A5102836040- Acute Ischemic Stroke Management
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Climate Change and Health Impacts
- RNA Research and Splicing
- Intracranial Aneurysms: Treatment and Complications
- Advanced Technologies and Applied Computing
- Genetic Neurodegenerative Diseases
- Infectious Encephalopathies and Encephalitis
- Biomarkers in Disease Mechanisms
- Retinal and Optic Conditions
- Antifungal resistance and susceptibility
- Peripheral Artery Disease Management
- Cell Adhesion Molecules Research
- Autoimmune Neurological Disorders and Treatments
- Brain Metastases and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac tumors and thrombi
- Neurological Disorders and Treatments
- COVID-19 Clinical Research Studies
- Neurological Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
Kyoto first Red Cross hospital
2015-2024
Japanese Red Cross Society Kyoto Daini Hospital
2021-2023
Memorial Hospital
2023
National Neuroscience Institute
2023
National Center of Neurology and Psychiatry
2023
Boston Medical Center
2021-2022
Boston University
2021-2022
Hospital de Clínicas de Porto Alegre
2021
Grady Memorial Hospital
2021
Universidade Federal do Rio Grande do Sul
2021
To measure the global impact of COVID-19 pandemic on volumes IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at height (March 1 to June 30, 2020) compared with 2 control 4-month periods.We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, 457 centers. Diagnoses were identified by their ICD-10 codes or classifications in databases.There 91,373 admissions immediately before 80,894 during months, representing an...
The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide.We sought measure global impact on volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at height (1 March-31 May 2020) compared with two control periods (immediately preceding one year prior).Retrospective, observational, international study, across 6 continents, 40 countries, 187 comprehensive stroke centers. diagnoses were...
IntroductionWe investigated the clinical characteristics and outcomes of stroke in SARS-CoV-2 infected patients Japan.MethodsThis prospective, multicenter observational study with infection involving 563 primary centers across Japan was conducted between July 2020, May 2022. We included 159 cases (131 ischemic stroke, 2 transient attack (TIA), 21 intracranial hemorrhage, 5 subarachnoid hemorrhage) collected their characteristics. Ischemic TIA (n = 133) were analyzed separately.ResultsThe...
We herein report a patient who developed transient prosopometamorphopsia restricted to the left eye caused by ischemia of right splenium corpus callosum. A 66-year-old right-handed woman suddenly noticed that eyes people she encountered appeared markedly adducted their noses. On emergent admission, neurological and ophthalmological examinations revealed no abnormalities. Diffusion-weighted magnetic resonance imaging showed small, hyperintense lesion at In this case, information on visual...
A 41-year-old man presented with gradually progressing proximal-dominant lower limb atrophy and weakness. His brother, mother maternal aunt had the same symptoms. physical examination muscle imaging (CT ultrasound) showed selective involvement of bilateral paraspinal, gluteus posterior groups muscles. Based on characteristic pattern, clinical findings biopsy results, we made a straightforward diagnosis limb-girdle muscular dystrophy (LGMD) due to DNAJB6 Phe93Leu mutation based targeted gene...
30歳女性．失語症状後に抑うつ傾向となり，最初の医療施設に入院した．急性辺縁系脳炎を疑い，ステロイドパルス療法を実施するも改善なく，入院同日より幻覚や精神運動興奮などの精神症状が出現した．血漿交換療法と免疫グロブリン静注療法の追加も無効であり，精神症状が強く一般病棟での管理は困難となった．第17病日に他院精神科病棟に転院となった．ステロイドパルス療法と長期ステロイド経口投与および精神科治療により，症状は徐々に改善し第143病日に自宅退院できた．臨床経過および抗甲状腺抗体と抗NAE抗体の存在より橋本脳症と診断した．本例では精神科治療下での長期ステロイド経口投与が唯一有効であった．
Objective: This study was conducted to clarify the characteristics of preprocedural vascular images in patients with acute embolic occlusion carotid artery whom internal (ICA) could be recanalized by manual suction syringe via balloon guiding catheter (SS-BGC) alone.
【背景および目的】中大脳動脈水平部開存型の内頸動脈閉塞症(ICOPM)に対する急性期血行再建術(EVT)の成績と転帰関連因子を明らかにする.【方法】2014年5月から2021年7月にEVTを実施した511例中,ICOPM例を対象とし,背景因子と時間指標,治療内容,手術成績を検討した.対象を転帰良好群(3カ月後mRS 0–2:G群)と転帰不良群(同3–6:P群)に分類し,比較した.【結果】対象は36例で年齢85歳,NIHSS 17.5点,発症–来院時間200分,穿刺–再開通時間(P2R)84.5分(中央値),術中血栓移動9例,有効再開通32例であった.G群は13例でP群と比較しP2Rが短かった.【結論】EVTを受けたICOPM例は36例で,有効再開通32例,転帰良好13例と成績不良ではなかった.転帰良好例ではP2Rが短かったが,ICOPMは複雑な病態であり,P2R短縮が転帰改善に直結するとはいえない.
症例は87歳女性.意識障害と右片麻痺をみとめ,当院に搬送された.頭部CTおよびCT angiographyにて左中大脳動脈(MCA)閉塞による脳梗塞と診断し,rt-PA静注先行のもと,血栓回収術を実施した.左MCA水平部(M1)はステントリトリーバー(SR)と吸引カテーテルにて1passで再開通するも,島部(M2)は再閉塞を繰り返した.最終的にSRにて3passしたが,部分再開通にとどまった.左大脳半球は広範囲梗塞に陥り,第4病日に死亡した.病理解剖にて,複数の頭蓋内動脈での強い動脈硬化性変化とともに,左M1遠位部の粥腫と同部位の動脈解離をみとめた.後者は,動脈硬化の強い血管に対してSRを使用したことによる医原性脳動脈解離と考えられた.動脈硬化の強い高齢者の血栓回収術中に再閉塞を繰り返す場合は,術中の医原性脳動脈解離に留意すべきである.
【目的】吸引カテーテル(AC)を用いた脳血栓回収療法(AC-MT)の成績と,first pass(FP)手技による違いを明らかにする.【方法】2019年4月から2020年9月までの当施設でのAC-MT連続例を対象とした.対象全体の成績を検討し,FP手技で二群に分け(AC単独手技:SAT群,ステントリトリーバー併用手技:CBT群),成績を比較した.【結果】対象は78例あり,FP後の有効再開通(mTICI 2b–3)は29例(37%),終了時点の有効再開通は73例(94%),転帰良好例(3カ月後mRS 0–2)は34例(44%)であった.35例のSAT群では43例のCBT群と比較し,有効再開通例数に差はなく(94%,93%),再開通時間が短い傾向にあり(33分, 57分),転帰良好例が多かった(57%,33%).【結論】AC-MTにおいてSAT群ではCBT群と比較し,再開通時間が短く,転帰良好例が多かった.
Laminopathy is muscular dystrophy caused by an LMNA gene mutation. It characterized cardiac disease such as atrial fibrillation. We report a case of laminopathy in 49-year-old woman who presented with cardiogenic stroke. She had experienced weakness her limb-girdle muscles since childhood, fibrillation, cardiomyopathy, and mild contracture the ankle joints, familial history heart disease. Gene analysis identified novel heterozygous variant, c. 1135C>A (p.Leu379Ile), gene. can be...
The objectives of this study were to measure the global impact pandemic on volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at height (March 1 June 30, 2020) compared with two control 4-month periods.
Endovascular treatment (EVT) for large vessel occlusion in acute ischemic stroke patients during the SARS-CoV-2 epidemic requires implementation of an in-hospital system to guard against infection. Changes this may be needed upon aggravation a particular region. The objective study was clarify present state infection protection and effects change EVT at single institution.
70 歳男性.X-3 年に右下葉結節切除術を受け,肺多形癌と診断された.X-2 年の抗癌剤併用後もリンパ節や脳に転移し,X-1 年 10 月からニボルマブが開始された.同年 12 月に脳梗塞で入院したが,経胸壁心エコーで塞栓源はなかった.後遺症なく退院し,転移巣は著明に縮小したが,X 5 月にてんかん性発作で再入院し,脳梗塞巣の新規増加が確認された.経胸壁心エコーにて僧帽弁の可動性腫瘤が見つかり,腫瘤摘出術を実施した.腫瘤は非細菌性血栓性心内膜炎(NBTE)と病理診断された.本例では,ニボルマブにて肺癌の進行をコントロールできている最中に,NBTE による脳梗塞を来した.同薬に NBTE の予防効果は期待できず,今後は同様の経過を呈する脳梗塞例の増加が危惧される.