A5057843713- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Heat shock proteins research
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Biomarkers in Disease Mechanisms
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
- Nutritional Studies and Diet
- Cardiovascular Issues in Pregnancy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Cerebral Venous Sinus Thrombosis
- Moyamoya disease diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Lipoproteins and Cardiovascular Health
- Cardiovascular Syncope and Autonomic Disorders
- Dysphagia Assessment and Management
Innsbruck Medical University
2016-2025
Universität Innsbruck
2016-2025
VASCage
2021-2025
University of Calgary
2009-2024
Foothills Medical Centre
2009-2024
Medical University of Vienna
2008-2023
Sigmund Freud University Vienna
2017-2023
St. John's Hospital
2023
Pulmonary Vascular Research Institute
2023
Medical University of Graz
2014-2023
Objectives— Although cadmium (Cd) is an important and common environmental pollutant has been linked to cardiovascular diseases, little known about its effects in initial stages of atherosclerosis. Methods Results— In the 195 young healthy women Atherosclerosis Risk Factors Female Youngsters (ARFY) study, level was independently associated with early atherosclerotic vessel wall thickening (intima-media thickness exceeding 90th percentile distribution; multivariable OR 1.6[1.1.–2.3], P...
<b>Objective: </b> To estimate rates, predictors, and prognostic importance of recanalization in an unselected series patients with stroke treated IV thrombolysis. <b>Methods: We performed a CT angiography or transcranial Doppler (TCD) follow-up examination 24 hours after thrombolysis 64 documented occlusion the intracranial internal carotid middle cerebral artery (MCA). Complete was defined by rating 3 on Thrombolysis Myocardial Infarction 4/5 Brain Ischemia grading scales. Information...
Background— Necropsy studies suggest that atherosclerosis begins in childhood, but vivo confirmation of this concept is sparse and limited to selected population samples. Furthermore, new risk concepts focusing on inflammation, infections, immunity have not yet been evaluated age group. Methods Results— This study was conducted a sample 141 17- 18-year-old white males homogenous sex. In addition classic factors, C-reactive protein the humoral cellular immune reactivity heat-shock proteins...
To analyze the association between patient age and good functional outcome after ischemic stroke with special focus on young patients who were numerically underrepresented in previous evaluations.Of 43,163 prospectively enrolled Austrian Stroke Unit Registry, 6,084 (14.1%) ≤55 years old. Functional was available a representative subsample of 14,256 free prestroke disability, 2,223 whom 55 or younger. Herein we analyzed effects 3 months (modified Rankin Scale score ≤2).Good achieved 88.2%...
The highly conserved and ubiquitous heat shock proteins (HSP) are essential for the cellular homeostasis efficiently trigger responses to stress conditions. Both microbial human HSP act as dominant antigens in numerous infectious autoimmune diseases such atherosclerosis, inducing a strong immune-inflammatory response. In present study, surface localization of HSP60 on stressed unstressed umbilical venous endothelial cells (HUVECs) was investigated using sensitive high resolution microscopy...
Background and Purpose- Several risk factors are known to increase mid- long-term mortality of ischemic stroke patients. Information on predictors early is scarce but often requested in clinical practice. We therefore aimed develop a rapidly applicable tool for predicting at the unit. Methods- used data from nationwide Austrian Stroke Unit Registry multivariate regularized logistic regression analysis identify demographic variables associated with (≤7 days poststroke) patients admitted...
Dysphagia is associated with poor outcome, higher mortality, reduced quality of life, and social isolation. We investigate the relationship between swallowing impairment symptoms anxiety depression after ischemic stroke.
Neuroglia critically shape the brain´s response to ischemic stroke. However, their phenotypic heterogeneity impedes a holistic understanding of cellular composition early lesion. Here we present single cell resolution transcriptomics dataset acute infarction. Oligodendrocyte lineage cells and astrocytes range among most transcriptionally perturbed populations exhibit infarction- subtype-specific molecular signatures. Specifically, find infarction restricted proliferating oligodendrocyte...
To identify factors that influence plasma levels and assess the prognostic value of lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in a prospective, population-based survey epidemiology pathogenesis atherosclerosis. The Bruneck study is initiated 1990. Lp-PLA2 baseline variables for current analysis were measured 765 subjects aged 45–84 years 1995. Incident cardiovascular disease (CVD) (cardiovascular death, myocardial infarction, stroke, transient ischaemic attack) rates non-CVD...
Background: Cadmium is a potential new risk factor for early atherosclerosis and cardiovascular diseases in humans, yet pathogenetic mechanisms are still matter of debate. Methods Results: In-depth histological analysis 18 sections taken from 6 cadmium-fed ApoE-/- mice 12 5 litter-mates not exposed to cadmium by light scanning electron microscopy was performed. Cadmium-fed showed marked increase lesion load (plaque area) severity as classified according the American Heart Association...
TIA is associated with a substantial short-term risk of stroke and thus increasingly recognized as an unstable condition necessitating full medical attention. Our study sought to assess the rate predictors for early deterioration after or minor in large nationwide survey among Austrian units.Of 29,287 patients prospectively enrolled Stroke Unit Registry (2003-2008), 8,291 presenting ischemic stroke, defined by NIH Scale (NIHSS) score <4, were included current evaluation. Worsening was...
Background and Purpose- Posterior circulation stroke (PCS) account for 20% of all ischemic strokes. There is limited evidence whether functional outcome PCS comparable to that anterior (ACS). We aimed analyze 3-month different in ACS. Methods- Patients with acute prospectively enrolled within the Austrian Stroke Unit Registry were stratified by infarct localization according Oxfordshire Community Project Classification. Propensity score matching was used control covariate imbalances match...
Prominent fibrinogen cleavage by recombinant tissue plasminogen activator and formation of degradation products with anticoagulant properties was proposed to amplify the risk thrombolysis-related bleeding complications, but supportive evidence mainly derived from studies on myocardial infarction.This study included 547 consecutive stroke patients treated activator, who underwent repeated assessment levels before 6 hours after thrombolysis. Symptomatic intracranial hemorrhages were...
Background and Purpose— Sex-related differences in quality of acute stroke care are an important concern with limited data available, specifically regarding unit (SU) setting. We used the prospective nationwide Austrian SU registry to address this issue. Methods— Our analysis covered 8-year time period (January 2005 December 2012) during which all patients transient ischemic attack or admitted 1 35 had been captured registry. These were analyzed for age-adjusted preclinical clinical...
Patients with ischaemic stroke or transient attack (TIA) are at high risk of recurrent and other cardiovascular diseases commonly suffer from reduced quality life. We aimed to determine whether the disease management programme STROKE-CARD can prevent improve life in these patients.In this pragmatic open-label two-centre randomised controlled trial blinded outcome assessment, we randomly assigned patients acute TIA (ABCD2 score ≥3) a 2:1 ratio receive care standard care. is by...
Background and Purpose- Frequencies of treatment with r-tPA (recombinant tissue-type plasminogen activator) are increasing over the past 15 years. However, published data on influence various demographic clinical factors as well estimates future trajectories limited. We evaluated time trends in patients acute stroke by analyzing 103 970 enrolled Austrian Stroke Unit Registry from 2006 to 2018, which 18 953 were treated r-tPA. Methods- Time r-tPA-treatment investigated predefined subgroups...
It is unclear whether IV thrombolysis (IVT) outperforms early dual antiplatelet therapy (DAPT) in the acute setting of mild ischemic stroke. The aim this study was to compare safety and efficacy IVT with that DAPT.
The objectives of this study were to develop age- and sex-specific reference percentiles for fat mass index (FMI) fat-free (FFMI) in adolescents aged 14 19 years determine differences overweight/obesity classification by FMI body (BMI). EVA4YOU is a single-center cross-sectional conducted western Austria. Cardiovascular risks including anthropometric measurements bioelectrical impedance analysis assessed (mean age 17 years). FFMI calculated as the ratio (FM) (FFM) square height compared...
<h3>Background</h3> Several diseases characterized by chronic inflammation and immune activation have been linked to enhanced risk for atherosclerosis. The potential association between allergies atherosclerosis, however, remains be defined. <h3>Methods</h3> common allergic (allergic rhinitis asthma) 5-year development progression of carotid atherosclerosis (Bruneck Study) high intima-media thickness in femoral arteries (Atherosclerosis Risk Factors Male Youngsters [ARMY] study) was...