Ludovic Lucas
A5081844614- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Complications and Syndromes
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Peripheral Artery Disease Management
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Trauma and Emergency Care Studies
- Retinal and Optic Conditions
- Long-Term Effects of COVID-19
- Cerebral Venous Sinus Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related cognitive impairment studies
- Congenital Heart Disease Studies
- Migraine and Headache Studies
- Blood Coagulation and Thrombosis Mechanisms
- Child Nutrition and Feeding Issues
- Pharmacological Effects and Toxicity Studies
- Dementia and Cognitive Impairment Research
- Clinical Nutrition and Gastroenterology
- Cardiovascular Health and Disease Prevention
Bordeaux Population Health
2021-2024
Centre Hospitalier Universitaire de Bordeaux
2020-2022
Fondation de Rothschild
2020-2022
Hôpital Pellegrin
2017-2022
Université Paris Cité
2022
Laboratoire de Recherche Vasculaire Translationnelle
2022
Université Sorbonne Paris Nord
2022
Sorbonne Université
2022
Inserm
2020-2022
Université de Bordeaux
2017-2021
Background and Purpose: The efficiency of prehospital care chain response the adequacy hospital resources are challenged amid coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients ischemic stroke eligible mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection treated MT, ranging 45 days across epidemic containment measures instatement, during same calendar period in 2019. primary end point was variation receiving MT...
<h3>Importance</h3> The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (END<sub>i</sub>) following intravenous thrombolysis (IVT) this population may help to select candidates for immediate transfer additional thrombectomy. <h3>Objective</h3> To develop validate an easily applicable predictive score END<sub>i</sub>following IVT LVO. <h3>Design,...
Background and Purpose: Mechanical thrombectomy (MT) is the recommended treatment for acute ischemic stroke caused by anterior circulation large vessel occlusion. However, despite a high rate of reperfusion, clinical response to successful MT remains highly variable in early time window where optimal imaging selection criteria have not been established. We hypothesize that baseline perfusion profile may help forecast this setting. Methods: conducted prospective multicenter cohort study...
Whether bridging therapy (intravenous thrombolysis [IVT] followed by endovascular treatment) is superior to IVT alone in minor stroke with large vessel occlusion (LVO) unknown.Multicentric retrospective observational study including, intention-to-treat, consecutive IVT-treated strokes (National Institutes of Health Stroke Scale [NIHSS] ≤ 5) LVO, or without additional mechanical thrombectomy. Propensity-score (inverse probability treatment weighting) was used reduce baseline between-groups...
Background and Purpose— Nonagenarians represent a growing stroke population characterized by higher frailty. Although endovascular therapy (ET) is cornerstone of the management acute ischemic related to large vessel occlusion, benefit reperfusion among nonagenarians poorly documented. We aimed assess impact ET-related on functional outcome in this elderly population. Methods— A retrospective analysis clinical imaging data from all patients aged over 90 included ETIS (Endovascular Treatment...
Background and Purpose: Although the efficacy of endovascular treatment (EVT) in patients with anterior circulation ischemic stroke (AIS) is well documented, early neurological deterioration after EVT remains a serious issue associated poor outcome. Besides obvious causes, such as lack reperfusion, procedural complications, or parenchymal hemorrhage, may remain unexplained (UnEND). Our aim was to investigate predictors UnEND AIS. Methods: Patients who underwent for AIS, an initial National...
Importance The benefit of reperfusion therapies for acute ischemic stroke decreases over time. This decreasing is presumably due to the disappearance salvageable brain tissue (ie, penumbra). Objective To study association between onset-to-imaging time and penumbral volume in patients with a large vessel occlusion. Design, Setting, Participants A retrospective, multicenter, cross-sectional was conducted from January 1, 2015, June 30, 2022. limit selection bias, were selected (1) prospective...
The efficacy of endovascular therapy in patients with acute ischemic stroke due to tandem occlusion is comparable that for isolated intracranial the anterior circulation. However, optimal management cervical internal carotid artery lesions unknown, especially setting dissection, but emergency stenting (CAS) frequently considered. We investigated safety and CAS dissection current clinical practice. retrospectively analyzed a prospectively maintained database composed 2 merged multicenter...
Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated incidence, risk factors, and clinical implications daily practice.We used data from ongoing prospective multicenter observational Endovascular Treatment Ischemic Stroke Registry France. The present study is a retrospective analysis 4029 stroke patients with treated between January 2015 May 2020 18 centers. systematically collected procedural data, incidence...
Background and purpose Asymptomatic intracranial hemorrhage (aICH) is a common occurrence after endovascular treatment (EVT) for acute ischemic stroke (AIS). The aims of this study were to address its impact on 3‐month functional outcome identify risk factors aICH EVT. Methods Patients with AIS attributable anterior circulation large vessel occlusion who underwent EVT enrolled in multicenter prospective registry. Based imaging performed 22–36 h post‐EVT, we included patients no (ICH) or...
Background: Management of extracranial internal carotid artery steno-occlusive lesion during endovascular therapy remains debated. Stent occlusion within 24 hours is a frequent event after acute stenting, and we currently lack large population results. We investigated the incidence, predictors, clinical impact stent stenting in current practice. Methods: Patients treated by with between 2015 2019 5 large-volume endovascular-capable centers were retrospectively analyzed. separated 2 groups...
BACKGROUND: Carotid web is a rare and likely underrecognized cause of ischemic stroke, particularly in young patients. Given the high risk recurrence, diagnostic delays may have serious consequences. This study aimed to assess incidence impact delayed carotid diagnosis after first event. METHODS: We conducted retrospective analysis using data from French ongoing multicenter prospective CAROWEB (Carotid Web registry). included patients with first-ever stroke or transient attack anterior...
Background: Whether bridging therapy (intravenous thrombolysis [IVT] followed by mechanical thrombectomy) is superior to IVT alone in minor stroke with large vessel occlusion unknown. Perfusion imaging may identify subsets of occlusion–related patients distinct response therapy. Methods: We conducted a multicenter international observational study consecutive IVT-treated (National Institutes Health Stroke Scale score ≤5) who had an anterior circulation and perfusion performed before IVT,...
Identification of acute ischemic stroke (AIS) cause is crucial for guidance secondary prevention. Previous studies have yielded inconsistent results regarding possible correlations between AIS and thrombus composition, as assessed by semiquantitative histological analysis. Here, we performed a correlation analysis cellular composition content, using quantitative biochemical assays.Homogenates 250 patients with thrombi were prepared mechanical grinding. Platelet, red blood cell, leukocyte...
Patients with acute basilar artery occlusion (BAO) and low-to-moderate symptoms (National Institutes of Health Stroke Scale [NIHSS] < 10) are poorly represented in thrombectomy trials. Our objective is to compare best medical management (BMT) this population.
Background and Purpose: The best anesthetic management for mechanical thrombectomy of large vessel occlusion strokes is still uncertain could impact the quality reperfusion clinical outcome. We aimed to compare efficacy safety outcomes between local anesthesia (LA) conscious sedation in a cohort acute ischemic stroke patients with anterior circulation treated current, everyday practice. Methods: Patients undergoing at 4 comprehensive centers France January 1, 2018, December 31, were pooled...
Mechanical thrombectomy (MT) is the standard of care for patients with anterior circulation large vessel occlusion. Early neurological improvement (ENI), defined as a reduction ≥ 8 on National Institutes Health Stroke Scale (NIHSS) compared baseline score, or an NIHSS score 0 1 at 24 h after MT, strong predictor 3-month favorable outcome in such patients. The impact ENI MT stroke basilar artery occlusion (BAO) not clear. We aimed to study effects BAO.We performed retrospective analysis...
<h3>BACKGROUND AND PURPOSE:</h3> The clinical differentiation between acute ischemic stroke and epileptic seizure may be challenging, making the correct diagnosis could avoid unnecessary reperfusion therapy. We examined accuracy of CTP in discriminating seizures from without identified arterial occlusion. <h3>MATERIALS METHODS:</h3> retrospectively consecutive patients our emergency department who underwent 4.5 hours following development an focal neurologic deficit were discharged with a...
Individualized patient selection for mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) and large core (LIC) at baseline is an unmet need. We tested the hypothesis that assessing functional relevance of both infarcted hypoperfused brain tissue would improve framework LIC MT.We performed a multicenter, retrospective study adults (ischemic volume >70 mL on MRI diffusion-weighted imaging) perfusion treated MT or best medical management (BMM). Primary outcome was 3-month...
In the settings of thrombectomy, first-pass effect (FPE), defined by a complete recanalization after one pass with no rescue therapy, has been shown to be associated an improved outcome. As this phenomenon predominantly described in anterior circulation strokes, we aimed study prevalence, outcomes, and predictors FPE patients basilar artery occlusion.From prospective multicentric registry, collected data all consecutive occlusion who underwent thrombectomy compared outcomes achieved those...