François Zhu
A5054897620- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Peripheral Artery Disease Management
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Healthcare Systems and Practices
- Vascular Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Retinal and Optic Conditions
- COVID-19 Clinical Research Studies
- Shoulder and Clavicle Injuries
- Head and Neck Surgical Oncology
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Infectious Encephalopathies and Encephalitis
- Shoulder Injury and Treatment
- Spinal Hematomas and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Health, Medicine and Society
Imagerie Adaptative Diagnostique et Interventionnelle
2018-2025
Inserm
2019-2025
Infection et inflammation
2025
Centre Hospitalier Régional et Universitaire de Nancy
2017-2025
Université de Tours
2025
Centre Hospitalier de l’Université de Montréal
2025
Université de Lorraine
2018-2024
Northwestern Medicine
2024
Northwestern University
2024
Centre Hospitalier Universitaire de Rennes
2021-2023
Background Brain MRI parenchymal signal abnormalities have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Purpose To describe the neuroimaging findings (excluding ischemic infarcts) in patients disease 2019 (COVID-19) infection. Materials and Methods This was a retrospective study of evaluated from March 23, 2020, to April 27, at 16 hospitals. Inclusion criteria were (a) positive nasopharyngeal or lower tract reverse transcriptase polymerase chain reaction...
To describe neuroimaging findings and to report the epidemiologic clinical characteristics of patients with coronavirus disease 2019 (COVID-19) neurologic manifestations.In this retrospective multicenter study (11 hospitals), we included 64 confirmed COVID-19 manifestations who underwent a brain MRI.The cohort 43 men (67%) 21 women (33%); their median age was 66 (range 20-92) years. Thirty-six (56%) MRIs were considered abnormal, possibly related severe acute respiratory syndrome...
Background and Purpose: The efficiency of prehospital care chain response the adequacy hospital resources are challenged amid coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients ischemic stroke eligible mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection treated MT, ranging 45 days across epidemic containment measures instatement, during same calendar period in 2019. primary end point was variation receiving MT...
Decision making for preventive interventions in asymptomatic patients, such as the treatment of incidental intracranial aneurysms, is eminently uncertain and at risk over-treatment. One approach suggests that weighing natural disease against intervention should be replaced by a comparison outcomes measured expected quality-adjusted life-years survival. We review problems over-diagnosis over-treatment how prognostic studies can help address clinical uncertainty. examine compare assumptions...
Background and Purpose: Endovascular therapy for tandem occlusion strokes of the anterior circulation is an effective safe treatment. The best treatment approach cervical internal carotid artery (ICA) lesion still unknown. In this study, we aimed to compare functional safety outcomes between different approaches ICA during endovascular acute ischemic due in current clinical practice. Methods: Individual patients’ data were pooled from French prospective multicenter observational ETIS...
Emergent carotid artery stenting plus mechanical thrombectomy is an effective treatment for acute ischemic stroke patients with tandem occlusion of the anterior circulation. However, there limited data supporting safety this approach in treated prior intravenous thrombolysis (IVT). We aimed to investigate emergent stenting-mechanical patient population IVT—We assessed because atherosclerotic that were from multicenter observational Thrombectomy Tandem Lesions registry. Patients divided into...
Background and Purpose— Antiplatelet agents could be used in the setting of endovascular therapy for tandem occlusions to reduce risk de novo intracranial embolic migration, reocclusion extracranial internal carotid artery lesion, or in-stent thrombosis case stent placement but have balanced with intracerebral hemorrhagic transformation risk. In this study, we aim investigate impact acute antiplatelet administration on outcomes during anterior circulation occlusions. Methods— This is a...
Background and hypothesis There is no consensus on the optimal endovascular management of extracranial internal carotid artery steno-occlusive lesion in patients with acute ischemic stroke due to tandem occlusion. We hypothesized that intracranial mechanical thrombectomy plus emergent stenting (and at least one antiplatelet therapy) superior alone Study design TITAN an investigator-initiated, multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) study. Eligibility...
Background and Purpose: Although the efficacy of endovascular treatment (EVT) in patients with anterior circulation ischemic stroke (AIS) is well documented, early neurological deterioration after EVT remains a serious issue associated poor outcome. Besides obvious causes, such as lack reperfusion, procedural complications, or parenchymal hemorrhage, may remain unexplained (UnEND). Our aim was to investigate predictors UnEND AIS. Methods: Patients who underwent for AIS, an initial National...
Neurointerventionists lack guidelines for the use of antithrombotic therapies in their clinical practice; consequently, there is likely to be significant heterogeneity between centers. Through a nationwide survey, we aimed obtain an exhaustive cross-sectional overview neurointerventional procedures France.In April 2021, French surgery centers were invited participate 51-question survey disseminated through active trainee-led research collaborative network (the JENI-RC).All 40 answered...
Background and Purpose- Carotid artery stenting in tandem large vessel occlusion strokes is usually avoided because of the intracranial hemorrhagic risks induced by antiplatelet therapy during thrombectomy interventions. This study aimed to evaluate incidence transformation following patients with atherosclerotic cervical carotid occlusion, associated factors, clinical relevance. Methods- The TITAN (Thrombectomy Tandem Lesions) collaboration pooled individual data prospectively collected...
The efficacy of endovascular therapy in patients with acute ischemic stroke due to tandem occlusion is comparable that for isolated intracranial the anterior circulation. However, optimal management cervical internal carotid artery lesions unknown, especially setting dissection, but emergency stenting (CAS) frequently considered. We investigated safety and CAS dissection current clinical practice. retrospectively analyzed a prospectively maintained database composed 2 merged multicenter...
Background and Purpose Patients with acute ischemic stroke, proximal vessel occlusion a large core at presentation are commonly not considered for mechanical thrombectomy (MT). We tested the hypothesis that in patients baseline infarct cores, identification of remaining penumbral tissue using perfusion imaging would translate to better outcomes after MT.<br/>Methods This was multicenter, retrospective, lab adjudicated, cohort study adult occlusion, volume (diffusion weighted ≥70 mL),...
Background and purpose Asymptomatic intracranial hemorrhage (aICH) is a common occurrence after endovascular treatment (EVT) for acute ischemic stroke (AIS). The aims of this study were to address its impact on 3‐month functional outcome identify risk factors aICH EVT. Methods Patients with AIS attributable anterior circulation large vessel occlusion who underwent EVT enrolled in multicenter prospective registry. Based imaging performed 22–36 h post‐EVT, we included patients no (ICH) or...
The presence of a coincident intracranial aneurysm (CIA) on the target vessel patients undergoing mechanical thrombectomy (MT) for acute ischemic stroke (AIS) poses challenges, as benefits and risks procedure in this scenario remain unclear. This study aimed to evaluate efficacy safety MT AIS cases with CIA vessel. We retrospectively analyzed data from 14 centers France Switzerland between January 2015 2023. identified treated MT. control population was constituted ETIS registry...
Coronavirus disease 2019 (COVID-19) may affect various organs. This case series reports nine patients (one of [11%] women and eight [89%] men; mean age ± standard deviation, 56 years 13) with globe MRI abnormalities obtained from a multicenter cohort 129 presenting severe COVID-19 March 4, 2020, to May 1, 2020. Nine (7%) had one or several nodules the posterior pole that were hyperintense at fluid-attenuated inversion-recovery imaging. All in macular region, (89%) bilateral nodules, two...
Background: Management of extracranial internal carotid artery steno-occlusive lesion during endovascular therapy remains debated. Stent occlusion within 24 hours is a frequent event after acute stenting, and we currently lack large population results. We investigated the incidence, predictors, clinical impact stent stenting in current practice. Methods: Patients treated by with between 2015 2019 5 large-volume endovascular-capable centers were retrospectively analyzed. separated 2 groups...