A5056219207- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Mitochondrial Function and Pathology
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Brain Metastases and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Genetic Neurodegenerative Diseases
- Acute Ischemic Stroke Management
- Pain Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Attention Deficit Hyperactivity Disorder
- Forensic Toxicology and Drug Analysis
- Trauma and Emergency Care Studies
Air Force Medical University
2016-2025
Tang Du Hospital
2016-2024
State Council of the People's Republic of China
2022
China XD Group (China)
2016
Zero to Three
2008
Mitochondrial dysfunction and oxidative injury, which contribute to worsening of neurological deficits poor clinical outcomes, are hallmarks secondary brain injury after TBI. Adiponectin (APN), beyond its well-established regulatory effects on metabolism, is also essential for maintaining normal functions by binding APN receptors that ubiquitously expressed in the brain. Currently, significance APN/APN receptor (AdipoR) signaling pathway TBI specific mechanisms have not been conclusively...
Blood-brain barrier (BBB) injury critically exacerbates the poor prognosis of patients with subarachnoid hemorrhage (SAH). The massively increased matrix metalloproteinases 9 (MMP-9) plays a deleterious role in BBB. However, main source and mechanism MMP-9 production after SAH remain unclear. We reported that was mainly derived from reactive astrocytes SAH. Ndrg2 knockout inhibited expression attenuated BBB damage. Astrocytic decreased phosphorylation Smad2/3 transcription MMP-9. Notably,...
Various forms of neuronal death contribute to neurological injury after traumatic brain (TBI), leading irreversible deficits. Among these, ferroptosis is a form regulated cell characterized by the accumulation iron-dependent lipid hydroperoxides and induced incorporation polyunsaturated fatty acids (PUFAs) into cellular membranes. Adiponectin (APN), cytokine secreted adipocytes, have showed neuroprotective effects binding adiponectin receptors (AdipoRs), which are widely expressed in central...
Abstract Traumatic brain injury (TBI) is a risk factor for posttraumatic stress disorder (PTSD). Augmented fear defining characteristic of PTSD, and the amygdala considered main region to process fear. The mechanism by which involved in conditioning after TBI still unclear. Using single‐nucleus RNA sequencing (snRNA‐seq), transcriptional changes cells are investigated. In total, 72 328 nuclei obtained from sham groups. 7 cell types, analysis differentially expressed genes (DEGs) reveals...
Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain (TBI), which result in progressive pathophysiological exacerbation. Although the Fibronectin type III domain-containing 5 (FNDC5) was reported to repress by retaining mitochondrial biogenesis dynamics, its possible role TBI remain obscure. In present study, we observed that level of serum irisin (the cleavage product FNDC5) significantly correlated with neurological outcomes...
Abstract Objectives 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a metabolite of arachidonic catalysed by cytochrome P450 enzymes and plays an important role in cell death proliferation. We hypothesized that 20‐HETE synthesis inhibition may have protective effects traumatic brain injury (TBI) investigated possible underlying molecular mechanisms. Materials methods Neurologic deficits, lesion volume, reactive oxygen species (ROS) levels as assessed using immunofluorescence staining,...
Abstract Pivotal roles of extracellular vesicles (EVs) in the pathogenesis central nervous system (CNS) disorders including acute brain injury are increasingly acknowledged. Through analysis EVs packaged miRNAs plasma samples from patients with intracerebral hemorrhage (ICH), it is discovered that level miR‐143‐3p (EVs‐miR‐143‐3p) correlates closely perihematomal edema and neurological outcomes. Further study reveals that, upon ICH, EVs‐miR‐143‐3p robustly secreted by astrocytes can shuttle...
VGLUT1 and VGLUT2 have been reported to show complementary distributions in most brain regions assumed define distinct functional elements. In the present study, we first investigated expression of trigeminal sensory nuclear complex rat by dual-fluorescence situ hybridization. Although and/or mRNA signals were detected all nuclei, colocalization was found only principal nucleus (Vp). About 64% glutamatergic Vp neurons coexpressed VGLUT2, others expressed either or indicating that might be...
OBJECTIVE Spontaneous basal ganglia hemorrhage is a common type of intracerebral (ICH) with no definitive treatment. Minimally invasive endoscopic evacuation promising therapeutic approach for ICH. In this study the authors examined prognostic factors associated long-term functional dependence (modified Rankin Scale [mRS] score ≥ 4) in patients who had undergone hemorrhage. METHODS total, 222 consecutive underwent between July 2019 and April 2022 at four neurosurgical centers were enrolled...
Abstract Little is known about the significance of two types glutamatergic neurons (those expressing vesicular glutamate transporter VGLUT1 or VGLUT2) in control jaw movements. We thus examined origin and distribution axon terminals with VGLUT2 immunoreactivity within trigeminal motor nucleus (Vm) rat. The Vm was divided into dorsolateral division (Vm.dl; jaw‐closing motoneuron pool) ventromedial (Vm.vm; jaw‐opening pool). VGLUT1‐immunopositive were seen Vm.dl only, whereas...
Symptomatic intracranial hemorrhage (ICH) may lead to permanent neurological disability of patients and has impeded the extensive clinical application deep brain stimulation (DBS). The present study was conducted discuss incidence, prevention, treatment symptomatic ICH after DBS surgery.From January 2009 December 2014, 396 underwent with a total 691 implanted leads. In all, 10 had ICH. We analyzed these cases' characteristics, including comorbid diagnoses coagulation profile. described onset...
Background and Purpose: As a rare lesion secondary to brain trauma, traumatic intracranial aneurysms (TICAs) lead high mortality morbidity, multiple treatment modalities have been applied for TICAs. All patients diagnosed with TICAs in our institution from 2010 2020 were included the report, their clinical features, treatment, outcomes are described detail. The purpose of this study is illustrate characteristic different therapeutic methods TICAs, focus on endovascular treatment. Methods: A...
Death-associated protein kinase 1 (DAPK1), a Ca 2+ /calmodulin-dependent serine/threonine-protein kinase, promotes neurons apoptosis in ischemic stroke and Alzheimer’s disease (AD). We hypothesized that knockdown DAPK1 may play protective role traumatic brain injury (TBI) explore underlying molecular mechanisms. ELISA, Western blotting, immunofluorescence, dual-luciferase assay, Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR) were used to determine the mechanism for of...
Rationale: Neuroadaptations in the medial prefrontal cortex (mPFC) and Nucleus Accumbens (NAc) play a role disruption of control-reward circuits opioid addiction.Small Conductance Calcium-Activated Potassium (SK) channels mPFC have been implicated neuronal excitability changes during morphine withdrawal.However, mechanism that modulates SK withdrawal is still unknown.Methods: Rats were exposed for one week to daily injections (10 mg•kg -1 s.c.) followed by conditional place preference (CPP)...
Glioblastoma (GBM) is the most common primary malignant intracranial tumor and median age at diagnosis 65 years. However, elderly patients are usually excluded from clinical studies considered as an independent negative prognostic factor for with GBM. Therefore, best treatment method GBM in has remained controversial. Elderly (≥ 60 years old) treated between January 2015 December 2019 were enrolled this study. Medical records reviewed retrospectively, clinicopathological characteristics,...