Constantin Hecker
A5016158694- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Peripheral Artery Disease Management
- Meningioma and schwannoma management
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Pharmacological Effects and Toxicity Studies
- Cardiac Imaging and Diagnostics
- Vitamin C and Antioxidants Research
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- interferon and immune responses
- Peripheral Neuropathies and Disorders
- Moyamoya disease diagnosis and treatment
- Brain Tumor Detection and Classification
- Brain Metastases and Treatment
Paracelsus Medical University
2014-2025
Christian Doppler Klinik
2018-2024
Population Health Research Institute
2024
McMaster University
2024
Unfallkrankenhaus Salzburg
2021
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Acute ischemic stroke (AIS) caused by distal medium vessel occlusions (DMVOs) represents a significant proportion of overall cases. While intravenous thrombolysis (IVT) has been primary treatment, advancements in endovascular procedures have led to increased use mechanical thrombectomy (MT) DMVO patients. However, symptomatic intracerebral hemorrhage (sICH) remains critical complication AIS, particularly after undergoing intervention. This study aims identify factors associated with sICH patients MT.
Background The efficacy of endovascular treatment (EVT) in acute ischaemic stroke due to distal medium vessel occlusion (DMVO) remains uncertain. Our study aimed evaluate the safety and EVT compared with best medical management (BMM) DMVO. Methods In this prospectively collected, retrospectively reviewed, multicentre cohort study, we analysed data from Multicentre Analysis primary Distal occlusions: effect Mechanical Thrombectomy registry. Patients DMVO M2, M3 M4 segments who underwent or...
The development of intracranial hemorrhage (ICH) in acute ischemic stroke is associated with a higher neutrophil to lymphocyte ratio (NLR) peripheral blood. Here, we studied whether the predictive value NLR at admission also translates into occurrence hemorrhagic complications and poor functional outcome after endovascular treatment (EVT).We performed retrospective analysis consecutive patients anterior circulation who underwent EVT tertiary care center from 2012 2016. Follow-up scans were...
Background and Purpose: Endovascular therapy for tandem occlusion strokes of the anterior circulation is an effective safe treatment. The best treatment approach cervical internal carotid artery (ICA) lesion still unknown. In this study, we aimed to compare functional safety outcomes between different approaches ICA during endovascular acute ischemic due in current clinical practice. Methods: Individual patients’ data were pooled from French prospective multicenter observational ETIS...
Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients distal medium vessel occlusions (DMVO) are not well understood.
Acute ischemic stroke (AIS) from primary medium vessel occlusions (MeVO) is a prevalent condition associated with substantial morbidity and mortality. Despite the common use of mechanical thrombectomy (MT) in AIS, predictors poor outcomes MeVO remain poorly characterized.
Background and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed evaluate safety efficacy DMVO patients treated with either MT-IVT or alone.Methods multinational analyzed data from 37 centers across North America, Asia, Europe. Patients AIS were included, collected September 2017...
In patients with large ischemic stroke, thrombectomy within 12 hours after onset was superior to best medical treatment in reducing 90-day functional disability irrespective of the collateral status on single-phase CT angiography images.
Emergent carotid artery stenting plus mechanical thrombectomy is an effective treatment for acute ischemic stroke patients with tandem occlusion of the anterior circulation. However, there limited data supporting safety this approach in treated prior intravenous thrombolysis (IVT). We aimed to investigate emergent stenting-mechanical patient population IVT—We assessed because atherosclerotic that were from multicenter observational Thrombectomy Tandem Lesions registry. Patients divided into...
Background and Purpose— Antiplatelet agents could be used in the setting of endovascular therapy for tandem occlusions to reduce risk de novo intracranial embolic migration, reocclusion extracranial internal carotid artery lesion, or in-stent thrombosis case stent placement but have balanced with intracerebral hemorrhagic transformation risk. In this study, we aim investigate impact acute antiplatelet administration on outcomes during anterior circulation occlusions. Methods— This is a...
Introduction: First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is significant predictor favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional and predictors FPE medium occlusions (MeVO) are scarce. Patients Methods: We conducted an international retrospective study MeVO cases. Multivariable logistic modeling was used to establish independent FPE. Clinical...
OBJECTIVE The authors compared the Contour Neurovascular System (Contour) with Woven EndoBridge (WEB) device for treatment of wide-necked cerebral aneurysms at a bifurcation or sidewall. METHODS Prospective clinical and radiological data were collected all patients treated either WEB tertiary university hospital from May 2018 to June 2022. RESULTS In who had least 3 months follow-up available (median patient age 60.0 [IQR 51.8–67.0] years, male/female ratio 1:1.4), 40 in 34 30 WEB. Overall,...
Background Intrasaccular devices have become increasingly popular in the treatment of cerebral aneurysms, particularly at bifurcation. Here we evaluate Contour Neurovascular System, an intrasaccular device for endovascular a multicenter cohort study, largest to best our knowledge. Methods Consecutive patients with intracranial aneurysms treated System between February 2017 and October 2022 10 European neurovascular centers were prospectively collected retrospectively reviewed. Patient...
Background For acute proximal intracranial artery occlusions, contact aspiration may be more effective than stent‐retriever for first‐line reperfusion therapy. Due to the lack of data regarding medium vessel occlusion thrombectomy, we evaluated outcomes according technique in a large, multicenter registry. Methods Imaging, procedural, and clinical patients with occlusions (M2, A1, or P1) distal (M3, A2, P2, further) treated at 37 sites 10 countries were analyzed endovascular (stent‐retriever...
Exploratory analysis of the phase 2 PACIFIC-Stroke (Program Anticoagulation via Inhibition FXIa by Oral Compound BAY 2433334-Non-Cardioembolic Stroke) randomized trial suggested that asundexian, an oral factor XIa inhibitor, prevents recurrent stroke and transient ischemic attacks in patients with atherosclerotic stroke. In this post hoc exploratory analysis, we hypothesized asundexian would be more effective enrolled large, multiple, or cortical acute infarcts on magnetic resonance imaging...
This study evaluates the early clinical performance of new Artisse Intrasaccular Device (Artisse ISD), a self-expandable intrasaccular flow diverter, for treating wide-necked aneurysms (WNAs). We report initial safety and efficacy outcomes in first cohort patients treated with this novel device.
Background Current randomized controlled trials are investigating the efficacy and safety of mechanical thrombectomy (MT) in patients with medium vessel occlusion (MeVO) stroke. Whether best medical management (MM) is more efficient than unsuccessful recanalization during MT remains unknown. Methods This was a retrospective cohort study using data from 37 academic centers across North America, Asia, Europe between September 2017 July 2021. Only distal branches (M2 M3) middle cerebral artery...
Abstract Assessment of the potential impact epilepsy as primary tumor manifestation on survival in elderly glioblastoma multiforme (GBM) patients. Two academic neurosurgical centers retrospectively analyzed all GBM patients aged 65 years and older with de-novo tumors, who underwent surgery between 2006 2021. Epidemiological, histopathological, imaging data were obtained from patients’ electronic charts, screened for presence preoperatively during follow-up. Patient status was assessed by...
Mechanical thrombectomy (MT) is established as an effective treatment for large vessel occlusion strokes, but its efficacy and safety medium occlusions (MeVOs) remain less clear. This study examines the impact of periprocedural embolization to a new vascular territory (ENT) on clinical outcomes in patients with MeVO stroke treated MT. A multicenter, retrospective analysis was conducted using MAD-MT (Multicenter Analysis primary Distal occlusions: effect Thrombectomy) registry, including 2122...
Iatrogenic cerebral amyloid angiopathy (iCAA) is a recently identified clinico-neuroradiological syndrome associated with medical procedures, particularly neurosurgical treatments involving cadaveric dura mater (e.g., Lyodura). iCAA can manifest as intracerebral hemorrhages, focal seizures, and cognitive impairment, the risk following exposure currently unknown. We aim to evaluate of developing in patients who underwent childhood treatment Lyodura compared those did not. This retrospective...