduced accumulation amyloid-β tau, two...
A case-control study is presented.To investigate the association of estrogen receptor gene polymorphisms with adolescent idiopathic scoliosis (AIS) risk.Previous studies have shown that genetic factors are important in pathogenesis scoliosis. Only 1 publication suggested XbaI site polymorphism was associated curve severity However, to our knowledge, relationship and individual susceptibility has not been studied.This included 202 patients AIS 174 healthy controls. Height, menarche status,...
Systemic exposure to nicotine induces glutamatergic synaptic plasticity on dopamine (DA) neurons in the ventral tegmental area (VTA), but mechanisms are largely unknown. Here, we report that single, systemic rats (0.17 mg/kg free base) increases ratio of DA neuronal currents mediated by AMPA relative NMDA receptors (AMPA/NMDA ratio) assessed 24 h later, based slice-patch recording. The AMPA/NMDA increase is evident within 1 and lasts for at least 72 after (and up 8 d repeated...
We report the imaging of cell-substrate adhesion a single cell with subcellular spatial resolution. Osmotic pressure was introduced to provide controllable mechanical stimulation attached substrate, and high-resolution surface plasmon resonance microscopy used map response cell, from which local determined. In addition high resolution, approach is noninvasive fast allows for continuous mapping interactions single-cell movements.
Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report endogenous IL-17 ablates neurogenesis in adult dentate gyrus (DG) hippocampus. Genetic deletion increased number adult-born neurons DG. Further, found altered network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability and...
The distribution of postsynaptic glutamate receptors has been shown to be regulated by proimmunocytokine tumor necrosis factor α (TNF-α) signaling. role TNF-α receptor subtypes in mediating expression, trafficking, and function still remains unclear. Here, we report that TNF (TNFR1 TNFR2) differentially modulate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPAR) clustering cultured cortical neurons. We find genetic deletion TNFR1 decreases surface expression synaptic localization...
Diverse nicotinic acetylcholine receptor (nAChR) subtypes containing different subunit combinations can be placed on nerve terminals or soma/dendrites in the ventral tegmental area (VTA). nAChR α6 message is abundant VTA, but α6*-nAChR cellular localization, function, pharmacology, and roles cholinergic modulation of dopaminergic (DA) neurons within VTA are not well understood. Here, we report evidence for α6β2*-nAChR expression GABA neuronal boutons terminating DA neurons. α-Conotoxin...
Studying electrical activities in cells, such as action potential and its propagation neurons, requires a sensitive non-invasive analytical tool that can image local signals with high spatial temporal resolutions. Here we report plasmonic-based electrochemical impedance imaging technique to study transient single cells. The is based on the conversion of signal into plasmonic signal, which imaged optically without labels. We demonstrate fast initiation within validate traditional patch clamp...