A5101565869- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Breast Cancer Treatment Studies
- Aortic Disease and Treatment Approaches
- Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Infective Endocarditis Diagnosis and Management
- HER2/EGFR in Cancer Research
- Esophageal Cancer Research and Treatment
- Advanced Breast Cancer Therapies
- Multiple and Secondary Primary Cancers
- Surfactants and Colloidal Systems
- Histone Deacetylase Inhibitors Research
- Toxoplasma gondii Research Studies
- Chromatin Remodeling and Cancer
- Sarcoma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Protein Degradation and Inhibitors
- Sulfur Compounds in Biology
- Cancer Treatment and Pharmacology
- Urinary and Genital Oncology Studies
- Lung Cancer Treatments and Mutations
Air Force Medical University
2015-2025
Xijing Hospital
2015-2025
Second Military Medical University
2023
Southeast University
2022-2023
Zigong First People's Hospital
2023
Changhai Hospital
2023
Nanchang University
2022
State Key Laboratory of Digital Medical Engineering
2022
Second Affiliated Hospital of Nanchang University
2022
Hengshui University
2021
Transcatheter mitral valve replacement (TMVR) may emerge as a surgical alternative for high-risk patients with severe annular calcification (MAC), yet several questions remain to be addressed. We present the case of 67-year-old female patient MAC (MAC score = 8) and stenosis (effective orifice area 121.3 mm2). To avoid conventional surgery, we opted perform TMVR using novel Mi-thos system via transapical approach. utilized patient-specific three-dimensional printed model derived by...
To compare the efficacy of transcatheter tricuspid valve replacement (TTVR) using Lux-Valve and Plus in patients with severe regurgitation. A total 28 consecutive regurgitation who underwent TTVR (n=14) or First Affiliated Hospital Air Force Medical University from August 2019 to November 2023 were enrolled. Transthoracic echocardiography was performed all before 6 months after TTVR. The ultrasound indexes compared between groups. Intraoperative bleeding significantly reduced, length...
Background: The objective of this study was to provide an overview the clinical outcomes associated with single-port endoscopic nipple-sparing mastectomy total prepectoral breast implant reconstruction. Methods: From April 2021 2024, patients undergoing nipple/skin-sparing pre-pectoral reconstruction were selected evaluate efficacy and safety method collect information on patient-reported outcomes. Results: A 218 enrolled in study, which 207 completed follow-up, yielding a follow-up rate...
Neoadjuvant chemotherapy (NAC) has become the main treatment option for breast cancer. Its adverse drug reactions (ADRs) make NAC painful both physiologically and psychologically. The factor pathological complete remission (pCR) describes how well a series of six or more chemotherapeutic treatments works on patient. This study investigated possibility predicting pCR using only nodal sizes first three treatments. A best feature combination each cancer subtype was screened from real sizes`...
Therapeutic cancer vaccines offer the greatest advantage of enhancing antigen-specific immunity against tumors, particularly for immunogenic such as melanoma. However, clinical responses remain unsatisfactory, primarily due to inadequate T cell priming and development acquired immune tolerance. A major obstacle lies in inefficient uptake antigen by peripheral dendritic cells (DCs) their migration lymph nodes presentation. In this context, magnetic delivery antigen-loaded liposomes (Ag-MLs)...
GALNT14 is a member of N-acetylgalactosaminyltransferase enzyme family and mediates breast cancer cell development. Here, we find that regulates multidrug resistance (MDR) in cancer. The expression associated with MDR Higher level facilitates MCF-7 cells to resist Adriamycin, whereas knockdown sensitizes Adriamycin. Moreover, the associates P-gp, efflux pump localized on membrane, which could be underlying mechanism how induces MDR. In-depth analysis shows stability P-gp. Finally, higher...
This study aimed to evaluate the safety and feasibility of total endovascular repair aortic arch using a novel designed stent-graft system (Yanger system; Lifetech Scientific, Shenzhen, China) in vitro canine model.The Yanger is composed main stent-graft, branched delivery system. In an simulation test bench, was tested, success rate releasing, anchoring, positioning recorded analyzed. Meanwhile, vivo implantation carried out 16 healthy adult crossbreed dogs. The these stent-grafts evaluated...
Background: High mobility group box 2 (HMGB2) is abnormally expressed in human cancers and participated multiple biological behaviors, such as proliferation, invasion prognosis.However, its role hepatocellular carcinoma (HCC) largely unknown. Methods: In clinical sample analysis, 62 HCC patients were enrolled this study.The expression of HMGB2 was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) immunohistochemical method, prognosis data Kaplan-Meier analysis.In...
Poly (ADP-ribose) polymerase 1 (PARP1) is a typical representative of the PARP enzyme family and mainly related to DNA repair, gene transcription regulation, inflammation, oxidative stress. Studies have found that PARP1 involved in pathophysiological processes variety cardiovascular diseases. Chaperone-mediated autophagy (CMA) molecular regulation various diseases, including plays critical role maintaining intracellular metabolism balance. However, link between CMA cardiomyocytes remains...
Massive open online course (MOOC) exposes the challenge and subversion to traditional mode of education, its way sharing information knowledge brings a new revelation integrating resources in colleges universities. This paper presents an integration based on mixed xMOOC cMOOC which is compatible dissemination social academy. The purpose displaying curriculum system university accelerate pace integrate share resources, promote coordination innovation knowledge, propel professional interaction...
Surveys of Toxoplasma gondii infection in animals have been reported Yunnan province, southwestern China. However, limited information is available regarding the epidemiology T. among persons participated health screening Yunnan. From January 2014 to December 2016, a large-scale and cross-sectional serological survey was conducted reveal seroprevalence three major hospitals. A total 64,533 serum samples were collected anti-T. antibodies examined by commercially enzyme-linked immunosorbent...
Abstract Tumors with high mortality rates are still a major threat to human survival and health worldwide. In recent years, cancer immunotherapy has made rapid clinical progress in eliminating cancers by activating the host’s own immune system. Particularly, use of physiological bioactive gas molecules such as nitric oxide, carbon monoxide hydrogen sulfide have been developed novel immunotherapeutic strategies. this review, we summarized current strategies for antitumor via molecules,...
To investigate the effectiveness of endoscopic radical mastectomy for breast cancer combined with total pectoral muscle reconstruction implants.
Abstract Background: The heterogenetic nature of colorectal cancer (CRC) constitutes a major challenge for drug development. Simultaneous targeting multiple molecules by combination therapy provides promising strategy, but it requires identification more potentially useful targeted agents. Palbociclib, selective CDK4/6 inhibitor approved the treatment HR/ER-positive and HER2-negative breast cancer, exhibited anti-cancer versatility in several types cancer. In this study, we evaluated its...
Hsa-miR-599 was identified as a tumor suppressor against cancer. This study aimed to explore possible mechanisms of antitumor effect hsa-miR-599 breast Tissue specimens were collected from 106 cancer cases, and cell line MCF-7 cultured for in vitro experiments. The expression pattern measured via quantitative real-time polymerase chain reaction. Lipofectamine® 2000 reagent used transfection. Cell viability, motility apoptosis detected using MTT assay, transwell flow cytometer, respectively....
While modified radical mastectomy with level I and II axillary lymph node clearance is a typical operating method in breast surgery, III necessary some cases such as those involving apical nodes.Level dissection can provide accurate postoperative staging essential guidance for adjuvant therapy.Although it often difficult to expose the subclavian region dissect nodes, this case, author split pectoralis major muscle 2 cm inferior collarbone performed skeletonized complete dissection.The cut...
Vaccine Delivery In article 2301232, Jingyi Sheng, Fang Yang, Ning Gu, and co-workers introduce a magnetic-responsive cancer vaccine, employing antigen-loaded magnetic liposomes (Ag-MLs), for active lymph node targeting. These liposomes, containing mouse melanoma lysate, iron oxide nanoparticles, CpG adjuvant, display enhanced accumulation in nodes when magnetically guided demonstrate significant enhancement anti-tumor immunity model. This approach provides potential new avenues developing...