A5043990892- Metal and Thin Film Mechanics
- Pancreatitis Pathology and Treatment
- Diamond and Carbon-based Materials Research
- Boron and Carbon Nanomaterials Research
- Pancreatic and Hepatic Oncology Research
- Mitochondrial Function and Pathology
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Phagocytosis and Immune Regulation
- Axon Guidance and Neuronal Signaling
- Genetics and Neurodevelopmental Disorders
- MXene and MAX Phase Materials
- Genetic and Kidney Cyst Diseases
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Signaling Pathways in Disease
- Nuclear Receptors and Signaling
- Epigenetics and DNA Methylation
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Hedgehog Signaling Pathway Studies
- Carbon Nanotubes in Composites
- Neuroscience and Neuropharmacology Research
- Gastric Cancer Management and Outcomes
Shanghai First People's Hospital
2014-2025
Shanghai Jiao Tong University
2012-2025
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
Precise (India)
2023
Nanjing Medical University
2023
Chinese Academy of Sciences
2023
Key Laboratory of Guangdong Province
2023
Guangzhou University
2023
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2023
Background and Aims GLI1, as an indispensable transcriptional factor of Hedgehog signaling pathway, plays important role in the development pancreatic cancer (PC). DNA methyltransferases (DNMTs) mediate methylation quantity tumor-related genes. Our study aimed to explore relationship between GLI1 DNMTs. Methods Expressions DNMTs were detected tumor adjacent normal tissues PC patients by immunohistochemistry (IHC). PANC-1 cells treated cyclopamine GLI1-siRNA, while BxPC-3 transfected with...
Liver metastasis (LM) poses a significant challenge in cancer treatment, with limited available therapeutic options and poor prognosis. Understanding the dynamics of tumor microenvironment (TME) immune interactions is crucial for developing effective treatments. We find that WNT11 promoted CD8+ T-cell exclusion suppression, which was correlated prognosis LM. Mechanistically, WNT11-overexpressing cells directly reduce recruitment activity by decreasing CXCL10 CCL4 expression through...
Copper, an indispensable trace element for the human body, serves not only as a crucial auxiliary factor in redox reactions within organism but also significant constituent of numerous key metabolic enzymes.The COMMD family plays vital role regulating copper at both cellular and systemic levels, particularly realm tumor research, area notably deficient gastric cancer investigations.With advancement precision medical techniques, individualized precise screening treatment have become paramount...
Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes Kai Li,1,* Yongxing Zhang,2,* Mengting Chen,1 Yangyang Hu,1 Weiliang Jiang,1 Li Zhou,1 Sisi Li,1 Min Xu,1 Qinghua Zhao,2 Rong Wan1 1Department Gastroenterology, Shanghai First People’s Hospital, School Medicine, Jiao Tong University, Shanghai, Republic China; 2Department Orthopaedics, China *These authors contributed equally to this work Abstract: To improve the doxorubicin (DOX) and provide novel...
Abstract Background To evaluate the long-term efficacy of transoral incisionless fundoplication (TIF) with Medigus Ultrasonic Surgical Endostapler (MUSE) for gastroesophageal reflux disease (GERD). Methods A total 16 patients proton pump inhibitor-dependent had undergone TIF by MUSE in Shanghai General Hospital （Shanghai, China）from March 2017 to December 2018. Patients were followed up at 6 months, and GERD-health-related quality life (GERD-HRQL) questionnaire score, GERD (GERD-Q)...
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disorder with high mortality. Multiple clinical diseases can induce PAH, but the underlying molecular mechanisms shared in PAHs associated different remain unclear. The aim of this study to explore key candidate genes and pathways PAH congenital heart disease (CHD-PAH), connective tissue (CTD-PAH), idiopathic (IPAH). We performed differential expression analysis based on public microarray dataset GSE113439 identified 1,442...
The ultralong strontium- (Sr-) substituted hydroxyapatite (SrHAp) whiskers were successfully prepared using acetamide as homogeneous precipitation reagent. effect of the Sr substitution amount on lattice constants and proliferation human osteoblast cells (MG-63) was further investigated. results showed that SrHAp with diameter 0.2–12 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>μ</mml:mi></mml:mrow></mml:math>m length up to 200...
Abnormal metabolism is the hallmark of hepatocellular carcinoma. Targeting energy has become major focus cancer therapy. The natural product, sanguinarine, displays remarkable anti-tumor properties by disturbing homeostasis; however, underlying mechanism not yet been elucidated.
Poly (ADP-ribose) polymerase 1 (PARP1) is a typical representative of the PARP enzyme family and mainly related to DNA repair, gene transcription regulation, inflammation, oxidative stress. Studies have found that PARP1 involved in pathophysiological processes variety cardiovascular diseases. Chaperone-mediated autophagy (CMA) molecular regulation various diseases, including plays critical role maintaining intracellular metabolism balance. However, link between CMA cardiomyocytes remains...
Autophagy plays a deleterious role in ischemic myocardial injury. The deacetylase SIRT1 is well-established regulator of autophagy that can be modified by the ubiquitin-like protein SUMO1. Our previous work demonstrated another protein, FAT10, exerts cardioprotective effects against ischemia stabilizing caveolin-3 protein; however, FAT10 on through are unclear. Here, we constructed Fat10-knockout rat model to evaluate autophagy. In vivo and vitro assays confirmed suppressed protect heart...
Ternary Zr-Nb-N nanocomposite coatings were synthesized on Si(100) substrates by Multi-target Magnetron Co-sputtering. The structure and chemical composition binding energy of characterized X-ray diffractometry (XRD) Energy-dispersive spectroscopy (EDS) photoelectron (XPS). results measurements Nano Indenter indicated that the maximum hardness was up to 36 GPa elastic modulus close 425 at 30 W Zr power 120 NbN power. hardest coating also showed modest residual stress. These appeared be a...