Hypertriglyceridemia (HTG) aggravates the course of acute pancreatitis (AP). Intestinal barrier dysfunction is implicated in pathogenesis AP during which dysbiosis intestinal microbiota contributes to barrier. However, few studies focus on changes intestine HTG-related necrotizing (ANP). Here, we investigated and Paneth cell antimicrobial peptides (AMPs) ANP (HANP) rats. Rats fed a high-fat diet induce HTG was induced by retrograde injection 3.5% sodium taurocholate into biliopancreatic...

Abstract SBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis tumour cells. However, underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three cell lines were treated with CCK‐8 assessed cytotoxicity. Transcriptome was performed on Illumina platform verified qPCR. Western blot evaluated protein levels. Malondialdehyde (MDA), total superoxide dismutase (T‐SOD), Fe, glutathione (GSH) oxidized (GSSG)...

Abstract Junctional adhesion molecule-C (JAM-C) plays a key role in the promotion of reverse transendothelial migration (rTEM) neutrophils, which contributes to dissemination systemic inflammation and secondary organ damage. During acute pancreatitis (AP), inflammatory responses lead distant damage typically result lung injury (ALI). Here, we investigated rTEM neutrophils AP-associated ALI molecular mechanisms by JAM-C regulates neutrophil this disorder. In study, were identified peripheral...

Aim : To analyze the features and treatment of hypertriglyceridemia‐induced acute pancreatitis (HTGP) during pregnancy. Methods A retrospective study 21 pregnant women diagnosed with (AP) was performed. Patients were divided into biliary (ABP), HTGP, idiopathic groups according to etiology. Results 95% patients in third trimester gestation. The percentage HTGP higher than that ABP (48% vs.14%). severe (SAP) group (40.0% vs.0%). Ranson scores for moderately (MSAP) SAP significantly different...

An increase of Escherichia-Shigella was previously reported in acute necrotizing pancreatitis (ANP). We investigated whether Escherichia coli MG1655, an commensal organism, increased intestinal injury and aggravated ANP rats. induced by retrograde injection 3.5% sodium taurocholate into the biliopancreatic duct. Using gut microbiota-depleted rats, we demonstrated that microbiota involved pancreatic barrier dysfunction ANP. 16S rRNA gene sequencing quantitative PCR, found dysbiosis a...

Aim . To investigate the epidemiology, etiology, and severity of acute pancreatitis (AP) in urban suburban areas Shanghai 2011 2016. Methods A retrospective study patients admitted to General Hospital (urban campuses) with AP 2016 was undertaken. Patients were divided into biliary (ABP), hypertriglyceridemic (HTGP), alcoholic pancreatitis, other causes according etiology. Severity mild (MAP), moderately severe (MSAP), (SAP). Results area increased more rapidly than those area. The mean onset...

In recent years, the cure rate of acute pancreatitis (AP) has increased gradually, but morbidity recurrent (RAP) not decreased. Patients with RAP have a poor quality life and are more likely to develop into chronic pancreatitis. To investigate risk factors after first attack is very necessary.Patients episode AP admitted Shanghai General Hospital, Jiao Tong University School Medicine from January 2018 May 2021 were included in this retrospective study, follow-up was 3-45 months discharge....

Emerging evidence indicates that resistin and fascin-1 may possess a causal role in the development of several types cancers. However, clinical significance expression colorectal cancer (CRC) tissues is unclear, there are no reports any correlation between fascin-1. Our analyses explored CRC tissue analyzed prognostic observed positive The rate strongly (27.5%) was significantly higher than normal (5.2%). Strongly related to multiple poor factors CRC, including depth tumor invasion, lymph...

We previously reported that acute necrotizing pancreatitis (ANP) after normal or high-fat diet is associated with a decreased number of Paneth cells in ileal crypts. Here, we ablated rat model ANP and to investigate the effects on disease symptoms. Adult male Sprague-Dawley rats received standard chow for 2 weeks, which they were treated dithizone deplete cells. Six hours later, was established by retrograde injection sodium taurocholate into biliopancreatic duct. Rats sacrificed at 6, 12,...

Rhubarb is the peeled and dried root of Rheum palmatum L., tanguticum Maxim. ex Balf. or officinale Baill. Free total rhubarb anthraquinones (FTRAs) isolated extracted from display beneficial effects anti-inflammation immunological modulation. The timing immune regulation a major problem in immunotherapy for severe acute pancreatitis (SAP). several studies reported that FTRAs could reduce systemic inflammatory responses by inhibiting early overactivity gut rats with SAP. But, optimal...

Acute pancreatitis is initiated within pancreatic exocrine cells and sustained by dysregulated systemic inflammatory responses mediated neutrophils. Store-operated Ca2+ entry (SOCE) through ORAI1 channels in acinar triggers acute pancreatitis, inhibitors ameliorate experimental but the role of pancreatitis-associated lung injury has not been determined. Here, we showed mice with pancreas-specific deletion Orai1 (Orai1ΔPdx1, ∼70% reduction expression Orai1) are protected against tissue damage...

The present work aimed to investigate the role of Paneth cells in small intestinal injury during acute necrotizing pancreatitis (ANP) using rat models established by injection dithizone, a metal chelator zinc with ability selectively ablate cells. Sprague‑Dawley rats were randomly divided into four groups: Sham‑operated group, ANP group (3.5% sodium taurocholate solution, 1 ml/kg body weight), dithizone (100 mg/kg weight) and + (sodium solution was administered 6 h after injection). Each...

Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes peripheral blood M1 and M2 monocytes HTGP patients. A total 90 subjects were enrolled, among which 16 diagnosed with HTGP, 34 biliary (ABP), 20 hypertriglyceridemia (HTG), healthy controls (HC). Peripheral CD14+CD86+ CD14+CD206+...

Pancreatic ductal adenocarcinoma has a poor prognosis due to late diagnosis and lack of effective therapeutic options. Thus, it is important better understand its molecular mechanisms develop more treatments for the disease. The ternary complex factor Net, which exerts strong inhibitory function on transcription proto-oncogene gene c-fos by forming complexes with second factor, been suspected being involved in pancreatic cancer other tumors biology. In this study, we found that majority...

Summary A 34–year‐old woman patient was found to have a chronic hereditary haemolytic anaemia. No abnormal haemoglobin band detected by conventional electrophoresis, but slow β chain could be separated on urea‐carboxymethyl cellulose chromatography. Investigations of the patient's revealed an unstable component. Analyses chemical structure, including isolation and TPCK trypsin digestion globin chain, HPL chromatography, amino acid composition as well sequence determination peptide, indicated...

Objective: To investigate the association between serum gamma-glutamyl transferase (GGT) levels and uric acid in middle-aged elderly Chinese females. Methods: A cross-sectional population survey was performed Luzhou, China (2014). Questionnaires, physical examinations biochemical tests were conducted. Finally, we included 2486 females who > 40 years old as participants. Multiple linear regression analysis used to estimate of other variables. Serum GGT divided into four groups using 25th,...

Objective To investigate the potential therapeutic role of porous SiO 2 ‐coated ultrasmall selenium particles nanospheres (Se@SiO nanospheres) pretreatment in acute pancreatitis (AP) and to related mechanism. Methods C57BL/6 mice were randomized normal control (CON) group, AP (induced by cerulein injection) (CAE) pretreated with Se@SiO nanocomposites at 1 mg/kg (CAE + or ) groups, respectively. Serum levels amylase lipase, inflammatory cytokines (interleukin [IL]‐6, IL‐1β tumor necrosis...