Oguzhan Coskun
A5062395190- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Advanced MRI Techniques and Applications
- Aortic Disease and Treatment Approaches
- Intracerebral and Subarachnoid Hemorrhage Research
- Infective Endocarditis Diagnosis and Management
- Peripheral Artery Disease Management
- Spinal Fractures and Fixation Techniques
- Retinal and Optic Conditions
- Cerebrospinal fluid and hydrocephalus
- MRI in cancer diagnosis
- Cerebral Venous Sinus Thrombosis
- Vascular Anomalies and Treatments
- Peripheral Nerve Disorders
- Moyamoya disease diagnosis and treatment
- Cardiovascular Health and Disease Prevention
- Fetal and Pediatric Neurological Disorders
- Neurofibromatosis and Schwannoma Cases
Namık Kemal University
2024
Hôpital Foch
2014-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
Université de Versailles Saint-Quentin-en-Yvelines
2015-2022
Fondation de Rothschild
2016-2022
ASTER
2021
Délégation Paris 7
2017
Inserm
2005-2017
Université Paris Cité
2017
Sorbonne Paris Cité
2017
The prevalence of white matter hyperintensities (WMHs) detected on cerebral MRI is associated with hypertension, but it not known whether blood pressure lowering can arrest their progression. We report here the results an substudy PROGRESS (Perindopril Protection Against Recurrent Stroke Study), a randomized trial in subjects cerebrovascular disease.The comprised 192 participants who had both at baseline and after mean follow-up time 36 months (SD=6.0 months). At first MRI, WMHs were graded...
Background and Purpose— Although successful reperfusion is usually defined as a modified Thrombolysis in Cerebral Infarction (mTICI) 2B or 3 at the end of procedure, studies have shown that mTICI patients had poorer functional outcomes than TICI patients. An 2C category has been recently introduced for with near-complete perfusion except slow flow few distal cortical vessels presence small emboli after mechanical thrombectomy. The purpose this study was to evaluate difference outcome between...
<h3>Importance</h3> Mechanical thrombectomy using a stent retriever or contact aspiration is widely used for treatment of patients with acute ischemic stroke due to anterior circulation large vessel occlusion, but the additional benefit combining uncertain. <h3>Objective</h3> To determine whether mechanical occlusion initial and combined results in better final angiographic outcome than standard alone. <h3>Design, Setting, Participants</h3> This trial was multicenter randomized, open-label,...
<h3>BACKGROUND AND PURPOSE:</h3> The TICI score is widely used to evaluate cerebral perfusion before and after the endovascular treatment of stroke. Recent studies showing effectiveness safety mechanical thrombectomy combine modified 2b 3 assess technical success treatment. purpose this study was determine how much clinical outcomes differ between patients achieving reperfusion. <h3>MATERIALS METHODS:</h3> We analyzed 222 consecutive with acute large intracranial artery occlusion anterior...
<h3>BACKGROUND AND PURPOSE:</h3> Mechanical thrombectomy with stent retrievers is now the standard therapy for selected patients ischemic stroke. The technique of A Direct Aspiration, First Pass Technique Endovascular Treatment Stroke (ADAPT) appears promising a high rate recanalization. We compared ADAPT versus (the Solitaire device) efficacy and safety as front-line endovascular procedure. <h3>MATERIALS METHODS:</h3> analyzed 243 consecutive large intracranial artery occlusions anterior...
In acute ischemic stroke patients, diffusion-weighted imaging (DWI)-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and an independent factor of functional outcome. Patients pretreatment DWI-ASPECTS ≤6 were excluded or under-represented in the recent randomized mechanical thrombectomy trials. Our aim was to assess impact reperfusion patients treated thrombectomy.We analyzed data collected between January 2012 August 2015 a bicentric...
Proximal large vessel occlusion (LVO) is present in up to 30% of minor strokes. The effectiveness mechanical thrombectomy (MT) the subgroup stroke with LVO anterior circulation still open debate. Data about MT this patients are sparse, and their optimal management has not yet been defined. purpose multicenter cohort study was evaluate experiencing acute ischemic (AIS) because circulation, presenting minor-to-mild symptoms (National Institutes Health Stroke Scale score <8).Multicenter...
Middle cerebral artery M2-segment occlusions represent an important subgroup of patients with acute stroke large-vessel occlusion. The safety mechanical thrombectomy, especially contact aspiration (CA), in such distal intracranial is still under debate. We compared reperfusion, adverse events, neurological recovery, and functional outcome isolated M2 according to the first-line strategy thrombectomy devices (CA versus stent retriever [SR]). This a post hoc analysis ASTER trial (Contact...
Background and Purpose: Endovascular therapy for tandem occlusion strokes of the anterior circulation is an effective safe treatment. The best treatment approach cervical internal carotid artery (ICA) lesion still unknown. In this study, we aimed to compare functional safety outcomes between different approaches ICA during endovascular acute ischemic due in current clinical practice. Methods: Individual patients’ data were pooled from French prospective multicenter observational ETIS...
Background and Purpose— Parenchymal hematoma (PH) is a rare but dreadful complication of acute ischemic stroke with unclear underlying mechanisms. We aimed to study the incidence predictors PH after mechanical thrombectomy. Methods— Data from prospective observational multicenter registry was screened identify patients an anterior circulation large vessel occlusion who underwent Clinical, imaging, procedural characteristics were used for analysis, including brain imaging systematically...
Background and Purpose: Although the efficacy of endovascular treatment (EVT) in patients with anterior circulation ischemic stroke (AIS) is well documented, early neurological deterioration after EVT remains a serious issue associated poor outcome. Besides obvious causes, such as lack reperfusion, procedural complications, or parenchymal hemorrhage, may remain unexplained (UnEND). Our aim was to investigate predictors UnEND AIS. Methods: Patients who underwent for AIS, an initial National...
Background and Purpose— Whether all acute stroke patients with large vessel occlusion need to undergo intravenous thrombolysis before mechanical thrombectomy (MT) is debated as (1) the incidence of post-thrombolysis early recanalization (ER) still unclear; (2) may be harmful in unlikely recanalize; and, conversely, (3) transfer for MT unnecessary highly likely recanalize. Here, we determined predictors ER referred derive prediction scores trial design. Methods— Registries from 4 MT-capable...
The efficacy of endovascular therapy in patients with acute ischemic stroke due to tandem occlusion is comparable that for isolated intracranial the anterior circulation. However, optimal management cervical internal carotid artery lesions unknown, especially setting dissection, but emergency stenting (CAS) frequently considered. We investigated safety and CAS dissection current clinical practice. retrospectively analyzed a prospectively maintained database composed 2 merged multicenter...
Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated incidence, risk factors, and clinical implications daily practice.We used data from ongoing prospective multicenter observational Endovascular Treatment Ischemic Stroke Registry France. The present study is a retrospective analysis 4029 stroke patients with treated between January 2015 May 2020 18 centers. systematically collected procedural data, incidence...
<b><i>Background:</i></b> In population-based studies, patients presenting with minor or mild stroke symptoms represent about two-thirds of patients, and almost one-third these are unable to ambulate independently at the time discharge. Although mechanical thrombectomy (MT) has become standard care for acute ischaemic proximal large vessel occlusion (LVO) in anterior circulation, management harbouring minor-to-mild not yet been determined by recent trials. The purpose...
Background The association between time to reperfusion and clinical outcome is well known in anterior circulation strokes, whereas the impact of main metrics remains unknown posterior strokes. We investigated effect different intervals from symptom onset on 90-day acute ischemic stroke patients with basilar artery occlusion, especially subset population presenting a low volume baseline diffusion-weighted imaging. Methods Results studied included prospective, multicenter, observational ETIS...
Background and purpose Asymptomatic intracranial hemorrhage (aICH) is a common occurrence after endovascular treatment (EVT) for acute ischemic stroke (AIS). The aims of this study were to address its impact on 3‐month functional outcome identify risk factors aICH EVT. Methods Patients with AIS attributable anterior circulation large vessel occlusion who underwent EVT enrolled in multicenter prospective registry. Based imaging performed 22–36 h post‐EVT, we included patients no (ICH) or...
Background Studies on the role of blood pressure ( BP ) variability specifically during mechanical thrombectomy MT are sparse and limited. Moreover, pulse PP has not been considered as a potent hemodynamic parameter to describe . We assessed impact functional outcome in acute ischemic stroke patients with large vessel occlusion Methods Results Acute presenting from January 2012 June 2016 were included. data prospectively collected ETIS (Endovascular Treatment Ischemic Stroke) registry....
Background: Management of extracranial internal carotid artery steno-occlusive lesion during endovascular therapy remains debated. Stent occlusion within 24 hours is a frequent event after acute stenting, and we currently lack large population results. We investigated the incidence, predictors, clinical impact stent stenting in current practice. Methods: Patients treated by with between 2015 2019 5 large-volume endovascular-capable centers were retrospectively analyzed. separated 2 groups...
Background and Purpose Recent single-center series meta-analyses suggest that mechanical thrombectomy (MT) without prior intravenous thrombolysis (IVT) might be equally effective to bridging therapy. We analyzed, within the Endovascular Treatment in Ischemic Stroke (ETIS) prospective observational registry, angiographic clinical outcomes after IVT+MT versus MT alone. Methods From December 2012 2016, a total of 1,507 consecutive patients with proximal arterial occlusion anterior circulation...
Background and Purpose— Despite the recent technical evolution of endovascular treatment acute ischemic stroke, late incomplete recanalization can be achieved after several maneuvers but with a potentially higher risk futile reperfusion complications, such as clot fragmentation. The aim this article is to investigate impact angiographic phenotype M1-middle cerebral artery occlusions, classified regular irregular in aspect, on results by stent retrievers (SRs) or contact aspiration (CA)....