Sarah Evain
A5036004964- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Poisoning and overdose treatments
- Botulinum Toxin and Related Neurological Disorders
- Axon Guidance and Neuronal Signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac electrophysiology and arrhythmias
- Neurology and Historical Studies
- Peripheral Artery Disease Management
- Zebrafish Biomedical Research Applications
- Ion channel regulation and function
- Parkinson's Disease Mechanisms and Treatments
Centre hospitalier Bretagne Atlantique
2018-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
Neurology, Inc
2020
Inserm
2011
Institut de Transplantation Urologie en Nephrologie
2011
Nantes Université
2011
Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated incidence, risk factors, and clinical implications daily practice.We used data from ongoing prospective multicenter observational Endovascular Treatment Ischemic Stroke Registry France. The present study is a retrospective analysis 4029 stroke patients with treated between January 2015 May 2020 18 centers. systematically collected procedural data, incidence...
Background Studies have suggested that collateral status modifies the effect of successful reperfusion on functional outcome after endovascular therapy (EVT). We aimed to assess association between and EVT outcomes investigate whether modified outcomes. Methods used data from ongoing, prospective, multicenter Endovascular Treatment in Ischemic Stroke (ETIS) Registry. Collaterals were graded according American Society Interventional Therapeutic Neuroradiology/Society Radiology (ASITN/SIR)...
Background Endovascular treatment (EVT) for basilar artery occlusions (BAO) is associated with a higher rate of futile recanalization compared anterior circulation procedures. We aimed to identify the incidence and predictors poor clinical outcome despite successful reperfusion in current practice. Methods used data from ETIS (Endovascular Treatment Ischemic Stroke) registry, prospective multicenter observational registry stroke treated EVT France. Patients undergoing acute BAO January 2014...
Background The predictors of successful reperfusion and the effect after endovascular treatment (EVT) for M2 occlusions have not been well studied. We aimed to identify on outcomes EVT in current practice. Methods Patients with acute ischemic stroke due isolated who were enrolled prospective multicenter Endovascular Treatment Ischemic Stroke (ETIS) Registry France between January 2015 March 2020 included. primary outcome was a favorable outcome, defined as modified Rankin Scale (mRS) score...
The number of mechanical thrombectomy (MT) passes is strongly associated with angiographic reperfusion as well clinical outcomes in patients anterior circulation ischemic stroke. However, these associations have not been analyzed basilar artery occlusion (BAO). We investigated the influence MT on degree and outcomes, compared outcome after ≤3 versus >3 passes.We used data from prospective multicentric Endovascular Treatment Ischemic Stroke (ETIS) Registry at 18 sites France. Patients BAO...
Recent studies have highlighted the key role of immune protein CD3ζ in maturation neuronal circuits CNS. Yet, upstream signals that might recruit and activate neurons are still unknown. In this study, we show functions early development identify ephrinA1-dependent EphA4 receptor activation as an regulator CD3ζ. When newly born spherical, before neurite extension, found a transient aggregation at cell periphery matching initiation site future neurite. This accumulation correlated with...
<h3>BACKGROUND AND PURPOSE:</h3> The reasons for poor clinical outcome after thrombectomy acute stroke, concerning around half of all patients, are misunderstood. We developed a hierarchic algorithm based on DWI to better identify patients at high risk disability. <h3>MATERIALS METHODS:</h3> Our single-center, retrospective study included consecutive with ischemic stroke who underwent large anterior artery occlusion and pretreatment DWI. primary was the mRS 3 months onset. Multivariable...
The influence of prior antiplatelet therapy (APT) uses on the outcomes patients with acute ischemic stroke treated endovascular is unclear. We compared procedural and clinical in APT or not before onset.We analyzed 2 groups from ongoing prospective multicenter Endovascular Treatment Ischemic Stroke registry France: (APT+) without (APT-) by therapy, intravenous thrombolysis. Multilevel mixed-effects logistic models including center as random effect were used to compare angiographic (rates...
The Alberta Stroke Program Early CT scan Score (ASPECTS) is a reliable imaging biomarker of infarct extent on admission but the value 24-hour ASPECTS evolution in day-to-day practice not well studied, especially after successful reperfusion. We aimed to assess association between reperfusion with functional and safety outcomes, as identify predictors evolution.We used data from an ongoing prospective multicenter registry. patients anterior circulation large vessel occlusion treated...
It is unknown whether collateral status modifies the effect of pretreatment intravenous thrombolysis (IVT) on outcomes patients with large vessel occlusions treated endovascular therapy (EVT). We aimed to assess IVT EVT in clinical practice.We used data from ongoing prospective multicentric Endovascular Treatment Ischemic Stroke (ETIS) Registry France. Patients anterior circulation proximal within 6 hours symptom onset were enrolled. divided into two groups based IVT. The matched baseline...
A 63-year-old woman was referred for visuospatial difficulties. The clinical and neuropsychological examination in association with imaging biomarkers led to a diagnosis of posterior cortical atrophy (PCA). patient, an amateur watercolor artist, continued paint throughout her disease paintings illustrate original way the progression disorders. At advanced stage, evolution neurovisual disorders is difficult evaluate patients. While studies have shown changes artistic style neurodegenerative...
Background: Alberta Stroke Program Early CT scan Score (ASPECTS) is a reliable imaging biomarker of infarct extension in patients with large vessel occlusions. ASPECTS evolution, surrogate expansion, an important predictor functional and safety outcomes after endovascular therapy (EVT). In this study, we aimed to identify the predictors evolution successful reperfusion association between EVT. Methods: We used data from ongoing prospective multicenter Endovascular Treatment Ischemic (ETIS)...