A5012310214- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Vestibular and auditory disorders
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Hemispheric Asymmetry in Neuroscience
- Mind wandering and attention
- Anesthesia and Neurotoxicity Research
- Photoreceptor and optogenetics research
- Pain Management and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Heart Rate Variability and Autonomic Control
- Acute Ischemic Stroke Management
- Identity, Memory, and Therapy
- Neuroscience, Education and Cognitive Function
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural and Behavioral Psychology Studies
- Visual perception and processing mechanisms
- Botulinum Toxin and Related Neurological Disorders
École Polytechnique Fédérale de Lausanne
2021-2025
Clinique Romande de Réadaptation
2021-2025
Wyss Center for Bio and Neuroengineering
2021-2022
The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference (tTIS) is a novel, noninvasive technology that might overcome this limitation. initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here we show successful neuromodulation the striatum via tTIS in humans using computational functional magnetic resonance imaging studies behavioral evaluations. Theta-burst...
Abstract Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, causal contribution of specific patterns oscillatory activity within human striatum is unknown. To address this question, we exploited a recently developed non-invasive deep stimulation technique called transcranial temporal interference (tTIS) during reinforcement learning with concurrent neuroimaging, in randomized, sham-controlled, double-blind study....
Stroke patients vary considerably in terms of outcomes: some present 'natural' recovery proportional to their initial impairment (fitters), while others do not (non-fitters). Thus, a key challenge stroke rehabilitation is identify individual potential make personalized decisions for neuro-rehabilitation, obviating the 'one-size-fits-all' approach. This goal requires (i) prediction courses acute stage; and (ii) an understanding underlying neuronal network mechanisms. 'Natural' especially...
. Selective neuromodulation of deep brain regions has for a long time only been possible through invasive approaches, because the steep depth-focality trade-off conventional non-invasive stimulation (NIBS) techniques.
Abstract Homonymous Hemianopia (HH), a common visual impairment resulting from occipital lobe lesions, affects significant number of stroke survivors. Intensive perceptual training can foster recovery, possibly by enhancing surviving pathways. This study employed cortico-cortical paired associative stimulation (ccPAS) to induce plasticity within the residual and bi-directional primary cortex (V1) - middle temporal area (MT) pathways in patients. We used ccPAS, which is thought tap into...
Abstract Objective: Non-invasive brain stimulation (NIBS) offers therapeutic benefits for various disorders. Personalization may enhance these by optimizing parameters individual subjects. Approach: We present a computational pipeline simulating and assessing the effects of NIBS using personalized, large-scale network activity models. Using structural MRI diffusion-weighted imaging data, leverages convolutional neural network-based segmentation algorithm to generate subject-specific head...
Episodic autobiographical memory (EAM) is a building block of self-consciousness, involving recollection and subjective re-experiencing personal past experiences. Any life episode originally encoded by subject within body. This raises the possibility that encoding shaped bodily self-consciousness (BSC), basic form arising from multisensory sensorimotor perceptual signals Recent studies in healthy subjects showed embodied improves EAM, with involvement hippocampus. However, there are only few...
Because of the depth hippocampal-entorhinal complex (HC-EC) in brain, understanding its role spatial navigation via neuromodulation was limited humans. Here, we aimed to better elucidate this relationship healthy volunteers, using transcranial temporal interference electric stimulation (tTIS), a noninvasive technique allowing selectively neuromodulate deep brain structures. We applied tTIS right HC-EC either continuous or intermittent theta-burst patterns (cTBS iTBS), compared control...
Background and Purpose: Structural brain networks possess a few hubs, which are not only highly connected to the rest of but also each other. These form rich-club, play central role in global organization. To investigate whether concept rich-club sheds new light on poststroke recovery, we applied novel network-theoretical quantification lesions patients with stroke compared outcomes what lesion size alone would indicate. Methods: Whole-brain structural 73 ischemic were reconstructed using...
Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used transcranial magnetic stimulation (TMS)-electroencephalography coupling to study cortical reactivity and intracortical GABAergic inhibition, well their relationship residual motor function longitudinally patients with
Effective, patient-tailored rehabilitation to restore upper-limb motor function in severely impaired stroke patients is still missing. If suitably combined and administered a personalized fashion, neurotechnologies offer large potential assist rehabilitative therapies enhance individual treatment effects. AVANCER (clinicaltrials.gov NCT04448483) two-center proof-of-concept trial with an based cumulative longitudinal intervention design aiming at reducing impairment affected the help of...
Tractography enables identifying and evaluating the healthy diseased brain's white matter pathways from diffusion-weighted magnetic resonance imaging data. As previous evaluation studies have reported significant false-positive estimation biases, recent microstructure-informed tractography algorithms been introduced to improve trade-off between specificity sensitivity. However, a major limitation for characterizing performance of these techniques is lack ground truth brain In this study, we...
Abstract Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative protocols, accounting related brain network interactions also, may further enhance effect sizes. Here, we tested different targeting the cerebro-cerebellar loop. Forty young, healthy participants trained a fine skill with concurrent tDCS...
Despite recent improvements, complete motor recovery occurs in <15% of stroke patients. To improve the therapeutic outcomes, there is a strong need to tailor treatments each individual patient. However, lack knowledge concerning precise neuronal mechanisms underlying degree and course its differences, especially view brain network properties despite fact that it became more clear disorder. The TiMeS project longitudinal exploratory study aiming at characterizing phenotypes large,...
Abstract Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. Especially, causal contribution of specific patterns oscillatory activity within human striatum is unknown. To address this question, we exploited an innovative, non-invasive deep stimulation technique called transcranial Temporal Interference Stimulation (tTIS) during reinforcement learning with concurrent neuroimaging, in a randomised, sham-controlled, double-blind study....
Abstract Stimulation of deep brain areas can offer benefits against cognitive impairments associated with aging. So far, this was only possible via invasive methods accompanied by risks. Grossman et al. proposed a new noninvasive stimulation technique, transcranial temporal interference electric (tTIS), which be steered to target and modulate activity structures. Memory capacity depends on subcortical structures such as the hippocampus, hence, modulation hippocampal could benefit declining...
Abstract The stimulation of deep brain structures has thus far been possible only with invasive methods. Transcranial electrical temporal interference (tTIS) is a novel, noninvasive technology that might overcome this limitation. initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here, we show for the first time successful neuromodulation striatum via tTIS in humans using computational fMRI studies behavioral evaluations. Theta-burst patterned,...
Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in units, with normative values acquired a healthy population. This study focuses on multi-echo T2 relaxometry, qMRI technique that probes complex tissue microstructure differentiating compartment-specific relaxation times. However, estimation methods are still limited their noise....