A5101648373- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Autophagy in Disease and Therapy
- Sphingolipid Metabolism and Signaling
- Sperm and Testicular Function
- Neuroscience and Neuropharmacology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Tryptophan and brain disorders
- Endoplasmic Reticulum Stress and Disease
- Inflammation biomarkers and pathways
- Immune cells in cancer
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Ovarian function and disorders
- Adenosine and Purinergic Signaling
- Mitochondrial Function and Pathology
- Biochemical and Structural Characterization
- Cancer-related molecular mechanisms research
- Selenium in Biological Systems
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Fibrosis and Remodeling
- Redox biology and oxidative stress
Nanjing Medical University
2016-2025
University of Missouri
2008-2024
Nanjing Maternity and Child Health Care Hospital
2016-2024
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2019
Chinese Academy of Medical Sciences Dermatology Hospital
2019
Drug Discovery Laboratory (Norway)
2017
Sun Yat-sen University
2015
Summary Microglia‐mediated neuroinflammation plays a dual role in various brain diseases due to distinct microglial phenotypes, including deleterious M1 and neuroprotective M2. There is growing evidence that the peroxisome proliferator‐activated receptor γ ( PPAR γ) agonist rosiglitazone prevents lipopolysaccharide LPS )‐induced activation. Here, we observed antagonizing promoted ‐stimulated changes polarization from M2 phenotype primary microglia. antagonist T0070907 increased expression of...
There is increasing interest in the association between depression and development of metabolic diseases. Rosiglitazone, a therapeutic drug used to treat type 2 diabetes mellitus, has shown neuroprotective effects patients with stroke Alzheimer's disease. The present study was performed evaluate possible roles rosiglitazone vivo (unpredictable chronic mild stress-induced depressive mouse model) vitro (corticosterone-induced cellular models. results showed that reversed behaviors mice, as...
It is generally recognized that the inflammatory reaction in glia one of important pathological factors brain ischemic injury. Our previous study has revealed opening ATP-sensitive potassium (K-ATP) channels could attenuate glial inflammation induced by stroke. However, detailed mechanisms are not well known.Primary cultured astrocytes separated from C57BL/6 mice were subjected to oxygen-glucose deprivation (OGD); cellular injuries determined via observing changes morphology and cell...
Abstract Mitochondria, acting as the energy metabolism factory, participate in many key biological processes, including maintenance of sperm viability. Mitochondria-related microRNA (miRNA), encoded by nuclear genome or mitochondrial genome, may play an important regulatory role control function. To investigate potential mitochondria-related miRNAs asthenozoospermia, we adopted a strategy consisting initial screening TaqMan Low Density Array (TLDA) and further validation with quantitative...
Abstract Paclitaxel is generally used to treat cancers in clinic as an inhibitor of cell division. However, the acquired resistance tumours limits its clinical efficacy. Therefore, aim this study was detect whether co‐treatment with lentinan enhanced anti‐cancer effects paclitaxel A549 cells. We found that combination and resulted a significantly stronger inhibition on proliferation than treatment alone. Co‐treatment apoptosis rate by inducing caspase‐3 activation. Furthermore, triggered...
Abstract Mitochondria-related microRNAs (miRNAs) have recently emerged as key regulators of cell metabolism and can modulate mitochondrial fusion division. In order to investigate the roles mitochondria-related miRNAs played in obesity, we conducted comprehensive molecular analysis vitro vivo . Based on high-fat-diet (HFD) induced obese mice, found that hepatic function was markedly altered. Subsequently, evaluated expression levels selected miR-141-3p up-regulated strikingly HFD mice. To...
Previous studies report that lipopolysaccharide (LPS)-preconditioned mesenchymal stem cells have enhanced trophic support and improved regenerative repair properties. Extracellular vesicles secreted by synovial (EVs) can reduce cartilage damage caused osteoarthritis (OA). show extracellular LPS-preconditioned (LPS-pre EVs) improve the response to treatment of This study sought explore effects LPS-pre EVs on chondrocyte proliferation, migration, apoptosis, as well protective effect mouse...
The mechanism of sphingosine-1-phosphate (S1P)-mediated phagocytosis remains unknown. Here, we found that S1P or FTY720 (an analog S1P) promoted microglial in stroke independent S1PRs. First, used computer simulation molecular docking to predict might be a ligand for triggering receptor expressed on myeloid cells 2 (TREM2). Next, microscale thermophoresis (MST), surface plasmon resonance (SPR) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were performed reveal was novel TREM2...
Sphingosine 1-phosphate (S1P) is involved in a variety of cellular responses including microglial activation and polarization. However, the impacts S1P on ischemia-induced polarization remain unclear. In present study, Sprague-Dawley rats were selected for middle cerebral artery occlusion (MCAO) establishment treated with analog FTY720 (0.5, 1, 2 mg/kg) 24 h. The oxygen-glucose deprivation (OGD)-induced examined primary cultured microglia. treatment could prevent brain injury neurological...
TEA domain (TEAD) transcription factors serve important functional roles during embryonic development and in striated muscle gene expression. Our previous work has implicated a role for TEAD-1 the fast-to-slow fiber-type transition response to mechanical overload. To investigate whether is modulator of slow expression vivo, we developed transgenic mice expressing hemagglutinin (HA)-tagged under control creatine kinase promoter. We show that muscle-restricted HA-TEAD-1 induced toward...
Abstract Oridonin, a natural diterpenoid compound extracted from Chinese herb, has been proved to exert anti‐oxidative stress effects in various disease models. The aim of the present study was investigate protective oridonin on oxidative stress‐induced endothelial injury ischaemic stroke. We found repaired blood‐brain barrier (BBB) integrity presented with upregulation tight junction proteins (TJ proteins) expression, inhibited infiltration periphery inflammatory cells and neuroinflammation...
Lipid metabolism dysfunction is widely involved in the pathological process of acute ischemic stroke (AIS). The coordination lipid between neurons and astrocytes great significance. However, full scope dynamic changes function key lipids during AIS remain unknown. Hence, identifying alterations characterizing their roles importance.
Oxidative stress-mediated astrocytic damage contributes to nerve injury and the development of depression, especially under stress conditions. Peroxisomes pexophagy are essential for balancing oxidative protein degradation products. Our previous findings suggest that peroxisome proliferators-activated receptor β/δ (PPARβ/δ) activation significantly alleviates depressive behaviors by preventing injury. However, underlying mechanisms remain unclear. In present study, we established treating...
BACKGROUND: Following ischemic white matter damage, microglia are responsible for phagocytosing and degrading cholesterol-rich myelin debris, storing them as lipid droplets. However, our understanding of how process this engulfed material remains limited. Our previous findings identified FTY720 a high-affinity ligand microglial TREM2 (triggering receptor expressed on myeloid cells 2). Therefore, we aimed to reveal the role targeting in regulating cholesterol metabolism during remyelination....
Abstract Fingolimod ( FTY 720) is used as an immunosuppressant for multiple sclerosis. Numerous studies indicated its neuroprotective effects in stroke. However, the mechanism remains to be elucidated. This study was intended investigate mechanisms of phosphorylated 720 pFTY 720), which principle active molecule regulating astrocyte‐mediated inflammatory responses induced by oxygen‐glucose deprivation OGD ). Results demonstrated that could protect astrocytes against ‐induced injury and...
Glioblastoma (GBM) is one of the most malignant and aggressive primary brain tumors. The incurability glioblastoma heavily influenced by glioma microenvironment. FTY720, a potent immunosuppressant, has been reported to exert anti-tumor effects in glioblastoma. However, impact FTY720 on microenvironment remains unclear.