Zehua Huang

ORCID: 0000-0003-3120-9942
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About
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Research Areas
  • Food composition and properties
  • Pancreatitis Pathology and Treatment
  • Pancreatic and Hepatic Oncology Research
  • Polysaccharides Composition and Applications
  • Microbial Metabolites in Food Biotechnology
  • Polysaccharides and Plant Cell Walls
  • Food Industry and Aquatic Biology
  • Liver Disease Diagnosis and Treatment
  • Meat and Animal Product Quality
  • Dye analysis and toxicity
  • Gut microbiota and health
  • Diet, Metabolism, and Disease
  • Proteins in Food Systems
  • Gastrointestinal disorders and treatments
  • Vascular Anomalies and Treatments
  • Medicinal Plants and Bioactive Compounds
  • Adipose Tissue and Metabolism
  • Biological Stains and Phytochemicals
  • Postharvest Quality and Shelf Life Management
  • Inflammation biomarkers and pathways
  • Food Waste Reduction and Sustainability
  • Inflammasome and immune disorders
  • Enzyme-mediated dye degradation
  • Chromatography in Natural Products
  • Water Treatment and Disinfection

Hunan Normal University
2022-2024

Xuzhou Medical College
2023-2024

Changsha Normal University
2024

Henan University of Technology
2019-2023

Shanghai Jiao Tong University
2016-2023

Shanghai First People's Hospital
2019-2023

Magyar Agrár- és Élettudományi Egyetem
2023

National Engineering Research Center for Wheat
2023

Affiliated Hospital of Youjiang Medical University for Nationalities
2022

Second Affiliated Hospital of Nanjing Medical University
2022

Toll-like receptor 4 (TLR4) has been identified as a potentially promising therapeutic target in acute pancreatitis (AP). However, the role of intestinal TLR4 AP and AP-associated gut injury remains unclear. This study aimed to explore relationship between microbiota during AP. A mouse model was establish by intraperitoneal injection L-arginine. Pancreatic barrier function were evaluated wild-type epithelial knockout (TLR4ΔIEC) mice. Gut analyzed 16S rRNA sequencing. Quadruple antibiotics...

10.1080/19490976.2022.2112882 article EN cc-by Gut Microbes 2022-08-18

Summary Soy protein, one of the most commonly used raw materials for texturised vegetable has an important influence on soy protein (TSP) with its 7S and 11S fractions. In this study, proteins were extracted from soybean isolate added back to material prepare TSP analyse effect both physical properties TSP. The results showed that addition 5% 7s or 11s increased water‐holding capacity (up 9.04%) rehydration rate 25.71%) Compared adding a faster at lower temperature (30 45 °C). After...

10.1111/ijfs.15787 article EN International Journal of Food Science & Technology 2022-04-22

Barley (Hordeum vulgare L.) β-glucan (BBG) is of interest as a result its health benefits, but BBG presents significant disruptions on the gluten network, with negative impact food texture. To clarify interaction between and in dough, dynamic rheological, thermochemical process microstructure dough during heating were detected. The results showed that delayed thermopolymerization reaction affected polymerization specific molecular weight protein subunits. These impacts depended upon...

10.1021/acs.jafc.7b02011 article EN Journal of Agricultural and Food Chemistry 2017-07-03

Mucin-2 (MUC2) secreted by goblet cells participates in the intestinal barrier, but its mechanism acute necrotizing pancreatitis (ANP) remains unclear. In (AP) patients, functions of (MUC2, FCGBP, CLCA1, and TFF3) decreased, MUC2 was negatively correlated with AP severity. ANP rats treated pilocarpine (PILO) (PILO+ANP rats) to deplete showed more serious pancreatic colonic injuries, cell dysfunction, gut dysbiosis, bacterial translocation than those rats. GC-MS analysis feces that PILO+ANP...

10.1096/fj.202201998r article EN The FASEB Journal 2023-05-30

Bitter peptides in the enzymatic hydrolysates were prepared and purified from wheat gluten using aqueous ethanol solutions macroporous resin, which has opened a new road for extraction separation of bitter peptides. This report contains release regularity factors affecting change intensity during hydrolysis, providing scientific basis research on debitterizing method. In this study, effects different degrees hydrolysis (DH) enzyme active sites peptide content taste thresholds discussed. The...

10.3389/fnut.2022.1022257 article EN cc-by Frontiers in Nutrition 2022-10-04

We demonstrate that AP patients and experimental mice exhibited a dysfunction of Paneth cells. Our in vivo research showed the severity was exacerbated by long-term cells, which associated with gut microbiota disorder.

10.1128/msystems.01507-21 article EN mSystems 2022-05-02

Summary The effect of adding barley ( Hordeum vulgare L .) β‐glucan BBG ) to dough on the water redistribution and thermal properties was studied by TGA DSC . Combined with LF ‐ NMR analyse competition mechanism at 1 H level. mass loss measured reduced an average 2.11% added. increased retention dough, delayed process. results showed that same absorption T 21 3% longer while its 22 shorter than those control. has different effects states in dough. free sulfhydryl content during heating,...

10.1111/ijfs.14033 article EN International Journal of Food Science & Technology 2018-11-25

Gastric cancer (GC) is prevalent and aggressive, especially when patients have distant lung metastases, which often places into advanced stages. By identifying prognostic variables for metastasis in GC patients, it may be possible to construct a good prediction model both overall survival (OS) the cumulative incidence (CIP) plot of tumour.

10.4240/wjgs.v16.i2.357 article EN World Journal of Gastrointestinal Surgery 2024-02-25

We previously reported that acute necrotizing pancreatitis (ANP) after normal or high-fat diet is associated with a decreased number of Paneth cells in ileal crypts. Here, we ablated rat model ANP and to investigate the effects on disease symptoms. Adult male Sprague-Dawley rats received standard chow for 2 weeks, which they were treated dithizone deplete cells. Six hours later, was established by retrograde injection sodium taurocholate into biliopancreatic duct. Rats sacrificed at 6, 12,...

10.1155/2019/8474523 article EN cc-by Mediators of Inflammation 2019-11-11

Severe Acute pancreatitis(SAP) is associated with high rates of mortality and morbidity. Chitosan oligosaccharides(COS) are an agent antioxidant properties. We developed porous COS@SiO2 nanocomposites to study the protective effects mechanisms COS nanomedicine for treatment AP. Porous could release slowly in way pH control, so as achieve purpose sustained keep drug at a higher concentration. This aimed determine whether nanocomposites(COS@SiO2) ameliorate severe acute pancreatitis lung...

10.3389/fchem.2020.00720 article EN cc-by Frontiers in Chemistry 2020-10-07

A high-performance liquid chromatography (HPLC) method was developed for the separation of lovastatin (LT) and its derivatives. The conversion LT derivatives in alkaline or acidic solution different storage times also investigated by HPLC. results showed that present forms: as a lactone, acid (LA), methyl ester (LM) under condition. Well-resolved peaks three forms compounds were separated on Symmetry C18 column (4.6 × 250 mm i.d., particle size 5 µm) using acetonitrile.water (77:23, v/v)...

10.1093/chromsci/48.8.631 article EN Journal of Chromatographic Science 2010-09-01

Fat replacers prepared from polysaccharides and proteins possess functional properties of both proteins. In this study, an aqueous system barley β-glucan (BBG) gluten was prepared. The interactions between BBG (with/without extrusion modification) were studied. Triple analysis methods, including differential scanning calorimetry (DSC), thermogravimetric (TGA), low-field nuclear magnetic resonance (LF-NMR), utilized to analyze the freezing-thawing thermal evaporation process, as well...

10.1002/jsfa.12701 article EN Journal of the Science of Food and Agriculture 2023-05-13

Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes peripheral blood M1 and M2 monocytes HTGP patients. A total 90 subjects were enrolled, among which 16 diagnosed with HTGP, 34 biliary (ABP), 20 hypertriglyceridemia (HTG), healthy controls (HC). Peripheral CD14+CD86+ CD14+CD206+...

10.1155/2019/5705782 article EN cc-by Gastroenterology Research and Practice 2019-06-10
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