Gold nanoparticle-based miR155 antagonist macrophage delivery restores the cardiac function in ovariectomized diabetic mouse model Chengming Jia,1,2,* Hui Chen,3,* Mengying Wei,2,* Xiangjie Chen,4 Yajun Zhang,5 Liang Cao,1 Ping Yuan,1 Fangyuan Wang,1 Guodong Yang,2 Jing Ma1 1Department of Chinese Medicine, Xijing Hospital, The Fourth Military Medical University, Xi’an, China; 2Department Biochemistry and Molecular Biology, 3Department Plastic Surgery, Tangdu 4Department Mathematics,...

To date, numerous methods have been successfully developed to functionalize N-heteroaryl C–H bonds. In contrast, dearomative tandem functionalization of N-heteroarenes is still a subject be explored. Reported herein an example on reductive dearomatization-induced by ruthenium catalysis, which offers general method for diastereoselective construction fused heterocycles featuring cyclic syn-N, O-acetal motif from N-heteroarenes, phenols, and paraformaldehyde. Mechanistic study reveals that the...

Abstract Continuous cropping has a negative effect on soybean yield. In this study, positioning experiment was conducted starting in 2015, with three treatments: maize–soybean rotation (SMR), 2-year maize, (SC2), and 8-year continuous (SC8). We determined yields (2015–2022) analyzed soil microbial communities, functions, metabolites composition the 0–20 cm tillage layer using metagenomics technology GC–MS during flowering 2022. Results indicated that (SC8) significantly reduced yield...

In order to investigate the role of melatonin in drought tolerance, we examined pigments, gas exchange, osmolytes, and reactive oxygen radical metabolism soybean plants. Drought declined photosynthetic pigments caused irreversible reduction net photosynthesis, which was followed by stomatal limitation for 5 10 d nonstomatal 15 d. Soluble sugar, soluble proteins, proline concentrations were higher drought-stressed seedlings compared with control. The contents superoxide anion, hydrogen...

To date, although tremendous advances have been made in N-heteroaryl C–H functionalization, there remain significant unmet challenges the deconstruction of extensively applied but poorly reactive N-heteroaromatics to useful frameworks. Here, by a strategy merging hydrogen transfer and selective coupling, we present ruthenium-catalyzed functionalized arylamines with 2-aminoaryl methanols. The reaction is achieved via sequential functionalization β α sites initially formed N-heteroarenium...

Understanding the relationship between exogenous melatonin and water deficit stress is crucial for alleviating effects of at germination stage soybean ( Glycine max (L . ) Merrill in agriculture. This study investigated on antioxidant properties cell ultrastructure under induced by polyethylene glycol (PEG) 6000. The drought-sensitive variety Suinong 26 was used as material to different concentrations (0, 300, 500 μmol·L -1 soaking seeds drought (PEG-6000: 3% 6%). results showed that rate...

Soybean whey and soybean hydrolyzate can be used for the biotechnological production of high-value products. Herein, we isolate (SW)-and (SH)-derived bacterial cellulose (BC, produced by kombucha) characterize it a range instrumental techniques to reveal differences in micromorphology, crystallinity, themal behavior. Studies have shown that amounts wet state BC from HS, SW SH was 181 g/L, 47 g/L 83 respectively. The analysis BC, included SEM, AFM, FT-IR, XRD TGA. It is FT-IR spectra similar...

To investigate the application of transesophageal echocar-diography assessment for mitral valve in patients with atrial septal defects undergoing repair surgery. Thirty-two adult defect underwent thoracoscopic surgery at First Affiliated Hospital Military Medical University PLA Air Force from March to September 2022 were collected (study group). The two-dimensional and real-time three-dimensional ultrasonography performed after anesthesia. parameters structure late diastolic systolic stages...

To compare the efficacy of transcatheter tricuspid valve replacement (TTVR) using Lux-Valve and Plus in patients with severe regurgitation. A total 28 consecutive regurgitation who underwent TTVR (n=14) or First Affiliated Hospital Air Force Medical University from August 2019 to November 2023 were enrolled. Transthoracic echocardiography was performed all before 6 months after TTVR. The ultrasound indexes compared between groups. Intraoperative bleeding significantly reduced, length...

Given the global climate change, soybean production is highly susceptible to low temperature. Although tryptophan, synthesis precursors of melatonin and auxin, exhibited a positive effect in regulating plant growth, it still unclear whether tryptophan could improve tolerance temperature stress through endogenous synthesis. Therefore, on resistance two varieties seedlings (4°C) was evaluated, main regulation pathway verified with inhibitors. The results revealed that significantly inhibited...

There is a growing need to enhance the productivity of soybean (Glycine max L.) under severe drought conditions in order improve global food security status. Melatonin, ubiquitous hormone, could alleviate stress various plants. Earlier, we demonstrated that exogenous melatonin treatment tolerance drought-treated soybean. However, underlying mechanisms by which this hormone exerts resistance still unclear. The present study used transcriptomic and metabolomic techniques determine some...

Despite the widespread applications of 2-(hetero)aryl N-heteroarenes in numerous fields science and technology, universal access to such compounds is hampered due lack a general method for their synthesis. Herein, by H2O-mediated H2-evolution cross-coupling strategy, we report an iridium(III)-catalyzed facile direct α-arylation with both aryl heteroaryl boronic acids, proceeding broad substrate scope excellent functional compatibility, oxidant reductant-free conditions, operational...

Melatonin (MT) is a key plant growth regulator. To investigate its effect at different stages on the yield of soybean under nitrogen deficiency, 100 μM MT was applied to supplemented with zero (0N), low (LN), and control (CK) levels, during vegetative (V3) filling (R5) stages. This study revealed that application mainly enhanced fixation plants by increasing root nodule number provided more substrates for glutamine synthetase (GS) 0N supply. However, LN supply, ammonium assimilated through...

Gastric cancer (GC) is one of the most common and fatal types cancers worldwide specific mechanism has not been completely elucidated. microRNA (miR)‑3664‑5P rarely studied aim present study was to assess an association between miR‑3664‑5P GC. Differences in expression 100 GC (0.1846±0.08276) paired normal tissues (0.4382±0.1595) were detected using reverse transcription‑quantitative polymerase chain reaction assays (P<0.001). 5‑Ethynyl‑2‑deoxyuridine, Cell Counting Kit‑8, transwell flow...

By employing reusable nanocobalt oxides as the catalysts, a site-specific oxidative C-H chalcogenation of (hetero)aryl-fused cyclic amines with various thiols and diselenides is presented for first time. The reaction proceeds selectively at sites (hetero)aryl rings para to N atom, enables access wide array chalcogenyl N-heteroarenes. merits transformation involve high step- atom-efficiency, excellent substrate functional compatibility, operational simplicity, use naturally abundant Co/O2...

Herein, we present a ruthenium-catalyzed new hydrogen evolution ortho-aminoalkylation of phenolic derivatives with cyclic amines as the coupling agents. The developed cross-coupling reaction offers practical platform for direct access to variety functionalized phenols features good substrate and functional group compatibility, readily available catalyst system feedstocks, no need additional sacrificial oxidants, high atom efficiency.

Selective linkage of renewable alcohols and ammonia into functional products would not only eliminate the prepreparation steps to generate active amino agents but also help in conservation our finite fossil carbon resources contribute reduction CO

To investigate the function of melatonin (MT) on nitrogen uptake and metabolism in soybean, six groups treatments, with without 100 μM were conducted at low, normal, high levels (1.5, 7.5, 15 mM, respectively). The related indexes antioxidant system seedlings measured analysed. Results indicated that MT could enhance level by upregulating coding genes enzymes to increasing total content, especially under low levels. Under conditions, addition not only accelerated ammonium assimilation...