A5078802748- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Retinal and Optic Conditions
- Neurological Complications and Syndromes
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Moyamoya disease diagnosis and treatment
- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- Trauma and Emergency Care Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal and Vascular Pathologies
- Vascular Malformations Diagnosis and Treatment
- Sleep and Wakefulness Research
- Advanced MRI Techniques and Applications
- Prion Diseases and Protein Misfolding
- Infectious Encephalopathies and Encephalitis
Hôpital Gui de Chauliac
2012-2023
Université de Montpellier
2013-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
University of Pisa
2021-2022
Centre Hospitalier Universitaire de Montpellier
2011-2022
Novartis (France)
2022
Hôpital Saint Eloi
2018-2021
COMUE Languedoc-Roussillon Universités
2020
The Royal Melbourne Hospital
2018
The University of Melbourne
2017-2018
Large vessel occlusion in ischemic stroke is associated with a high degree of morbidity. When intravenous thrombolysis fails, mechanical thrombectomy can provide an alternative and synergistic method for flow restoration. In this study we evaluate the safety efficacy our management protocol (RECOST study).Fifty consecutive patients large were included. After clinical MRI imaging assessment, 3 treatment strategies selected according to time symptom onset location occlusion: rescue therapy;...
<h3>BACKGROUND AND PURPOSE:</h3> Stent retriever–assisted thrombectomy promotes high recanalization rates in acute ischemic stroke. Nevertheless, complications and failures occur more than 10% of procedures; hence, there is a need for further investigation. <h3>MATERIALS METHODS:</h3> A total 144 patients with stroke presenting large-vessel occlusion were prospectively included. Patients treated stent ± IV fibrinolysis. Baseline clinical imaging characteristics incorporated univariate...
Proximal large vessel occlusion (LVO) is present in up to 30% of minor strokes. The effectiveness mechanical thrombectomy (MT) the subgroup stroke with LVO anterior circulation still open debate. Data about MT this patients are sparse, and their optimal management has not yet been defined. purpose multicenter cohort study was evaluate experiencing acute ischemic (AIS) because circulation, presenting minor-to-mild symptoms (National Institutes Health Stroke Scale score <8).Multicenter...
<h3>BACKGROUND AND PURPOSE:</h3> Internal carotid artery dissection is a common cause of stroke in young adults. It may be responsible for tandem occlusion defined by cervical steno-occlusive wall hematoma associated with an intracranial large-vessel stroke. Intravenous thrombolysis poor clinical outcome these cases, and endovascular treatment has not been specifically evaluated to date. Our aim was evaluate technical efficiency this specific topography, comparison isolated anterior...
Background A low baseline Alberta Stroke Programme Early CT Score (ASPECTS) is strongly associated with rates of favorable outcome in patients acute stroke. Objective To evaluate the efficacy and safety revascularization therapy patient ASPECTS ≤5 anterior circulation infarct. Methods We retrospectively analyzed 108 consecutive presenting on diffusion-weighted imaging. Sixty were treated by mechanical thrombectomy, including 34 who received simultaneously intravenous thrombolysis. control...
Novel thrombectomy strategies emanate expeditiously day-by-day counting on access system, clot retriever device, proximity to and integration with the thrombus, microcatheter disengagement. Nonetheless, relationship between native revascularization success remains be evaluated in basilar artery occlusion (BAO).To compare safety efficacy profile of key frontline BAO.Retrospective analyses prospectively maintained stroke registries at two comprehensive centers were performed January 2015...
Aims To evaluate the efficacy and safety of mechanical thrombectomy with Solitaire FR device in revascularization patients acute basilar artery occlusion (ABAO) to identify predictive factors for clinical outcome. Methods This prospective single-center study included 31 ischemic stroke attributable ABAO treated within first 24 h after onset symptoms device. Nineteen simultaneously received intravenous thrombolysis. Recanalization rates stent retrieval were determined outcome mortality rate...
The purpose of this study was to evaluate the benefits endovascular intervention in large-vessel occlusion strokes, depending on age class.A clinical management protocol including intravenous treatment and mechanical thrombectomy instigated our center 2009 (Prognostic Factors Related Clinical Outcome Following Thrombectomy Ischemic Stroke [RECOST] study). All patients with acute ischemic stroke an anterior circulation major-vessel who presented within 6 hours were evaluated initial MR...
Background and Purpose: Endovascular treatment of tandem occlusions is an emerging option. We describe our multicenter experience with endovascular management atherosclerotic in the anterior circulation, particularly technical aspects complications comparison to isolated intracranial occlusions. Materials Methods: Consecutive patients due causes who underwent mechanical thrombectomy at two major stroke centers between January 2010 September 2015 were reviewed. Clinical data, procedural...
Background White matter hyperintensity (WMH) has been linked to poor clinical outcomes after acute ischemic stroke. Purpose To assess whether the WMH burden on pretreatment MRI scans is associated with an increased risk for symptomatic intracranial hemorrhage (sICH) or functional outcome in patients stroke treated endovascular thrombectomy (EVT). Materials and Methods In this retrospective study, consecutive EVT anterior circulation at a comprehensive center (where was first-line imaging...
The prognosis for ischemic stroke due to acute basilar artery occlusion is very poor: Early recanalization remains the main factor that can improve outcomes. baseline extent of brain stem damage also influence We evaluated validity an easy-to-use DWI score predict clinical outcome in patients with treated by mechanical thrombectomy.We analyzed and parameters 31 occlusion, within 24 hours symptom onset using a Solitaire FR device. was assessed 12-point semiquantitative separately considered...
Approximately 30% of strokes are cryptogenic despite an exhaustive in-hospital work-up. Analysis clot composition following endovascular treatment could provide insight into stroke etiology. T-cells already have been shown to be a major component vulnerable atherosclerotic carotid lesions. We therefore hypothesize that T-cell content in intracranial thrombi may also biomarker atherothrombotic origin.We histopathologically investigated 54 consecutive retrieved after mechanical thrombectomy...
Background and purpose Inter-hospital transfer for mechanical thrombectomy (MT) might result in the of patients who finally will not undergo MT (ie, futile transfers [FT]). This study evaluated FT frequency a primary stroke center (PSC) semi-rural area at 156 km from comprehensive (CSC). Methodology Retrospective analysis data collected 6-year prospective registry concerning admitted to our PSC within 4.5 hours acute ischemic (AIS) symptom onset, with MR angiography indicating presence large...
<h3>BACKGROUND AND PURPOSE:</h3> Clinical outcomes after endovascular treatment for acute basilar artery occlusions need further investigation. Our aim was to analyze predictors of a 90-day good functional outcome defined as mRS 0–2 in MR imaging–selected patients with occlusions. <h3>MATERIALS METHODS:</h3> We analyzed consecutive endovascularly treated within the first 24 hours symptom onset. Successful and complete reperfusion modified TICI scores 2b–3 3, respectively. Outcome at 90 days...
Background and Purpose: The best anesthetic management for mechanical thrombectomy of large vessel occlusion strokes is still uncertain could impact the quality reperfusion clinical outcome. We aimed to compare efficacy safety outcomes between local anesthesia (LA) conscious sedation in a cohort acute ischemic stroke patients with anterior circulation treated current, everyday practice. Methods: Patients undergoing at 4 comprehensive centers France January 1, 2018, December 31, were pooled...
Few data are available regarding the influence of timing ischemic stroke management, such as daytime and nighttime hours, on delay mechanical thrombectomy, effectiveness revascularization, clinical outcomes. We aimed to investigate whether admission during hours could impact outcome (mRS at 90 days) patients with acute treated by thrombectomy.We retrospectively analyzed 169 (112 57 hours) in anterior cerebral circulation. The main was rate achieving functional independence days ≤2),...
<h3>BACKGROUND AND PURPOSE:</h3> Mechanical thrombectomy presents today a promising alternative to traditional stroke therapies. Our aim with this study was evaluate the safety and efficacy of Catch mechanical device in treatment acute report angiographic results clinical outcomes. <h3>MATERIALS METHODS:</h3> We performed an analysis 40 consecutive patients ischemic treated at our academic center. Forty were device: 25 anterior circulation 15 posterior stroke. Thirty seven (92.5%) received...
<h3>Objective</h3> To determine whether pretreatment cerebral microbleeds (CMBs) presence and burden are correlated with an increased risk of intracranial hemorrhage (ICH) or poor functional outcome following endovascular thrombectomy (EVT) for acute ischemic stroke (AIS). <h3>Methods</h3> Consecutive patients treated by EVT anterior circulation AIS were retrospectively analyzed. Experienced neuroradiologists blinded to outcomes rated CMBs on T2*-MRI using a validated scale. We investigated...