A5083098618- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Peripheral Artery Disease Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Retinal and Optic Conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Pituitary Gland Disorders and Treatments
- Anatomy and Medical Technology
- Augmented Reality Applications
- Neurological Disorders and Treatments
- Medical Imaging Techniques and Applications
- COVID-19 and healthcare impacts
- Autism Spectrum Disorder Research
- Vascular Procedures and Complications
- Glioma Diagnosis and Treatment
Imperial College Healthcare NHS Trust
2016-2025
Charing Cross Hospital
2015-2025
Imperial College London
2020-2025
Health and Education Research Management and Epidemiologic Services (United States)
2023
Centre Hospitalier Universitaire de Montpellier
2011-2018
Université de Montpellier
2011-2018
European Union of Medical Specialists
2017
National Health Service
2017
St Mary's Hospital
2016
University of Würzburg
2016
Mechanical thrombectomy (MT) has become the cornerstone of acute ischaemic stroke management in patients with large vessel occlusion (LVO). The aim this guideline document is to assist physicians their clinical decisions regard MT.These Guidelines were developed based on standard operating procedure European Stroke Organisation and followed Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. An interdisciplinary working group identified 15 relevant questions,...
Background Mechanical thrombectomy (MT) has become the cornerstone of acute ischemic stroke management in patients with large vessel occlusion (LVO). The aim this guideline document is to assist physicians their clinical decisions regard MT. Methods These guidelines were developed based on standard operating procedure European Stroke Organisation, and followed Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. An interdisciplinary working group identified 15...
<h3>Abstract</h3> Psychiatric traits related to categorically-defined psychiatric disorders are heritable and present varying degrees in the general population. In this study, we test hypothesis that genetic risk factors associated with also continuous variation milder population traits. We combine a contemporary twin analytic approach polygenic score (PRS) analyses large population-based sample. Questionnaires assessing of autism spectrum disorder (ASD), attention-deficit/hyperactivity...
Mechanical thrombectomy (MT) has become the cornerstone of acute ischemic stroke management in patients with large vessel occlusion (LVO).To assist physicians their clinical decisions regard toMT.These guidelines were developed based on standard operating procedure European Stroke Organisation and followed Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. An interdisciplinary working group identified 15 relevant questions, performed systematic reviews...
Large vessel occlusion in ischemic stroke is associated with a high degree of morbidity. When intravenous thrombolysis fails, mechanical thrombectomy can provide an alternative and synergistic method for flow restoration. In this study we evaluate the safety efficacy our management protocol (RECOST study).Fifty consecutive patients large were included. After clinical MRI imaging assessment, 3 treatment strategies selected according to time symptom onset location occlusion: rescue therapy;...
<h3>BACKGROUND AND PURPOSE:</h3> Stent retriever–assisted thrombectomy promotes high recanalization rates in acute ischemic stroke. Nevertheless, complications and failures occur more than 10% of procedures; hence, there is a need for further investigation. <h3>MATERIALS METHODS:</h3> A total 144 patients with stroke presenting large-vessel occlusion were prospectively included. Patients treated stent ± IV fibrinolysis. Baseline clinical imaging characteristics incorporated univariate...
Background Five randomized controlled trials recently appeared in the literature demonstrating that early mechanical thrombectomy patients with acute ischemic stroke is significantly related to an improved outcome. Stent retrievers are accepted as most effective devices for intracranial thrombectomy. Objective To analyze properties of stent retrievers, their behavior during retrieval, and interaction different clots identify device features might correlate effectiveness thrombus removal....
Background and Purpose— Recently, 5 randomized controlled trials demonstrated the benefit of endovascular therapy compared with intravenous tissue-type plasminogen activator in acute stroke. Economic evidence evaluating stent retrievers is limited. We cost-effectiveness alone versus mechanical thrombectomy as a bridging eligible patients UK National Health Service. Methods— A model-based cost-utility analysis was performed using lifetime horizon. Markov model constructed populated...
Background and purpose Prompt recanalization of cerebral arteries in patients diagnosed with acute ischemic stroke is known to be associated a better clinical outcome. The aim this study was present our initial experience regarding the efficacy safety Solitaire FR as revascularization device. Methods 56 consecutive presenting underwent intra-arterial therapy using Immediate angiographic results early outcomes are presented. Results successful achieving 50 out (89%) final Thrombolysis...
Background and purpose Prompt recanalization of cerebral arteries in patients diagnosed with acute ischemic stroke is known to be associated a better clinical outcome. The aim this study was present our initial experience regarding the efficacy safety Solitaire FR as revascularization device. Methods 56 consecutive presenting underwent intra-arterial therapy using Immediate angiographic results early outcomes are presented. Results successful achieving 50 out (89%) final Thrombolysis...
The impact on clinical outcomes of patient selection using perfusion imaging for endovascular thrombectomy (EVT) in patients with acute ischemic stroke presenting beyond 6 hours from onset remains undetermined routine practice.
ABSTRACT Background Although mechanical thrombectomy (MT) represents the standard of care for ischemic stroke due to large‐vessel occlusion (LVO), impact sex on outcomes in tandem occlusions remains unclear. We investigated sex‐based differences after MT occlusions. Methods This multicenter observational study included consecutive patients with treated across three centers (2021–2023). Propensity score matching was performed. Primary were 90‐day favorable functional outcome (mRS 0–2) and mRS...
Aims To evaluate the efficacy and safety of mechanical thrombectomy with Solitaire FR device in revascularization patients acute basilar artery occlusion (ABAO) to identify predictive factors for clinical outcome. Methods This prospective single-center study included 31 ischemic stroke attributable ABAO treated within first 24 h after onset symptoms device. Nineteen simultaneously received intravenous thrombolysis. Recanalization rates stent retrieval were determined outcome mortality rate...
<h3>BACKGROUND AND PURPOSE:</h3> Flow-diverter technology has proved to be a safe and effective treatment for intracranial aneurysm based on the concept of flow diversion allowing parent artery collateral preservation healing. We investigated patency covered side branches modification within following placement Pipeline Embolization Device in aneurysms. <h3>MATERIALS METHODS:</h3> Sixty-six aneurysms 59 patients were treated with 96 Devices. retrospectively reviewed imaging clinical results...
To evaluate the cost-effectiveness of neurothrombectomy with a stent retriever (Solitaire * Revascularization Device) in treating acute ischemic stroke patients from UK healthcare provider perspective.A Markov model was developed to simulate health outcomes and costs two therapies over lifetime time horizon: stent-retriever thrombectomy combination intravenous tissue-type plasminogen activator (IV t-PA), IV t-PA alone. The incorporated an phase (0-90 days) rest life (90+ days). Health states...
Endovascular embolization of wide-neck intracranial aneurysms can be technically challenging, especially when the anatomy is complex. Stent reconstruction parent artery commonly used to treat and bifurcated aneurysms. The main objective this study was investigate periprocedural midterm morbidity mortality results procedure.SENAT a consecutive, prospective, multicentric study. Patients with unruptured cerebral who underwent endovascular treatment Neuroform stent system were recruited...
The purpose of this study was to evaluate the benefits endovascular intervention in large-vessel occlusion strokes, depending on age class.A clinical management protocol including intravenous treatment and mechanical thrombectomy instigated our center 2009 (Prognostic Factors Related Clinical Outcome Following Thrombectomy Ischemic Stroke [RECOST] study). All patients with acute ischemic stroke an anterior circulation major-vessel who presented within 6 hours were evaluated initial MR...
The goal of this study was to assess the cost-effectiveness mechanical thrombectomy (MT) for acute ischemic stroke (AIS) from an Australian payer perspective.This used a Markov model that employed life-time time horizon, modeling patients symptom onset until end life. Clinical efficacy and safety data were taken individual patient level (IPD) meta-analysis clinical studies. treatment effect MT compared usual care measured by changes in modified Rankin Score (mRS). Post-treatment mRS scores...
Background Two recent trials demonstrated a benefit for endovascular therapy (EVT) in the treatment of basilar artery occlusion (BAO). In light expected increase use EVT BAO, we sought to understand technique preferences neurointerventionalists performing BAO. Methods We conducted an international online survey physician opinions on BAO between January and March 2022. The was distributed through stroke neurointerventional organizations. Survey questions examined selection patients procedure...
Background and Purpose Embolization is the first-line treatment for dural arteriovenous fistulas (dAVF). The precipitating hydrophobic injectable liquid (PHIL) embolic agent a non-adhesive copolymer with specific features endovascular behavior. This study assessed its safety efficacy in prospective real-life cohort. Methods PHIL-dAVF was single-arm open-label observational multicenter conducted between October 2017 November 2019 14 European centers. Patients single intracranial dAVF intended...