A5100666441- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- Sphingolipid Metabolism and Signaling
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Knee injuries and reconstruction techniques
- Cell death mechanisms and regulation
- Bioactive Natural Diterpenoids Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Epigenetics and DNA Methylation
- Circadian rhythm and melatonin
- Macrophage Migration Inhibitory Factor
- Osteoarthritis Treatment and Mechanisms
- Dementia and Cognitive Impairment Research
- Natural product bioactivities and synthesis
Wuxi No.2 People's Hospital
2022
Nanjing Medical University
2018-2022
Astrocytes act as immune effector cells with the ability to produce a wide array of chemokines and cytokines in response various stimuli. Macrophage migration inhibitory factor (MIF) is inducibly expressed injured spinal cord contributing excessive inflammation that affects motor functional recovery. Unknown whether MIF can facilitate inflammatory responses through stimulating release from astrocytes following injury.Following establishment contusion injury rat model, correlation chemokine...
Previous studies report that lipopolysaccharide (LPS)-preconditioned mesenchymal stem cells have enhanced trophic support and improved regenerative repair properties. Extracellular vesicles secreted by synovial (EVs) can reduce cartilage damage caused osteoarthritis (OA). show extracellular LPS-preconditioned (LPS-pre EVs) improve the response to treatment of This study sought explore effects LPS-pre EVs on chondrocyte proliferation, migration, apoptosis, as well protective effect mouse...
Abstract Extracellular vesicles (EVs), as a novel intercellular communication carrier transferring cargo microRNAs (miRNAs), could play important roles in the brain remodeling process after ischemic stroke. However, detailed mechanisms involved EVs derived miRNAs-mediated cellular interactions remain unclear. Several studies indicated that microRNA-98 (miR-98) might participate pathogenesis of Here, we showed expression miR-98 penumbra field kept up on first day but dropped sharply 3rd...
The mechanism of sphingosine-1-phosphate (S1P)-mediated phagocytosis remains unknown. Here, we found that S1P or FTY720 (an analog S1P) promoted microglial in stroke independent S1PRs. First, used computer simulation molecular docking to predict might be a ligand for triggering receptor expressed on myeloid cells 2 (TREM2). Next, microscale thermophoresis (MST), surface plasmon resonance (SPR) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were performed reveal was novel TREM2...
Epigenetic clocks are based on age-associated changes in DNA methylation of CpG-sites, which can accurately measure chronological age different species.Recently, several studies have indicated that the difference between and epigenetic age, defined as acceleration, could reflect biological indicating functional decline diseases.In humans, an clock associated Alzheimer's disease (AD) pathology with acceleration age.In this study, we developed validated two mouse brain regionspecific from...
Abstract Oridonin, a natural diterpenoid compound extracted from Chinese herb, has been proved to exert anti‐oxidative stress effects in various disease models. The aim of the present study was investigate protective oridonin on oxidative stress‐induced endothelial injury ischaemic stroke. We found repaired blood‐brain barrier (BBB) integrity presented with upregulation tight junction proteins (TJ proteins) expression, inhibited infiltration periphery inflammatory cells and neuroinflammation...
Synaptic plasticity damages play a crucial role in the onset and development of depression, especially hippocampus, which is more susceptible to stress most frequently studied brain region depression. And, mitochondria have major function executing complex processes neurotransmission plasticity. We previously demonstrated that Iptakalim (Ipt), new ATP-sensitive potassium (K-ATP) channel opener, could improve depressive-like behavior mice. But underlying mechanisms are not well understood....
Abstract Although astrocytes undergo functional changes in response to brain injury and may be the driving force of subsequent neuronal death, underlying mechanisms remain incompletely elucidated. Here, we showed that extracellular vesicle (EV)-shuttled miRNA-382-5p serve as a biomarker for severity traumatic (TBI), circulating EV-miRNA-382-5p level was significantly increased both human patients TBI model mice. Mechanistically, astrocyte-derived EVs delivered shuttled mediate...
Abstract Background: Activation of TREM2 protects against brain injury in ischemic stroke via immunoregulation. However, the endogenous ligand remains unknown. Here, we tested hypothesis that S1P, an immunoregulator, functions as to promote microglial phagocytosis. Methods: SD rats, C57BL/6J mice and -/- were subjected transient middle cerebral artery occlusion, primary microglia oxygen-glucose deprivation. Phagocytosis was investigated immunofluorescence two-photon microscope. LC-MS/MS,...