A5026157924- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular and Diving-Related Complications
- Cardiovascular Health and Disease Prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and genetic disorders
- Oropharyngeal Anatomy and Pathologies
- Peripheral Artery Disease Management
- Advanced Neuroimaging Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Cerebral Venous Sinus Thrombosis
- Healthcare Systems and Practices
- Neurological Complications and Syndromes
- Lipoproteins and Cardiovascular Health
- Cardiovascular Syncope and Autonomic Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
Université Paris Cité
2015-2024
Inserm
2015-2024
Tufts Medical Center
2013-2024
FHU Neurovasc
2015-2024
Institut de Psychiatrie et Neurosciences de Paris
2013-2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2023
Centre Hospitalier Sainte-Anne
2011-2021
Délégation Paris 5
2012-2021
Sorbonne Paris Cité
2012-2021
The cause of ischemic stroke in younger adults is undefined as many 35 percent patients. We studied the prevalence patent foramen ovale detected by contrast echocardiography a population 60 under 55 years old with and normal cardiac examination. compared results those control group 100 was significantly higher patients (40 percent) than (10 percent, P less 0.001). Among stroke, 21 19 an identifiable their 40 15 no but risk factor for such mitral valve prolapse, migraine, or use contraceptive...
Carotid stenting is less invasive than endarterectomy, but it unclear whether as safe in patients with symptomatic carotid-artery stenosis.We conducted a multicenter, randomized, noninferiority trial to compare endarterectomy carotid stenosis of at least 60%. The primary end point was the incidence any stroke or death within 30 days after treatment.The stopped prematurely inclusion 527 for reasons both safety and futility. 30-day 3.9% (95% confidence interval [CI], 2.0 7.2) 9.6% CI, 6.4...
2D : two-dimensional 3D : three-dimensional ABI : ankle–brachial index ACAS : Asymptomatic Carotid Atherosclerosis Study ACCF : American College of Cardiology Foundation ACE : angiotensin-converting enzyme ACS : acute coronary syndrome ACST : Surgery Trial ALI : limb ischaemia ASTRAL : Angioplasty and Stenting for Renal Artery Lesions trial BASIL : Bypass versus in Severe Ischaemia the Leg BOA : Dutch Oral Anticoagulants or Aspirin CABG : artery bypass grafting CAD : disease CAPRIE :...
Patent foramen ovale and atrial septal aneurysm have been identified as potential risk factors for stroke, but information about their effect on the of recurrent stroke is limited. We studied risks cerebrovascular events associated with these cardiac abnormalities.A total 581 patients (age, 18 to 55 years) who had an ischemic unknown origin within preceding three months were consecutively enrolled at 30 neurology departments. All received aspirin (300 mg per day) secondary prevention.After...
Few data document current cardiovascular (CV) event rates in stable patients with atherothrombosis a community setting. Differential for documented coronary artery disease (CAD), cerebrovascular (CVD), or peripheral arterial (PAD) those at risk of these diseases have not been previously evaluated single international cohort.To establish contemporary, international, 1-year CV outpatients established multiple factors atherothrombosis.The Reduction Atherothrombosis Continued Health (REACH)...
Trials of patent foramen ovale (PFO) closure to prevent recurrent stroke have been inconclusive. We investigated whether patients with cryptogenic and echocardiographic features representing risk would benefit from PFO or anticoagulation, as compared antiplatelet therapy.In a multicenter, randomized, open-label trial, we assigned, in 1:1:1 ratio, 16 60 years age who had recent attributed PFO, an associated atrial septal aneurysm large interatrial shunt, transcatheter plus long-term therapy...
An association between atrial septal aneurysm and embolic events has been suggested. Atrial shown to be associated with patent foramen ovale and, in some reports, mitral valve prolapse. These two latter cardiac disorders have identified as potential risk factors for ischemic stroke. The aim of this prospective study was assess the role an independent factor stroke, especially cryptogenic We studied prevalence aneurysm, ovale, prolapse 100 consecutive patients < 55 years age stroke who...
We aimed to create an index stratify cryptogenic stroke (CS) patients with patent foramen ovale (PFO) by their likelihood that the was related PFO.Using data from 12 component studies, we used generalized linear mixed models predict presence of PFO among CS, and derive a simple CS. estimated stratum-specific PFO-attributable fraction stroke/TIA recurrence rates.Variables associated in CS included younger age, cortical on neuroimaging, absence these factors: diabetes, hypertension, smoking,...
Background and Purpose — Patent foramen ovale (PFO) has been identified as a potential risk factor for stroke, but the mechanisms of PFO-associated stroke remain unsettled. The aim our study was to evaluate possible differences in factors patterns between patients with without PFO that may give clues mechanism stroke. Methods This prospective, multicentric involved 581 young cryptogenic patients. presence atrial septal aneurysm assessed by transesophageal echocardiography reviewed...
The incidence, causes, and prognosis of nonhemorrhagic strokes intraparenchymal hemorrhages occurring in association with pregnancy or puerperium are poorly understood.We carried out a retrospective (1989 through 1991) prospective (1992) study 63 public maternities (348,295 deliveries) the region Ile de France (10,660,554 inhabitants) neurology, neurosurgery, intensive care units same geographic area. Records women who suffered cerebrovascular event during first 2 weeks postpartum were...
It remains debated whether clinical scores can help identify acute ischemic stroke patients with large-artery occlusion and hence improve triage in the era of thrombectomy. We aimed to determine accuracy published predict occlusion.We assessed performance 13 consecutive undergoing examination magnetic resonance or computed tomographic angiography ≤6 hours symptom onset. When no cutoff was published, we used maximizing sum sensitivity specificity our cohort. also determined, for each score,...
<h3>Importance</h3> Recent epidemiologic and therapeutic advances have transformed understanding of the role approach to patent foramen ovale (PFO) in ischemic stroke. Patent is likely responsible for approximately 5% all strokes 10% those occurring young middle-aged adults. <h3>Observations</h3> Randomized clinical trials demonstrated that, prevent recurrent stroke patients with PFO an otherwise-cryptogenic index stroke, closure superior antiplatelet medical therapy alone; these provided...
Patent foramen ovale (PFO)-associated strokes comprise approximately 10% of ischemic in adults aged 18 to 60 years. While device closure decreases stroke recurrence risk overall, the best treatment for any individual is often unclear.To evaluate heterogeneity effect PFO on based previously developed scoring systems.Investigators Systematic, Collaborative, Closure Evaluation (SCOPE) Consortium pooled patient data from all 6 randomized clinical trials that compared plus medical therapy vs...
<h3>Importance</h3> The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (END<sub>i</sub>) following intravenous thrombolysis (IVT) this population may help to select candidates for immediate transfer additional thrombectomy. <h3>Objective</h3> To develop validate an easily applicable predictive score END<sub>i</sub>following IVT LVO. <h3>Design,...
Botulinum toxin type A is a potent neuromuscular paralyzing agent used in various disorders including cervical dystonia. Two preparations of botulinum are now commercially available ( Dysport and Botox), but much controversy remains about their respective potencies. The aim the study was to compare efficacy Botox with two different ratios Dysport.A double blind, randomised, three period cross over involving 54 patients dystonia performed. received following treatments randomised order: at...
A patent foramen ovale has been reported to be significantly more frequent in young stroke patients than matched control subjects, and paradoxical embolism suggested as the main mechanism of this situation. The present study was designed test hypothesis.Sixty-eight consecutive under 55 years age presenting with an ischemic had extensive workup, including transesophageal echocardiography contrast. We compared prevalence criteria for diagnosis without a ovale.A found 32 (47%)....