Sunil A. Sheth
A5000212230- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Peripheral Artery Disease Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Retinal Imaging and Analysis
- Neurosurgical Procedures and Complications
- Medical Imaging and Analysis
- Neurological Disease Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- Medical Image Segmentation Techniques
- Neurological Complications and Syndromes
- COVID-19 and healthcare impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Imaging and Diagnostics
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neural Engineering
- Mitochondrial Function and Pathology
- Neurological Disorders and Treatments
The University of Texas Health Science Center at Houston
2017-2025
University of Houston
2018-2025
Klinikum Ludwigshafen
2024
Boston University
2021-2024
Boston Medical Center
2021-2024
University of Pittsburgh Medical Center
2024
Centers for Disease Control and Prevention
2024
National Center for Emerging and Zoonotic Infectious Diseases
2024
Neurology, Inc
2014-2024
Universidad Científica del Sur
2024
Advanced imaging for patient selection in mechanical thrombectomy is not widely available.To compare the clinical outcomes of patients selected by noncontrast computed tomography (CT) vs those perfusion (CTP) or magnetic resonance (MRI) extended time window.This multinational cohort study included consecutive with proximal anterior circulation occlusion stroke presenting within 6 to 24 hours last seen well from January 2014 December 2020. This was conducted at 15 sites across 5 countries...
Abstract Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant traditional pharmacological therapies. However, many nerve targets, this requires invasive surgeries and implantation bulky (about a few centimetres in at least one dimension). Here we report design vivo proof-of-concept testing an endovascular wireless battery-free millimetric implant stimulation specific difficult reach via surgeries. The device can...
To measure the global impact of COVID-19 pandemic on volumes IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at height (March 1 to June 30, 2020) compared with 2 control 4-month periods.We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, 457 centers. Diagnoses were identified by their ICD-10 codes or classifications in databases.There 91,373 admissions immediately before 80,894 during months, representing an...
Reperfusion without functional independence (RFI) is an undesired outcome following thrombectomy in acute ischemic stroke. The primary objective was to evaluate, patients presenting with proximal anterior circulation occlusion stroke the extended time window, whether selection computed tomography (CT) perfusion or magnetic resonance imaging associated RFI, mortality, symptomatic intracranial hemorrhage (sICH) compared noncontrast CT selected patients.The CLEAR study (CT for Late Endovascular...
BACKGROUND: The optimal management of patients with isolated posterior cerebral artery occlusion is uncertain. We compared clinical outcomes for endovascular therapy (EVT) versus medical (MM) in occlusion. METHODS: This multinational case-control study conducted at 27 sites Europe and North America included consecutive presenting within 24 hours time last well from January 2015 to August 2022. Patients treated EVT or MM were multivariable logistic regression inverse probability treatment...
Approximately 10% to 20% of large vessel occlusion (LVO) strokes involve tandem lesions (TLs), defined as concomitant intracranial LVO and stenosis or the cervical internal carotid artery. Mechanical thrombectomy (MT) may benefit patients with TLs; however, optimal management procedural strategy lesion remain unclear.
Background Mechanical thrombectomy has been shown to be effective in patients with acute ischemic stroke secondary large‐vessel occlusion and small moderate infarct volume. However, there are no randomized clinical trials for large‐core volume comparing mechanical medical therapy the population selected based solely on noncontrast computed tomography brain scan. The TESLA (Thrombectomy Emergent Salvage of Large Anterior Circulation Ischemic Stroke) trial is designed address this question....
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Acute ischemic stroke (AIS) caused by distal medium vessel occlusions (DMVOs) represents a significant proportion of overall cases. While intravenous thrombolysis (IVT) has been primary treatment, advancements in endovascular procedures have led to increased use mechanical thrombectomy (MT) DMVO patients. However, symptomatic intracerebral hemorrhage (sICH) remains critical complication AIS, particularly after undergoing intervention. This study aims identify factors associated with sICH patients MT.
Background The efficacy of endovascular treatment (EVT) in acute ischaemic stroke due to distal medium vessel occlusion (DMVO) remains uncertain. Our study aimed evaluate the safety and EVT compared with best medical management (BMM) DMVO. Methods In this prospectively collected, retrospectively reviewed, multicentre cohort study, we analysed data from Multicentre Analysis primary Distal occlusions: effect Mechanical Thrombectomy registry. Patients DMVO M2, M3 M4 segments who underwent or...
Objective Faster time from onset to recanalization (OTR) in acute ischemic stroke using endovascular therapy (ET) has been associated with better outcome. However, previous studies were based on less‐effective first‐generation devices, and analyzed only dichotomized disability outcomes, which may underestimate the full effect of treatment. Methods In combined databases SWIFT STAR trials, we identified patients treated Solitaire stent retriever achievement substantial reperfusion...
an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) international outbreak.The World Health Organization designated this as a global pandemic on March 11, 2020, with over 200 countries affected worldwide.As of April 24, there were 790 986 patients confirmed COVID-19 and 195 775 deaths worldwide, the United States, Spain, Italy, France, Germany, Kingdom, Turkey, Iran surpassing China in number cases. 1 In consecutive series 221 admitted to hospital...
Background and Purpose- The availability of expertise to interpret advanced neuroimaging recommended in the guideline-based endovascular stroke therapy (EST) evaluation are limited. Here, we develop validate an automated machine learning-based method that evaluates for large vessel occlusion (LVO) ischemic core volume patients using a widely available modality, computed tomography angiogram (CTA). Methods- From our prospectively maintained registry electronic medical record, identified with...
Background and Purpose- Recent landmark trials provided overwhelming evidence for effectiveness of endovascular stroke therapy (EST). Yet, the impact these on clinical practice EST among lower volume centers remains poorly characterized. Here, we determine population-level patterns in performance US hospitals compare outcomes from higher versus centers. Methods- Using validated diagnosis codes data all discharges Emergency Rooms Florida (2006-2016) National Inpatient Sample (2012-2016)...
Successful reperfusion is one of the strongest predictors functional outcomes after mechanical thrombectomy (MT). Despite continuous advancements in MT technology and techniques, failure still occurs ≈15% to 30% patients with large vessel occlusion strokes undergoing MT. We aim evaluate safety efficacy rescue intracranial stenting for stroke failed MT.The SAINT (Stenting Angioplasty Neurothrombectomy) Study a retrospective analysis prospectively collected data from 14 comprehensive centers...
Background A better understanding of real‐world practice patterns in the endovascular treatment for large vessel occlusion acute ischemic stroke is needed. Here, we report methods and initial results Society Vascular Interventional Neurology (SVIN) Registry. Methods The SVIN Registry an ongoing prospective, multicenter, observational registry capturing patients with undergoing since November 2018. Participating sites also contributed pre‐SVIN data collected per institutional prospective...
The benefit of endovascular stroke therapy (EVT) in large vessel occlusion (LVO) ischemic is highly time dependent. Process improvements to accelerate in-hospital workflows are critical.
There is uncertainty whether patients with large vessel occlusion (LVO) presenting in the late 6-hour to 24-hour time window can be selected for endovascular therapy (EVT) by noncontrast CT (NCCT) and angiography (CTA) LVO detection. We evaluated clinical outcomes of EVT NCCT compared those medically managed extended window.