About
Contact & Profiles
A5036280947
Research Areas
- Mechanisms of cancer metastasis
- Connective Tissue Growth Factor Research
- Peptidase Inhibition and Analysis
Air Force Medical University
2022
Blood-brain barrier (BBB) injury critically exacerbates the poor prognosis of patients with subarachnoid hemorrhage (SAH). The massively increased matrix metalloproteinases 9 (MMP-9) plays a deleterious role in BBB. However, main source and mechanism MMP-9 production after SAH remain unclear. We reported that was mainly derived from reactive astrocytes SAH. Ndrg2 knockout inhibited expression attenuated BBB damage. Astrocytic decreased phosphorylation Smad2/3 transcription MMP-9. Notably,...
10.1126/sciadv.abq2423
article
EN
cc-by-nc
Science Advances
2022-09-30
Coming Soon ...