A5062628381- Neurobiology of Language and Bilingualism
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Spatial Neglect and Hemispheric Dysfunction
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Reading and Literacy Development
- Cerebrovascular and genetic disorders
- EEG and Brain-Computer Interfaces
- Linguistics and Discourse Analysis
- Parkinson's Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Language, Metaphor, and Cognition
- Cerebrovascular and Carotid Artery Diseases
- Amyotrophic Lateral Sclerosis Research
- Action Observation and Synchronization
- Advanced MRI Techniques and Applications
- Language Development and Disorders
- Psychology of Moral and Emotional Judgment
- Neurological Disorders and Treatments
- Neuroscience and Neural Engineering
Sorbonne Université
2016-2025
Pitié-Salpêtrière Hospital
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Inserm
2012-2022
Centre National de la Recherche Scientifique
2006-2022
Institut du Cerveau
2013-2022
Nia Association
2022
ID Genomics (United States)
2022
Université Sorbonne Nouvelle
2018-2021
Centre de Résonance Magnétique des Systèmes Biologiques
2021
Within primary progressive aphasia the logopenic variant remains less understood than two other main variants, namely semantic and non-fluent aphasia. This may be because of relatively small number explored patients lack investigations with a comprehensive three-level characterization cognitive, brain localization biological aspects. The aim present study was to decipher through multimodal approach large cohort 19 (age 66.5 ± 8.7 years, symptom duration 3.2 0.6 years) using detailed...
We present Clinica ( www.clinica.run ), an open-source software platform designed to make clinical neuroscience studies easier and more reproducible. aims for researchers (i) spend less time on data management processing, (ii) perform reproducible evaluations of their methods, (iii) easily share results within institution with external collaborators. The core is a set automatic pipelines processing analysis multimodal neuroimaging (currently, T1-weighted MRI, diffusion PET data), as well...
The International Working Group recommended the Free and Cued Selective Reminding Test (FCSRT) as a sensitive detector of amnesic syndrome hippocampal type in typical Alzheimer's disease (AD). But does it differentiate AD from other neurodegenerative diseases?We assessed FCSRT cerebrospinal fluid (CSF) biomarkers 992 cases. Experts, blinded to biomarker data, attributed 650 cases diagnosis AD, frontotemporal dementia, posterior cortical atrophy, Lewy body disease, progressive supranuclear...
Objective Word finding depends on the processing of semantic and lexical information, it involves an intermediate level for mapping semantic-to-lexical information which also subserves lexical-to-semantic during word comprehension. However, brain regions implementing these components are still controversial have not been clarified via a comprehensive lesion model encompassing whole range language-related cortices. Primary progressive aphasia (PPA), anomia is thought to be most common sign,...
Noninvasive brain stimulation in primary progressive aphasia (PPA) is a promising approach. Yet, applied to single cases or insufficiently controlled small-cohort studies, it has not clarified its therapeutic value. We here address the effectiveness of transcranial direct current (tDCS) on semantic PPA variant (sv-PPA), applying rigorous study design large, homogeneous sv-PPA cohort.Using double-blind, sham-controlled counterbalanced cross-over design, we three tDCS conditions targeting...
Abstract Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated amyloid positivity is limited. Methods In 1640 SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations SCD‐specific (informant confirmation, domain‐specific complaints, concerns, feelings worse performance) demographics, setting, apolipoprotein E gene ( APOE ) ε4 carriership, and neuropsychiatric symptoms positivity. Results Between cohorts, in...
The role of the basal ganglia, and more specifically striatum, in language is still debated. Recent studies have proposed that linguistic abilities involve two distinct types processes: retrieving stored information, implicating temporal lobe areas, application combinatorial rules, fronto-striatal circuits. Studies patients with focal lesions neurodegenerative diseases suggested a for striatum morphological rule application, but functional imaging found left caudate was involved syntactic...
We describe the largest series of patients with TARDBP mutations presenting frontotemporal dementia (FTD) and review cases in literature to precisely characterize FTD diseases associated this genotype.The phenotypic characteristics 29 patients, including 10 new French Dutch 19 reviewed from literature, were evaluated.The most frequent phenotype was a behavioral variant (bvFTD), but significant proportion (40%) our had semantic (svFTD) or nonfluent variants (nfvFTD) at onset; svFTD...
Combinatorial syntax has been shown to be underpinned by cortical key regions such as Broca's area and temporal cortices, subcortical structures the striatum. The are connected via several cortico-to-cortical tracts impacting syntactic processing (e.g., arcuate) but it remains unclear whether how striatum can integrated into this cortex-centered network. Here, we used a systematic stepwise approach investigate existence function of an additional deep Broca-striatum pathway. We first asked 15...
To determine relative frequencies and linguistic profiles of primary progressive aphasia (PPA) variants associated with GRN (progranulin) mutations to study their neuroanatomic correlates.Patients PPA carrying (PPA-GRN) were selected among a national prospective research cohort 1,696 patients frontotemporal dementia, including 235 PPA. All amyloid-positive CSF biomarkers excluded. In this cross-sectional study, speech/language cognitive characterized standardized evaluations, gray matter...
Abstract On the assumption that linguistic faculties reflect both lexical storage in temporal cortex and combinatorial rules striatal circuits, several authors have shown striatal-damaged patients are impaired with conjugation while retaining knowledge of irregular verbs [Teichmann, M., Dupoux, E., Kouider, S., Brugières, P., Boissé, M. F., Baudic, Cesaro, Peschanski, & Bachoud-Lévi, A. C. (2005). The role striatum rule application. model Huntington's disease at early stage. Brain, 128,...
The role of sub-cortical structures in language processing, and more specifically the striatum, remains controversial. In line with psycholinguistic models stating that processing implies both recovery lexical information application combinatorial rules, striatum has been claimed to be involved either former component or latter. present study reconciles these conflicting views by showing striatum's involvement processes, depending on distinct striatal sub-regions. Using PET scanning a model...
Primary care is often the first point of contact for patients with cognitive complaints, making initial screening an essential step to avoid delays in diagnosing Alzheimer's disease (AD) at early stage. We developed MemScreen, a self-administered smartphone application that assesses overall cognition and verbal memory, evaluated its ability detect mild impairment (MCI) both general clinical populations. conducted two validation cohort studies: (1) UK-based Whitehall II study (13th wave,...
Abstract Introduction The corticobasal syndrome (CBS) constitutes a neurodegenerative disease spectrum with substantial phenotypical or biological heterogeneity, requiring large multimodal studies to identify its clinico‐biological signature while disentangling Alzheimer's (AD)‐related from non‐AD‐related CBS. Methods We analyzed (N = 45) monocenter expert‐clinic CBS cohort, recruited in motor and/or cognitive units avoid recruitment biases, assessed standardized cognitive‐language tests,...
Neuroimaging studies have described the brain alterations in primary progressive aphasia (PPA) variants (semantic, logopenic, nonfluent/agrammatic). However, few combined T1, FDG-PET and diffusion MRI techniques to study atrophy, hypometabolism tract across three PPA main variants. We therefore explored a large early-stage cohort of semantic, logopenic nonfluent/agrammatic (N = 86) 23 matched healthy controls with anatomical (cortical thickness), FDG PET (metabolism) (white matter tracts...