A5017895327- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Motor Control and Adaptation
- Stroke Rehabilitation and Recovery
- Pain Management and Treatment
- Tactile and Sensory Interactions
- Muscle activation and electromyography studies
- Functional Brain Connectivity Studies
Imperial College London
2022-2023
UK Dementia Research Institute
2022-2023
University College London
2018
The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference (tTIS) is a novel, noninvasive technology that might overcome this limitation. initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here we show successful neuromodulation the striatum via tTIS in humans using computational functional magnetic resonance imaging studies behavioral evaluations. Theta-burst...
Neurostimulation applied from deep brain stimulation (DBS) electrodes is an effective therapeutic intervention in patients suffering intractable drug-resistant epilepsy when resective surgery contraindicated or failed. Inhibitory DBS to suppress seizures and associated epileptogenic biomarkers could be performed with high-frequency (HFS), typically between 100 165 Hz, various deep-seated targets, such as the Mesio-temporal lobe (MTL), which leads changes rhythms, specifically hippocampus....
BackgroundElectrical stimulation involving temporal interference of two different kHz frequency sinusoidal electric fields (temporal (TI)) enables non-invasive deep brain by creating an field that is amplitude modulated at the slow difference within neural range target region.ObjectiveHere, we investigate using square, rather sinusoidal, create pulse-width, but not amplitude, (pulse-width interference, (PWM-TI)).Methods/Results: We show, ex-vivo single-cell recordings and in-vivo calcium...
Abstract Stimulation of deep brain areas can offer benefits against cognitive impairments associated with aging. So far, this was only possible via invasive methods accompanied by risks. Grossman et al. proposed a new noninvasive stimulation technique, transcranial temporal interference electric (tTIS), which be steered to target and modulate activity structures. Memory capacity depends on subcortical structures such as the hippocampus, hence, modulation hippocampal could benefit declining...
Abstract The stimulation of deep brain structures has thus far been possible only with invasive methods. Transcranial electrical temporal interference (tTIS) is a novel, noninvasive technology that might overcome this limitation. initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here, we show for the first time successful neuromodulation striatum via tTIS in humans using computational fMRI studies behavioral evaluations. Theta-burst patterned,...
Interfaces that exploit biological signals or movements to control the operation of lower-dimensional systems external body are at frontier for augmenting human abilities, but also constitute a learning challenge their users. We developed and tested an unsupervised coadaptive algorithm changed mapping machine interface match natural movement distribution Users controlled cursor on computer monitor using arm shoulder motions captured by set inertial sensors in either three conditions: i)...
Abstract Neurostimulation applied from deep brain stimulation (DBS) electrodes is an effective therapeutic intervention in patients suffering intractable drug-resistant epilepsy when resective surgery contraindicated or failed. Inhibitory DBS to suppress seizures and associated epileptogenic biomarkers could be performed with high-frequency (HFS), typically between 100 –165Hz, various deep-seated targets such as for instance the Mesio-temporal lobe (MTL) which leads changes rhythms,...
Background: Electrical stimulation involving temporal interference of two different kHz frequency sinusoidal electric fields (temporal (TI)), enables non-invasive deep brain by creating an field that is amplitude modulated at the slow difference (within neural range) target region.Objective: Here we aimed to validate, and investigate mechanism of, a uses temporally interfering biphasic square waves create pulse-width, but not amplitude, (pulse-width interference, (PWM-TI)).Methods/Results:...