A5020462078- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Eosinophilic Disorders and Syndromes
- Blood Coagulation and Thrombosis Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Cardiac Arrest and Resuscitation
- Cerebral Venous Sinus Thrombosis
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Intramuscular injections and effects
- Chronic Myeloid Leukemia Treatments
- Cerebrospinal fluid and hydrocephalus
- Inflammatory Biomarkers in Disease Prognosis
- S100 Proteins and Annexins
- Hemoglobinopathies and Related Disorders
- Pregnancy and preeclampsia studies
- Cancer-related gene regulation
- Mast cells and histamine
- Renal Diseases and Glomerulopathies
Université Paris Cité
2018-2025
Inserm
2018-2025
Sorbonne Paris Cité
2018-2025
Optimisation Thérapeutique en Neuropsychopharmacologie
2024-2025
Laboratoire de Recherche Vasculaire Translationnelle
2018-2024
Université Sorbonne Paris Nord
2022-2024
Sorbonne Université
2016-2024
Assistance Publique – Hôpitaux de Paris
2018-2024
Hôpital Bichat-Claude-Bernard
2014-2024
Université Claude Bernard Lyon 1
2020-2024
Venous thrombo-embolic events (VTE) frequently occur in patients with pancreatic ductal adenocarcinoma (PDAC) and contribute to high morbidity mortality.To determine whether VTE biomarkers are related cancer, inflammation or precancerous states assess their relevance predict PDAC.We compared PDAC (n = 42), intraductal papillary mucinous neoplasm of the pancreas (IPMN, n 48) chronic pancreatitis 50). were followed-up for 6 months.Factor VIII, D-dimers, von Willebrand factor, free tissue...
Cerebral venous sinus thrombosis (CVST) is an uncommon thromboembolic event accounting for <1% of strokes resulting in brain parenchymal injuries. JAK2V617F mutation, the most frequent driving mutation myeloproliferative neoplasms, has been reported to be associated with worse clinical outcomes patients CVST. We investigated whether hematopoietic expression predisposes specific pathophysiological processes and/or prognosis after Using vivo mouse model CVST, we analyzed clinical, biological,...
Objective— Despite the high clinical relevance of thrombolysis, models for its study in human flowing blood are lacking. Our objective was to develop a microfluidic model comparative evaluation thrombolytic therapeutic strategies. Approach and Results— Citrated supplemented with 3,3′-dihexyloxacarbocyanine iodide Alexa Fluor 647 fibrinogen conjugate, recalcified, perfused 3 4 minutes at venous or arterial wall shear rate flow chambers coated collagen tissue factor generate nonocclusive...
Background Antiplatelet drugs represent potential candidates for protecting the penumbral microcirculation during cerebral ischemia and improving benefits of arterial recanalization in ischemic stroke. Yet while efficacy such adjuvant strategies has been shown to be highly time dependent, antiplatelet therapy at acute phase stroke cannot envisioned until diagnosis its nature have confirmed because presumed risk worsening bleeding case intracranial hemorrhage (ICH). Here, we investigated this...
<title>Abstract</title> The vascular system regulates brain clearance through arterial blood flow and lymphatic drainage of cerebrospinal fluid (CSF). Idiopathic intracranial hypertension (IIH), characterized by elevated pressure dural venous sinus stenoses, can be treated restoring via stenting, suggesting a role for in clearance. Using magnetic resonance imaging (MRI) IIH patients healthy controls, we identified that stenoses were associated with impaired drainage, perivenous retention,...
Background. Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is frequent but its causes remain elusive. Several non-exclusive mechanisms have been proposed explain IVT failure, including failed delivery of tPA and inhibition activity. We investigated whether biologically relevant intrathrombus concentrations t-PA were achieved patients with LVO AIS, neutrophil extracellulaer traps (NETs) contributed failure. Methods. In this cohort...
We aimed to determine if elevations in serum neuron-specific enolase are associated with brain injury and outcomes adults who require venoarterial extracorporeal membrane oxygenation.Prospective observational study.Two ICUs of a university hospital, Paris, France.Consecutive adult patients treated oxygenation for refractory cardiogenic shock or in-hospital cardiac arrest.None.Serum sampled 1, 3, 7 days after cannulation was stored at -80°C concentrations were measured batches the end study....
Myeloproliferative neoplasms (MPN) are associated with an increased risk of arterial and venous thrombosis. Pegylated-interferon alpha (IFN) hydroxyurea (HU) commonly used to treat MPN, but their effect on hemostasis has not yet been studied. The aim our study was determine whether IFN HU impact the biological hemostatic profile MPN patients by studying markers endothelial, platelet, coagulation activation. A total 85 (50 polycythemia vera 35 essential thrombocythemia) were included: 28...
BackgroundCorrect diagnosis of the cause thrombocytopenia is crucial for appropriate management patients. Hyposialylation/desialylation (characterized by abnormally high β‐galactose exposure) accelerates platelet clearance and can lead to thrombocytopenia. However, reference range exposure in healthy individuals has not been defined previously.ObjectiveThe objective present study was develop a standardized assay implementation clinical laboratory.Methodsβ‐Galactose measured platelet‐rich...
Laboratory confirmation of heparin-induced thrombocytopenia (HIT) is crucial importance and remains challenging relies on platelet functional assays highlighting the presence heparin-dependent platelet-activating antibodies in patient serum or plasma. Platelet using washed platelets include 14 C-serotonin release assay (SRA), usually described as gold standard, activation (HIPA). Since its first comparison with SRA there has been no additional published study regarding HIPA diagnostic...
More than 40% of endovascular therapy (EVT) fail to achieve complete reperfusion the territory occluded artery in patients with acute ischemic stroke (AIS). Understanding factors influencing EVT could help overcome its limitations. Our objective was study impact thrombus cell composition on procedures, using a simulation system for modeling thrombus-induced large vessel occlusion (LVO) flow conditions. In an open comparative trial, we analyzed behavior size-standardized platelet-rich and red...
Abstract Background Ligneous conjunctivitis (LC) is a rare disorder associated with plasminogen deficiency characterized by chronic fibrin deposits in the eyelids. All patients do not develop LC, whose underlying mechanisms remain unknown. Objective We investigated whether fibrinolytic activity was correlated phenotype and/or genotype suffering from LC and their relatives. Methods Plasminogen activity/antigen levels PLG mutations were determined 10 17 of asymptomatic relatives, healthy...
Bone marrow smear showing histiocytes (black arrow) containing sea blue granules stained with May-Grünwald Giemsa. A 70-old-year man on long-term parenteral nutrition (PN), extensive short-bowel intestinal resection, was referred for investigation of pancytopenia. Peripheral blood examination revealed non-regenerative normocytic anemia (8.2 g/dL), thrombocytopenia (100 × 109/L), leukopenia (3.2 109/L) without absolute neutropenia (1.9 and normal smear. Vitamin B12, folate, copper...
Abstract The vascular system regulates brain clearance through arterial blood flow and lymphatic drainage of cerebrospinal fluid (CSF). Idiopathic intracranial hypertension (IIH), characterized by elevated pressure dural venous sinus stenoses, can be treated restoring via stenting, suggesting a role for in clearance. Using magnetic resonance imaging (MRI) IIH patients healthy controls, we identified that stenoses were associated with impaired drainage, perivenous retention, accumulation. To...
Abstract Therapeutic plasma exchange (TPE) has been proposed to remove heparin-induced thrombocytopenia (HIT) antibodies before planned thoracic surgery in patients with acute HIT and allow brief re-exposure heparin during surgery. In on extracorporeal membrane oxygenation (ECMO), simultaneous administration of TPE alternative nonheparin anticoagulant therapies is challenging. We report 2 ECMO who underwent repeated enable cardiothoracic the use heparin. both cases, serial monitoring...