Robert W. Regenhardt
A5061474894- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Neurosurgical Procedures and Complications
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Moyamoya disease diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disorders and Treatments
- MRI in cancer diagnosis
- Vascular Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- Cerebral Venous Sinus Thrombosis
- Neurological Disease Mechanisms and Treatments
- Advanced X-ray and CT Imaging
- Antiplatelet Therapy and Cardiovascular Diseases
Massachusetts General Hospital
2017-2025
Harvard University
2017-2025
Brigham and Women's Hospital
2018-2025
Presbyterian Hospital
2024
Cornell University
2024
Wockhardt (United States)
2018-2024
Université de Tours
2023
Beth Israel Deaconess Medical Center
2023
Stroke Association
2021-2023
Boston University
2023
It has been hypothesized that α-synuclein (αS) misfolding may begin in peripheral nerves and spread to the central nervous system (CNS), leading Parkinson disease related disorders. Although recent data suggest αS pathology can within mouse brain, there is no direct evidence for of from a site. In present study, we show hind limb intramuscular (IM) injection induce CNS human Ala53Thr (M83) wild-type (M20) transgenic (Tg) models. Within 2-3 mo after IM homozygous M83 Tg mice 3-4 hemizygous...
Advances in robotic technology have been adopted various subspecialties of both open and minimally invasive surgery, offering benefits such as enhanced surgical precision accuracy with reduced fatigue the surgeon. Despite advantages, applications to endovascular neurosurgery remained largely unexplored because technical challenges miniaturization devices that can reach complex tortuous vasculature brain. Although some commercial systems enable manipulation conventional guidewires for...
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Acute ischemic stroke (AIS) caused by distal medium vessel occlusions (DMVOs) represents a significant proportion of overall cases. While intravenous thrombolysis (IVT) has been primary treatment, advancements in endovascular procedures have led to increased use mechanical thrombectomy (MT) DMVO patients. However, symptomatic intracerebral hemorrhage (sICH) remains critical complication AIS, particularly after undergoing intervention. This study aims identify factors associated with sICH patients MT.
Background The efficacy of endovascular treatment (EVT) in acute ischaemic stroke due to distal medium vessel occlusion (DMVO) remains uncertain. Our study aimed evaluate the safety and EVT compared with best medical management (BMM) DMVO. Methods In this prospectively collected, retrospectively reviewed, multicentre cohort study, we analysed data from Multicentre Analysis primary Distal occlusions: effect Mechanical Thrombectomy registry. Patients DMVO M2, M3 M4 segments who underwent or...
Activation of angiotensin-converting enzyme 2 (ACE2), production angiotensin-(1-7) [Ang-(1-7)] and stimulation the Ang-(1-7) receptor Mas exert beneficial actions in various peripheral cardiovascular diseases, largely through opposition deleterious effects angiotensin II via its type 1 receptor. Here we considered possibility that may against CNS damage neurological deficits produced by cerebral ischaemic stroke. We determined central administration or pharmacological activation ACE2 on...
<h3>Importance</h3> Cerebral amyloid angiopathy–related inflammation (CAA-ri), a distinct subtype of cerebral angiopathy, is characterized by an autoimmune reaction to cerebrovascular β-amyloid deposits. Outcomes and response immunosuppressive therapy for CAA-ri are poorly understood. <h3>Objective</h3> To identify clinical, neuroimaging, laboratory, pathologic, or treatment-related associations with outcomes after episode CAA-ri. <h3>Design, Setting, Participants</h3> A retrospective cohort...
Abstract Acute ischemic stroke affects men and women differently. In particular, are often reported to experience higher acute severity than men. We derived a low-dimensional representation of anatomical lesions designed Bayesian hierarchical modeling framework tailored estimate possible sex differences in lesion patterns linked (National Institute Health Stroke Scale). This was developed 555 patients (38% female). Findings were validated an independent cohort (n = 503, 41% Here, we show...
Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients distal medium vessel occlusions (DMVO) are not well understood.
Acute ischemic stroke (AIS) from primary medium vessel occlusions (MeVO) is a prevalent condition associated with substantial morbidity and mortality. Despite the common use of mechanical thrombectomy (MT) in AIS, predictors poor outcomes MeVO remain poorly characterized.
Background The combination of intravenous thrombolysis (IVT) with mechanical thrombectomy (MT) may have clinical benefits for patients medium vessel occlusion. Purpose To examine whether MT combined IVT is associated different outcomes than alone in acute ischemic stroke (AIS) and Materials Methods This retrospective study included consecutive adult AIS occlusion treated or at 37 academic centers North America, Asia, Europe. Data were collected from September 2017 to July 2021. Propensity...
When transferred from a referring hospital (RH) to thrombectomy-capable stroke center (TCSC), patients with initially favorable imaging profiles (Alberta Stroke Program Early CT Score [ASPECTS] ≥6) often demonstrate infarct progression significant enough make them ineligible for mechanical thrombectomy at arrival. In rapidly evolving care networks, the question of need vascular RHs remains unsolved, resulting in an important amount futile transfers thrombectomy.
Background and Purpose— For suspected large vessel occlusion patients efficient transfer to centers that provide endovascular therapy (ET) is critical maximizing treatment opportunity. Our objective was examine associations between time, modes of transfer, ET, outcomes within a hub-and-spoke telestroke network. Methods— Patients with ischemic stroke were included if transferred single hub hospital January 2011 October 2015 National Institutes Health Stroke Scale>6, onset<12 hours from...
Persons with pre-existing disabilities represent over one-third of acute stroke presentations, but account for a far smaller proportion those receiving endovascular thrombectomy (EVT) and thrombolysis. This is despite existing ethical, economic, legal, social directives to maximize equity this vulnerable population. We sought determine associations between baseline modified Rankin Scale (mRS) outcomes after EVT.Individuals who underwent EVT were identified from prospectively maintained...
Stroke is the second leading cause of death worldwide and a adult disability worldwide. More than third individuals presenting with strokes are estimated to have preexisting disability. Despite unprecedented advances in stroke research clinical practice over past decade, approaches acute care for persons received scant attention. Current standards influenced by an underexplored range biases that may hinder These trends exacerbate unequal health outcomes rendering novel therapies inaccessible...