A5043587613- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Chromatin Remodeling and Cancer
- Neurofibromatosis and Schwannoma Cases
- Adipose Tissue and Metabolism
- Gestational Trophoblastic Disease Studies
- Chronic Lymphocytic Leukemia Research
- Adrenal and Paraganglionic Tumors
- Head and Neck Surgical Oncology
- Eosinophilic Disorders and Syndromes
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Advanced Memory and Neural Computing
- Chronic Myeloid Leukemia Treatments
- Testicular diseases and treatments
- MicroRNA in disease regulation
- Renal and related cancers
The University of Texas Medical Branch at Galveston
2021-2025
Henry Ford Hospital
2015-2023
Barrow Neurological Institute
2019-2020
Henry Ford Health System
2014-2019
Michigan United
2019
St. Joseph's Hospital and Medical Center
2019
Children's Hospital of Los Angeles
2014
University of California, San Francisco
2012-2013
Abstract Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant traditional pharmacological therapies. However, many nerve targets, this requires invasive surgeries and implantation bulky (about a few centimetres in at least one dimension). Here we report design vivo proof-of-concept testing an endovascular wireless battery-free millimetric implant stimulation specific difficult reach via surgeries. The device can...
Pediatric glioblastomas (GBM) are highly aggressive and lethal tumors. Recent sequencing studies have shown that ~30 % of pediatric GBM ~80 diffuse intrinsic pontine gliomas show K27M mutations in the H3F3A gene, a variant encoding histone H3.3. lead to global reduction H3K27me3. Our goal was develop biomarkers for histopathologic detection these Therefore, we evaluated utility measuring H3K27me3 as prognostic biomarker tested an antibody directed specifically against H3.3 mutation 290...
Treatment of the tumor and dural margin with surgery sometimes radiation are cornerstones therapy for meningioma. Molecular classifications have provided insights into biology disease; however, response to treatment remains heterogeneous. In this study, we used retrospective data on 2,824 meningiomas, including molecular 1,686 tumors 100 prospective from RTOG-0539 phase 2 trial define biomarkers response. Using propensity score matching, found that gross resection was associated longer...
Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy (ExM) variants have been used to separate proteins from each other preserved biospecimens, improving antibody access epitopes. Here, we present an ExM variant, decrowding expansion pathology (dExPath), that can expand away human brain specimens, including formalin-fixed paraffin-embedded (FFPE) clinical specimens. Immunostaining of dExPath-expanded specimens reveals, with nanoscale...
Trimethylation of histone 3 lysine 9 (H3K9me3) is a marker repressed transcription. Cells transfected with mutant isocitrate dehydrogenase (IDH) show increased methylation residues, including H3K9me3, because inhibition demethylases by 2-hydroxyglutarate. Here, we evaluated H3K9me3 and its association IDH mutations in 284 gliomas. H3K9 was significantly associated oligodendrogliomas. Moreover, 72% World Health Organization grade II 65% III oligodendrogliomas showed combined positivity 1p19q...
BACKGROUND Malignant peripheral nerve sheath tumors (MPNSTs) are rare and highly malignant of neural crest origin. No matter their anatomical location, they difficult to treat carry a poor prognosis. OBSERVATIONS This report highlights the complexities diagnosis management patient with MPNST cauda equina. The tumor retained expression H3K27me3, which is expected in spinal MPNSTs but uncommon most sporadic neurofibromatosis type 1–driven MPNSTs. LESSONS described diagnostic nuance should be...
X-linked adrenoleukodystrophy (X-ALD) is a progressive neurometabolic disease caused by mutations/deletions in the Abcd1 gene. Similar gene often result diagonally opposing phenotypes of mild adrenomyeloneuropathy and severe neuroinflammatory cerebral (ALD), which suggests involvement downstream modifier genes. We recently documented first evidence loss AMP-activated protein kinase α1 (AMPKα1) ALD patient-derived cells. Here, we report novel AMPKα1 postmortem brain white matter patients with...
IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory condition which often shows dramatic response to steroid therapy. IgG4-RD can present either as single lesion or systemic multi-organ disorder. Common histological findings include dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and phlebitis. Although diagnostic criteria for have been proposed many organs/sites, they are not well established the central nervous system....
Abstract X-linked adrenoleukodystrophy is a severe demyelinating neurodegenerative disease mainly affecting males. The cerebral (cALD) phenotype has poor prognosis and underlying mechanism of onset progression neuropathology remains poorly understood. In this study we aim to integrate metabolomic microRNA (miRNA) datasets identify variances associated with cALD. Postmortem brain tissue samples from five healthy controls (CTL) cALD patients were utilized in study. White matter ALD was...
In the current neurosurgical and anatomical literature, intracanalicular segment of ophthalmic artery (OphA) is usually described to be within optic nerve dural sheath (ONDS), implying direct contact between inside canal. present study, authors sought clarify exact relationship OphA ONDS.
Abstract Aims Resource‐strained healthcare ecosystems often struggle with the adoption of World Health Organization (WHO) recommendations for classification central nervous system (CNS) tumors. The generation robust clinical diagnostic aids and advancement simple solutions to inform investment strategies in surgical neuropathology would improve patient care these settings. Methods We used information theory calculations on a brain cancer simulation model real‐world data sets compare...
Blast phase in chronic myelogenous leukemia (CML) has rarely been reported to involve extramedullary sites like skin, lymph nodes, and central nervous system. Clinical history, characteristic hematologic findings (elevated leukocyte counts, myelocytic predominance, basophilia), Philadelphia chromosome are of high diagnostic significance especially isolated presentations. We describe a unique case CML relapse with blast involving the eye. A 66-year-old man known diagnosis on imatinib...
Background: Blood-brain barrier (BBB) breakdown is a crucial aspect of Alzheimer’s disease (AD) progression. Dysfunction in BBB primarily caused by impaired tight junction and adherens proteins brain microvascular endothelial cells (BMECs). The role junctions AD-related dysfunction remains unclear. Exosomes from senescent have unique characteristics contribute to modulating the phenotype recipient cells. However, it unknown if how these exosomes cause BMEC AD. Objective: This study aimed...
ABSTRACT To understand how genomic heterogeneity of glioblastoma (GBM) contributes to the poor response therapy, which is characteristic this disease, we performed DNA and RNA sequencing on GBM tumor samples neurospheres orthotopic xenograft models derived from them. We used resulting data set show that somatic driver alterations including single nucleotide variants, focal alterations, oncogene amplification in extrachromosomal (ecDNA) elements were majority propagated model systems. In...
The distinction of multifocal versus multicentric gliomas can conceivably have important therapeutic implications. We present a 27-year-old man with two radiologically distinct non-enhancing infiltrative masses in the anterior frontal lobe and posterior temporoparietal region. No intervening disease was evident on MRI modalities; lesions were stable over period many months. He underwent separate resections few months apart. Given question whether his tumors represented de novo primary or one...
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently identified diagnosis that can cause variety of severe symptoms, including ataxia, dysarthria, diplopia, paraparesis, and vertigo. These symptoms rarely present in isolation but often accompany one another various combinations. Magnetic Resonance Imaging (MRI) the brain critical for making typically reveals scattered within pons adjacent structures. The syndrome responds well...
Abstract Minimally invasive neural interfaces can be used to diagnose, manage, and treat many disorders with substantially reduced risks of surgical complications. Endovascular implanted in the veins or arteries is one approach, but it requires prescriptions anti-thrombotic medication are likely not explantable after endothelialization. More critically, approach limited by small size location blood vessels, such that important cortical, subcortical, spinal targets cannot reached. Here, we...