A5063829918- RNA Interference and Gene Delivery
- Neurobiology and Insect Physiology Research
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Insect and Arachnid Ecology and Behavior
- Insect Utilization and Effects
- Cancer Research and Treatments
- Cell death mechanisms and regulation
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Invertebrate Immune Response Mechanisms
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Insect Resistance and Genetics
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Retinoids in leukemia and cellular processes
- Cytokine Signaling Pathways and Interactions
- Advanced biosensing and bioanalysis techniques
South China Agricultural University
2016-2025
Hechi University
2024-2025
People's Hospital of Shiyan
2025
Shenzhen Polytechnic
2025
Ningbo University
2024
Chongqing University
2021-2023
Shanghai Jiao Tong University
2014-2023
Chongqing Cancer Hospital
2017-2023
Washington University in St. Louis
2015-2023
Shanghai Chest Hospital
2020-2023
MicroRNAs (miRNAs) are known to be involved in carcinogenesis and tumor progression hepatocellular carcinoma (HCC). Recently, microRNA-7 (miR-7) has been proven play a substantial role glioblastoma breast cancer, but its functions the context of HCC remain unknown. Here, we demonstrate that miR-7 inhibits cell growth metastasis vitro vivo . We first screened identified novel target, phosphoinositide 3-kinase catalytic subunit delta (PIK3CD). Overexpression would specifically markedly...
To measure the global impact of COVID-19 pandemic on volumes IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at height (March 1 to June 30, 2020) compared with 2 control 4-month periods.We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, 457 centers. Diagnoses were identified by their ICD-10 codes or classifications in databases.There 91,373 admissions immediately before 80,894 during months, representing an...
The efficacy of cisplatin in cancer chemotherapy is limited by the development resistance. Although molecular mechanisms involved chemoresistance are poorly understood, cellular response to known involve activation MAPK and other signal transduction pathways. An understanding early events could be valuable for improving therapy. We compared cisplatin-induced three MAPKs, JNK, p38, ERK, a cisplatin-sensitive human ovarian carcinoma cell line (2008) its resistant subclone (2008C13). JNK p38...
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell (ALCL) frequently carries the t(2;5)(p23;q35) resulting in aberrant expression of chimeric nucleophosmin-ALK. Previously, nucleophosmin-ALK has been shown to activate phosphatidylinositol 3-kinase (PI3K) and its downstream effector, serine/threonine AKT. In this study, we hypothesized that mammalian target rapamycin (mTOR) pathway, which functions AKT, mediates oncogenic effects activated PI3K/AKT ALK+ ALCL. Here, provide...
Autophagy is finely regulated at multiple levels and plays crucial roles in development disease. In the fat body of silkworm, Bombyx mori, autophagy occurs Atg gene expression peaks during nonfeeding molting pupation stages when steroid hormone (20-hydroxyecdysone; 20E) high. Injection 20E into feeding larvae upregulated genes reduced TORC1 activity resulting induction body. Conversely, RNAi knockdown receptor partner (USP) or targeted overexpression a dominant negative mutant (EcR (DN) )...
Previous studies revealed that there existed great individual variations of gut microbiota in mice, and the bacteria mice were changed with occurrence development diseases. To identify core healthy explore their relationships host phenotypes would help to understand underlying mechanisms. In this study, we identified 37 genus-level from feces 101 different ages, sexes, mouse strains three previous studies. They collectively represented nearly half total sequences, predominantly included...
The ATP-binding cassette (ABC) transporter superfamily is the largest gene family responsible for transporting specific molecules across lipid membranes in all living organisms. In insects, ABC transporters not only have important functions molecule transport, but also play roles insecticide resistance, metabolism and development. From genome of silkworm, Bombyx mori, we identified 51 putative genes which are classified into eight subfamilies (A-H) by phylogenetic analysis. Gene duplication...
Phosphatase and tensin homologue (PTEN), as a tumor suppressor, plays vital roles in tumorigenesis progression of prostate cancer. However, the mechanisms PTEN regulation still need further investigation. We here report that combination four microRNAs (miR-19b, miR-23b, miR-26a miR-92a) promotes cell proliferation by regulating its downstream signals vitro. found (miRNAs) could effectively suppress expression directly interacting with 3' UTR epithelial cancer cells. Under-expression miRNAs...
Hypertriglyceridemia (HTG) aggravates the course of acute pancreatitis (AP). Intestinal barrier dysfunction is implicated in pathogenesis AP during which dysbiosis intestinal microbiota contributes to barrier. However, few studies focus on changes intestine HTG-related necrotizing (ANP). Here, we investigated and Paneth cell antimicrobial peptides (AMPs) ANP (HANP) rats. Rats fed a high-fat diet induce HTG was induced by retrograde injection 3.5% sodium taurocholate into biliopancreatic...
Intestinal barrier dysfunction plays an important role in acute necrotizing pancreatitis (ANP) and intestinal microbiota dysbiosis was involved failure. Paneth cells protect are associated with microbiota. Here, we investigated changes antimicrobial peptides of ileum during ANP.Rats ANP were established by retrograde injection 3.5% sodium taurocholate into biliopancreatic duct sacrificed at 24h 48h, respectively. Injuries pancreas distal evaluated histopathological score. function assessed...
Abstract Background Tumor repopulation is a major cause of radiotherapy failure. Previous investigations highlighted that dying tumor cells played vital roles in through promoting proliferation the residual repopulating (TRCs). However, TRCs also suffer DNA damage after radiotherapy, and might undergo mitotic catastrophe under stimulation proliferative factors released by cells. Hence, we intend to find out how these paradoxical biological processes coordinated potentiate radiotherapy....
Modulation of nutrient digestion and absorption is one the post-ingestion mechanisms that guarantees best exploitation food resources, even when they are nutritionally poor or unbalanced, plays a pivotal role in generalist feeders, which experience an extreme variability diet composition. Among insects, larvae black soldier fly (BSF), Hermetia illucens, can grow on wide range feeding substrates with different content, suggesting set motion processes to match their nutritional requirements....
Tumor cell repopulation after radiotherapy is a major cause for the tumor radioresistance and recurrence. This study aims to investigate underlying mechanism of radiotherapy, with focus on whether how necroptosis takes part in this process.Necroptosis irradiation were examined vitro vivo. And growth-promoting effect necroptotic cells was investigated by chemical inhibitors or shRNA against associated proteins genes vivo models. Downstream relevance factors identified western blot...
Cyclin-dependent kinase (CDK) inhibitor p27Kip1 binds to the cyclin E·CDK2 complex and plays a major role in controlling cell cycle growth. Our group others have reported that anti-HER2 monoclonal antibodies exert inhibitory effects on HER2-overexpressing breast cancers through G1 arrest associated with induction of reduction CDK2. The antibody-induced growth inhibition is, however, still uncertain. Here we provided several lines evidence supporting critical for tumor inhibition. Induction...
Abstract Background Insect innate immunity can be affected by juvenile hormone (JH) and 20-hydroxyecdysone (20E), but how is developmentally regulated these two hormones in insects has not yet been elucidated. In the silkworm, Bombyx mori , JH 20E levels are high during final larval molt (4 M) absent feeding stage of 5 th instar (5 F), while level low prepupal (PP). Fat body produces humoral response molecules hence considered as major organ involved immunity. Results A genome-wide...
Autophagy and apoptosis, which could be induced by common stimuli, play crucial roles in development disease. The functional relationship between autophagy apoptosis is complex, due to the dual effects of autophagy. In Bombyx Bm-12 cells, 20-hydroxyecdysone (20E) treatment or starvation-induced cell death, with preceding apoptosis. response 20E starvation, BmATG8 was rapidly cleaved conjugated PE form BmATG8-PE; subsequently, BmATG5 BmATG6 were into BmATG5-tN BmATG6-C, respectively....
Juvenile hormone (JH) biosynthesis in the corpus allatum (CA) is regulated by neuropeptides and neurotransmitters produced brain. However, little known about how these neural signals induce changes JH biosynthesis. Here, we report a novel function of TGFβ signaling transferring brain into transcriptional acid methyltransferase (jhamt), key regulatory enzyme A Drosophila genetic screen identified that Tkv Mad are required for JH-mediated suppression broad (br) expression young larvae. Further...