Pablo Harker
A5017338892- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Peripheral Artery Disease Management
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Aortic aneurysm repair treatments
- Soft Robotics and Applications
- Moyamoya disease diagnosis and treatment
- Micro and Nano Robotics
- Social Media in Health Education
- Vascular Anomalies and Treatments
- Pituitary Gland Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurofibromatosis and Schwannoma Cases
- Otitis Media and Relapsing Polychondritis
- Characterization and Applications of Magnetic Nanoparticles
- Medical research and treatments
- Neurosurgical Procedures and Complications
- Meta-analysis and systematic reviews
- Consumer Attitudes and Food Labeling
- Aortic Disease and Treatment Approaches
University of Cincinnati
2021-2025
University of Cincinnati Medical Center
2022-2025
Harvard University
2020-2023
Massachusetts General Hospital
2020-2023
Brigham and Women's Hospital
2022
Hospital Universitario San Ignacio
2017-2019
Cincinnati Children's Hospital Medical Center
2019
Pontificia Universidad Javeriana
2017
John Radcliffe Hospital
1975
University of Oxford
1975
Advances in robotic technology have been adopted various subspecialties of both open and minimally invasive surgery, offering benefits such as enhanced surgical precision accuracy with reduced fatigue the surgeon. Despite advantages, applications to endovascular neurosurgery remained largely unexplored because technical challenges miniaturization devices that can reach complex tortuous vasculature brain. Although some commercial systems enable manipulation conventional guidewires for...
Significance Magnetic soft continuum robots (MSCRs) capable of magnetic field–controllable steering offer great promise for the endovascular treatment cardiovascular diseases. However, existing MSCRs are often limited to small workspaces because lack efficient design and optimization tools. In this work, we introduce an evolutionary strategy by integrating theoretical modeling genetic algorithm. Enabled strategy, proposed MSCR achieves optimal workspace much larger than those...
Importance The effects of moderate systolic blood pressure (SBP) lowering after successful recanalization with endovascular therapy for acute ischemic stroke are uncertain. Objective To determine the futility lower SBP targets (<140 mm Hg or 160 Hg) compared a higher target (≤180 Hg). Design, Setting, and Participants Randomized, open-label, blinded end point, phase 2, clinical trial that enrolled 120 patients who had undergone at 3 US comprehensive centers from January 2020 to...
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Acute ischemic stroke (AIS) caused by distal medium vessel occlusions (DMVOs) represents a significant proportion of overall cases. While intravenous thrombolysis (IVT) has been primary treatment, advancements in endovascular procedures have led to increased use mechanical thrombectomy (MT) DMVO patients. However, symptomatic intracerebral hemorrhage (sICH) remains critical complication AIS, particularly after undergoing intervention. This study aims identify factors associated with sICH patients MT.
Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients distal medium vessel occlusions (DMVO) are not well understood.
Acute ischemic stroke (AIS) from primary medium vessel occlusions (MeVO) is a prevalent condition associated with substantial morbidity and mortality. Despite the common use of mechanical thrombectomy (MT) in AIS, predictors poor outcomes MeVO remain poorly characterized.
Background The combination of intravenous thrombolysis (IVT) with mechanical thrombectomy (MT) may have clinical benefits for patients medium vessel occlusion. Purpose To examine whether MT combined IVT is associated different outcomes than alone in acute ischemic stroke (AIS) and Materials Methods This retrospective study included consecutive adult AIS occlusion treated or at 37 academic centers North America, Asia, Europe. Data were collected from September 2017 to July 2021. Propensity...
Background and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed evaluate safety efficacy DMVO patients treated with either MT-IVT or alone.Methods multinational analyzed data from 37 centers across North America, Asia, Europe. Patients AIS were included, collected September 2017...
Introduction: First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is significant predictor favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional and predictors FPE medium occlusions (MeVO) are scarce. Patients Methods: We conducted an international retrospective study MeVO cases. Multivariable logistic modeling was used to establish independent FPE. Clinical...
Background For acute proximal intracranial artery occlusions, contact aspiration may be more effective than stent‐retriever for first‐line reperfusion therapy. Due to the lack of data regarding medium vessel occlusion thrombectomy, we evaluated outcomes according technique in a large, multicenter registry. Methods Imaging, procedural, and clinical patients with occlusions (M2, A1, or P1) distal (M3, A2, P2, further) treated at 37 sites 10 countries were analyzed endovascular (stent‐retriever...
<title>Abstract</title> Purpose The trunk of the BA remains underrepresented in microsurgical studies. This study aims to address this gap by providing a detailed review BA's anatomy, proposing novel segmental classification artery and significance each segment various surgical pathologies approaches. Methods A total 20 cadaveric adult brain specimens were meticulously examined under high magnification, following Institutional Review Board approval. dissection focused on its branches, with...
Mechanical thrombectomy (MT) is established as an effective treatment for large vessel occlusion strokes, but its efficacy and safety medium occlusions (MeVOs) remain less clear. This study examines the impact of periprocedural embolization to a new vascular territory (ENT) on clinical outcomes in patients with MeVO stroke treated MT. A multicenter, retrospective analysis was conducted using MAD-MT (Multicenter Analysis primary Distal occlusions: effect Thrombectomy) registry, including 2122...
Open surgery has traditionally been preferred for the management of bifurcation middle cerebral artery (MCA) aneurysms. Flow diverting stents present a novel endovascular strategy aneurysm treatment.To add to limited literature describing outcomes and complications in use flow diverters treatment these complex aneurysms.This is multicenter retrospective review MCA aneurysms undergoing diversion. We assessed post-treatment radiological both thromboembolic hemorrhagic complications.We reviewed...
The Woven EndoBridge (WEB) device is a novel intrasaccular flow disruptor tailored for bifurcation aneurysms. We aim to describe the degree of aneurysm occlusion at latest follow-up, and rate complications aneurysms treated with WEB stratified according rupture status.Our data were taken from WorldWideWeb Consortium, an international multicenter cohort including patients device. Aneurysms classified into two groups: ruptured unruptured. compared clinical radiologic outcomes both groups....
BACKGROUND AND OBJECTIVES: Dual antiplatelet therapy (DAPT) is necessary to minimize the risk of periprocedural thromboembolic complications associated with aneurysm embolization using pipeline device (PED). We aimed assess impact platelet function testing (PFT) on reducing PED flow diversion in patients receiving aspirin and clopidogrel. METHODS: Patients unruptured intracranial aneurysms requiring were identified from 13 centers for retrospective evaluation. Clinical variables including...