A5110771609- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Erythrocyte Function and Pathophysiology
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Inflammation biomarkers and pathways
- PARP inhibition in cancer therapy
- RNA Research and Splicing
- Circular RNAs in diseases
- Machine Learning and ELM
- Fatty Acid Research and Health
- Face and Expression Recognition
- Plasma Applications and Diagnostics
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medicinal Plants and Bioactive Compounds
- Ferroptosis and cancer prognosis
- Trace Elements in Health
- Peroxisome Proliferator-Activated Receptors
- Hippo pathway signaling and YAP/TAZ
- Phagocytosis and Immune Regulation
- Sphingolipid Metabolism and Signaling
Chinese Academy of Fishery Sciences
2025
Ningxia Medical University
2024
Fujian Medical University
2017-2024
Jiangnan University
2024
Tongji University
2021-2023
Shanghai Tenth People's Hospital
2021
Nanjing Medical University
2021
Eastern Hepatobiliary Surgery Hospital
2019-2020
Second Military Medical University
2019-2020
Fudan University Shanghai Cancer Center
2019-2020
Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches, found mutationally activated strikingly increased intracellular cystine levels and glutathione biosynthesis. SLC7A11, cystine/glutamate antiporter conferring specificity for uptake, was overexpressed patients KRAS-mutant LUAD showed positive...
Abstract Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction. Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment. However, such strategies show limited efficacy due to drug resistance and other largely unknown underlying mechanisms. Here we report that cystine transporter SLC7A11 upregulated in lung stem-like cells (CSLC) can be activated stem transcriptional factor SOX2. Mutation of SOX2 binding site promoter reduced...
Abstract Tumor necrosis happens commonly in advanced solid tumors. We reported that necroptosis plays a major role tumor necrosis. Although several key regulators including receptor interacting protein kinase 1 (RIPK1) have been identified, the regulation of during development remains elusive. Here, we report Z-DNA-binding (ZBP1), not RIPK1, mediates preclinical cancer models. found ZBP1 expression is dramatically elevated necrotic Importantly, ZBP1, deletion blocks and inhibits metastasis....
Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain that occurs when blood supply is restored ischemic tissue and one of the leading causes adult disability mortality. Multiple pathological mechanisms are involved in progression CIRI, including neuronal oxidative stress mitochondrial dysfunction. Isoliquiritigenin (ISL) has been preliminarily reported have potential neuroprotective effects on rats subjected cerebral insult. However, protective ISL not elucidated. This...
The mechanism of sphingosine-1-phosphate (S1P)-mediated phagocytosis remains unknown. Here, we found that S1P or FTY720 (an analog S1P) promoted microglial in stroke independent S1PRs. First, used computer simulation molecular docking to predict might be a ligand for triggering receptor expressed on myeloid cells 2 (TREM2). Next, microscale thermophoresis (MST), surface plasmon resonance (SPR) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were performed reveal was novel TREM2...
The bromodomain and extra-terminal domain (BET) proteins are promising therapeutic targets to treat refractory solid tumors; however, inherent resistance remains a major challenge in the clinic. Recently, emerging role of oncoprotein B cell lymphoma 6 (BCL6) tumorigenesis stress response has been unveiled. Here, we demonstrate that BCL6 was upregulated upon BET inhibition KRAS-mutant cancers, including non–small-cell lung cancer (NSCLC). We further found BRD3, not BRD2 or BRD4, directly...
Abstract Necroptosis, a regulated form of necrosis, has emerged as novel therapeutic strategy that could enhance cancer immunotherapy. However, its role in tumorigenesis is still debated because recent studies have reported both anti- and pro-tumoral effects. Here, we aimed to systematically evaluate the associations between tumor necroptosis (mixed lineage kinase domain-like protein, MLKL; phosphorylated MLKL, pMLKL; receptor-interacting protein 1–receptor-interacting 3, RIPK1–RIPK3...
Head and neck cancer (HNC) is the seventh most prevalent globally, often characterized by chemo-resistance immunosuppression, which significantly hampers treatment efficacy. Cold atmospheric plasma (CAP) has recently emerged as a promising adjuvant oncotherapy with substantial potential advantages. In this study, Piezobrush® PZ2, handheld CAP unit based on piezoelectric direct discharge technology, was used to generate deliver non-thermal plasma. We aimed investigate effects of CAPPZ2...
MicroRNA (miRNA/miR), a type of non‑coding RNA molecule, is able to inhibit the expression target genes at multiple stagess. There are 800‑1,000 known miRNAs in human genome, which serve important roles cell proliferation, differentiation, apoptosis and migration. Previous studies have demonstrated that miR‑21 upregulated numerous types malignant tumor, participates occurrence development tumors via complex regulatory mechanisms. The present study aimed investigate association between...
Abstract Acute coronary syndrome caused by the rupture of atherosclerotic plaques is one primary causes cerebrovascular and cardiovascular events. Neovascularization within plaque closely associated with its stability. Long non‐coding RNA (lncRNA) serves a crucial role in regulating vascular endothelial cells (VECs) proliferation angiogenesis. In this study, we identified lncRNA HCG11, which highly expressed patients vulnerable compared stable plaque. Then, functional experiments showed that...
Background: This study employed Mendelian randomization (MR) analysis to confirm the causal effects of mental disorders on fibromyalgia.Methods: The summary data for exposures, mediator, and outcome were extracted from GWAS catalog project, IEU openGWAS Finn biobank database.Significantly associated independent single-nucleotide polymorphisms (SNPs) meeting criteria p < 5×10-8, r2 0.001, kb = 10,000 selected MR analysis.We used univariate multivariate (i) investigate relationship between...