Charlotte Rosso
A5071631063- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Neurobiology of Language and Bilingualism
- Traumatic Brain Injury and Neurovascular Disturbances
- Transcranial Magnetic Stimulation Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Long-Term Effects of COVID-19
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Cerebral Venous Sinus Thrombosis
- Dementia and Cognitive Impairment Research
- Cerebral Palsy and Movement Disorders
- Spatial Neglect and Hemispheric Dysfunction
- Bone and Joint Diseases
- Multisensory perception and integration
- MRI in cancer diagnosis
- Neurosurgical Procedures and Complications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Medical Image Segmentation Techniques
- EEG and Brain-Computer Interfaces
Pitié-Salpêtrière Hospital
2016-2025
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2016-2025
Institut du Cerveau
2016-2025
Centre National de la Recherche Scientifique
2016-2025
FHU Neurovasc
2025
Population Health Research Institute
2024
McMaster University
2018-2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
The most difficult clinical questions in stroke rehabilitation are "What is this patient's potential for recovery?" and the best strategy person, given her/his profile?" Without answers to these questions, clinicians struggle make decisions regarding content focus of therapy, researchers design studies that inadvertently mix participants who have a high likelihood responding with those do not. Developing implementing biomarkers distinguish patient subgroups will help address issues unravel...
Patients with brain lesions provide a unique opportunity to understand the functioning of human mind. However, even when focal, have local and remote effects that impact functionally structurally connected circuits. Similarly, function emerges from interaction between areas rather than their sole activity. For instance, category fluency requires associations executive, semantic, language production functions.Here, we provide, for first time, set complementary solutions measuring given lesion...
Background This study provides a detailed imaging assessment in large series of patients infected with coronavirus disease 2019 (COVID-19) and presenting neurologic manifestations. Purpose To review the MRI findings associated acute manifestations COVID-19. Materials Methods was cross-sectional conducted between March 23 May 7, 2020, at Pitié-Salpêtrière Hospital, reference center for COVID-19 Paris area. Adult were included if they had diagnosis severe respiratory syndrome 2 (SARS-CoV-2)...
Little is known about the neuronal substrates of neuropsychiatric symptoms associated with COVID-19 and their evolution during course disease. We aimed at describing longitudinal brain metabolic pattern in COVID-19-related encephalopathy using 18F-FDG-PET/CT.Seven patients variable clinical presentations were explored thrice 18F-FDG-PET/CT, once acute phase, 1 month later 6 months after onset. PET images analysed voxel-wise regions-of-interest approaches comparison 32 healthy...
<h3>Importance</h3> Mechanical thrombectomy using a stent retriever or contact aspiration is widely used for treatment of patients with acute ischemic stroke due to anterior circulation large vessel occlusion, but the additional benefit combining uncertain. <h3>Objective</h3> To determine whether mechanical occlusion initial and combined results in better final angiographic outcome than standard alone. <h3>Design, Setting, Participants</h3> This trial was multicenter randomized, open-label,...
<h3>Importance</h3> The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (END<sub>i</sub>) following intravenous thrombolysis (IVT) this population may help to select candidates for immediate transfer additional thrombectomy. <h3>Objective</h3> To develop validate an easily applicable predictive score END<sub>i</sub>following IVT LVO. <h3>Design,...
Background and Purpose— The aim of the study was to evaluate whether leukoaraiosis (LA) is a risk factor for symptomatic intracerebral hemorrhage (sICH) in patients treated with thrombolysis acute stroke. Methods— In this retrospective, multicenter analysis, we evaluated data from anterior circulation stroke (n=449; <6 hours after symptom onset) thrombolysis. All had received standard magnetic resonance imaging evaluation before thrombolysis, including high-quality T2-weighted sequence....
Abstract Objective The risk for symptomatic intracerebral hemorrhage (sICH) associated with thrombolytic treatment has not been evaluated in large studies using diffusion‐weighted imaging (DWI). Here, we investigated the relation between pretreatment DWI lesion size and sICH after thrombolysis. Methods In this retrospective multicenter study, prospectively collected data from 645 patients anterior circulation stroke treated intravenous or intraarterial thrombolysis within 6 hours (<3...
Background and Purpose— Intensive insulin therapy (IIT) has not yet proven its efficacy on stroke prognosis or in the reduction of MRI infarct growth. The INSULINFARCT study aims at determining patients with hyperacute whether IIT, a better control poststroke hyperglycemia, would reduce subsequent growth than usual care subcutaneous insulin. Methods— One hundred eighty MRI-proven ischemic National Institutes Health Stroke Scale from 5 to 25 admission (<6 hours) were randomized receive IIT...
à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement et recherche français étrangers, laboratoires publics privés.
<h3>Importance</h3> Treatment with remote ischemic perconditioning has been reported to reduce brain infarction volume in animal models of stroke. Whether this neuroprotective effect was observed patients acute stroke remains unknown. <h3>Objective</h3> To determine whether treatment administered the leg can growth. <h3>Design, Setting, and Participants</h3> This proof-of-concept multicenter prospective randomized open-label blinded end point clinical trial performed from January 12, 2015,...
Stroke patients vary considerably in terms of outcomes: some present 'natural' recovery proportional to their initial impairment (fitters), while others do not (non-fitters). Thus, a key challenge stroke rehabilitation is identify individual potential make personalized decisions for neuro-rehabilitation, obviating the 'one-size-fits-all' approach. This goal requires (i) prediction courses acute stage; and (ii) an understanding underlying neuronal network mechanisms. 'Natural' especially...
Whether endovascular therapy (EVT) added on best medical management (BMM), as compared to BMM alone, is beneficial in acute ischemic stroke with isolated posterior cerebral artery occlusion unknown.We conducted a multicenter international observational study of consecutive patients admitted within 6 hours from symptoms onset 26 centers the first (P1) or second (P2) segment and treated either BMM+EVT alone. Propensity score inverse probability treatment weighting was used account for baseline...
SEE BURGESS DOI101093/BRAIN/AWW092 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE : Analogical reasoning is at the core of generalization and abstraction processes that enable concept formation creativity. The impact neurological diseases on analogical poorly known, despite its importance in everyday life society. Neuroimaging studies healthy subjects few have been performed patients highlighted prefrontal cortex reasoning. However, critical cerebral bases for deficits remain elusive. In...
<h3>Importance</h3> There is evidence of central nervous system impairments associated with coronavirus disease 2019 (COVID-19) infection, including encephalopathy. Multimodal monitoring patients COVID-19 may delineate the specific features COVID-19–related encephalopathy and guide clinical management. <h3>Objectives</h3> To investigate clinical, biological, brain magnetic resonance imaging (MRI) findings in association electroencephalographic (EEG) for COVID-19, to better refine <h3>Design,...
BackgroundMotor outcome after stroke is associated with reorganisation of cortical networks and corticospinal tract (CST) integrity. However, the relationships between motor severity, CST damage, functional brain connectivity are not well understood. Here, main objective was to study effect damage on relationship network hand function in two groups patients: severely (n=8) mildly impaired (n=14). MethodsTwenty-two carotid patients deficits were studied magnetic resonance imaging (MRI) at 3...
Combinatorial syntax has been shown to be underpinned by cortical key regions such as Broca's area and temporal cortices, subcortical structures the striatum. The are connected via several cortico-to-cortical tracts impacting syntactic processing (e.g., arcuate) but it remains unclear whether how striatum can integrated into this cortex-centered network. Here, we used a systematic stepwise approach investigate existence function of an additional deep Broca-striatum pathway. We first asked 15...
Background and Purpose- The TST trial (Treat Stroke to Target) evaluated the benefit of targeting a LDL (low-density lipoprotein) cholesterol <70 mg/dL reduce risk cardiovascular events in 2860 patients with ischemic stroke atherosclerotic stenosis cerebral vasculature or aortic arch plaque >4 mm, French Korean population. follow-up lasted median 5.3 years (similar time SPARCL [Stroke Prevention by Aggressive Reduction Cholesterol Level]) 2.0 patients. Exposure duration statin is well-known...
Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated incidence, risk factors, and clinical implications daily practice.We used data from ongoing prospective multicenter observational Endovascular Treatment Ischemic Stroke Registry France. The present study is a retrospective analysis 4029 stroke patients with treated between January 2015 May 2020 18 centers. systematically collected procedural data, incidence...