A5023923108- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Pelvic and Acetabular Injuries
- Spinal Cord Injury Research
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Surgical Simulation and Training
- Spinal Hematomas and Complications
- Meningioma and schwannoma management
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Management of metastatic bone disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurogenesis and neuroplasticity mechanisms
- Neurofibromatosis and Schwannoma Cases
- Spinal Dysraphism and Malformations
- Glioma Diagnosis and Treatment
- Virtual Reality Applications and Impacts
- Trauma and Emergency Care Studies
- Clinical practice guidelines implementation
- Cerebral Venous Sinus Thrombosis
- Nerve Injury and Rehabilitation
- Simulation-Based Education in Healthcare
- Trauma Management and Diagnosis
Centre Hospitalier Universitaire de Montpellier
2016-2025
Inserm
2009-2024
Hôpital Gui de Chauliac
2015-2024
Université de Montpellier
2013-2024
Institut de Psychiatrie et Neurosciences de Paris
2024
Université Paris Cité
2024
Centre Hospitalier Universitaire Amiens-Picardie
2024
Mécanismes moléculaires dans les démences neurodégénératives
2018-2021
École Pratique des Hautes Études
2017-2021
Physiologie et Médecine Expérimentale du Coeur et des Muscles
2021
The mammalian spinal cord functions as a community of cell types for sensory processing, autonomic control, and movement. While animal models have advanced our understanding cellular diversity, characterizing human biology directly is important to uncover specialized features basic function pathology. Here, we present taxonomy the adult using single-nucleus RNA sequencing with spatial transcriptomics antibody validation. We identified 29 glial clusters 35 neuronal clusters, organized...
Chronic subdural hematoma (CSDH) is a common condition requiring surgical treatment; however, recurrence occurs in 15% of cases at 1 year. Middle meningeal artery (MMA) embolization has recently emerged as promising treatment to prevent CSDH recurrence.To investigate the effect MMA on volume resorption (HVR) after surgery symptomatic patients.From April 2018 October 2018, participants with were prospectively randomized pilot study, and received either alone (ST group) or adjuvant (ST+MMAE...
No curative treatment is available for any deficits induced by spinal cord injury (SCI).Following injury, microglia undergo highly diverse activation processes, including proliferation, and play a critical role on functional recovery.In translational objective, we investigated whether transient pharmacological reduction of proliferation after beneficial recovery SCI in mice nonhuman primates.Methods: The colony stimulating factor-1 receptor (CSF1R) regulates differentiation, survival...
The anaplastic lymphoma kinase (ALK) is a receptor tyrosine known for its oncogenic potential that involved in the development of peripheral and central nervous system. ALK ligands ALKAL1 ALKAL2 were recently found to promote neuronal differentiation survival. Here, we show inflammation or injury enhanced expression subset TRPV1+ sensory neurons. Notably, was particularly enriched both mouse human peptidergic nociceptors, yet weakly expressed nonpeptidergic, large-diameter myelinated neurons...
Objective To evaluate early and mid-term imaging clinical outcomes following transvenous embolization of cerebrospinal fluid-venous fistulas (CSFVFs) in patients with spontaneous intracranial hypotension (SIH). Methods From November 2022 to 2024, 60 consecutive SIH confirmed CSFVF underwent using Onyx. Of these, 40 brain MRI pre-treatment, 24 hours post-treatment, at a 3-month follow-up. The primary outcome was regression abnormalities 3 months. Secondary included rates symptom improvement,...
Cerebral venous thrombosis (CVT) is a rare but potentially life-threatening cerebrovascular condition. Spontaneous intracranial hypotension (SIH), typically caused by cerebrospinal fluid (CSF) leaks, well-documented predisposing factor for CVT, occurring in approximately 1–2% of SIH cases. The optimal approach managing SIH-related CVT remains unclear. We report the case 63-year-old female who presented with extensive secondary to SIH. Initial treatment included low-molecular-weight heparin...
Although we are beginning to understand the late stage of neurodegenerative diseases, molecular defects associated with initiation impaired cognition poorly characterized. Here, demonstrate that in adult brain, coxsackievirus and adenovirus receptor (CAR) is located on neuron projections, at presynapse mature neurons, soma immature neurons hippocampus. In a proinflammatory or diseased environment, CAR lost from Strikingly, hippocampi patients early stages late-onset Alzheimer's disease (AD),...
Background Transvenous embolization is a recent treatment strategy for cerebrospinal fluid-venous fistulas (CSFVF), which are associated with spontaneous intracranial hypotension (SIH). Methods Participants were selected from prospective database on patients CSFVF that received transvenous Onyx embolization. All underwent brain magnetic resonance imaging (MRI) before and after MRI follow-up performed at least 3 months treatment. Clinical results described. Results Twenty-one consecutive...
Abstract The mammalian spinal cord functions as a community of glial and neuronal cell types to accomplish sensory processing, autonomic control, movement; conversely, the dysfunction these following injury or disease states can lead chronic pain, paralysis, death. While we have made great strides in understanding cellular diversity animal models, it is crucial characterize human biology directly uncover specialized features basic function illuminate pathology. Here, present taxonomy adult...
Neuroprotective and repair strategies in spinal cord injuries (SCIs) have been so far largely unsuccessful. One of the prerequisites is use appropriate preclinical models to decipher pathophysiological mechanisms; another identification optimal time windows for therapeutic interventions. The authors undertook this study characterize early motor, sensory, autonomic, histological outcomes after balloon compression at T8-9 level adult rats.A total 91 rats were used study. Spinal was performed...
Spinal cord dorsal horn inhibition is critical to the processing of sensory inputs, and its impairment leads mechanical allodynia. How this decreased occurs whether restoration alleviates allodynic pain are poorly understood. Here, we show that a step in loss inhibitory tone change firing pattern parvalbumin (PV)-expressing neurons (PVNs). Our results PV, calcium-binding protein, controls activity PVNs by enabling them sustain high-frequency tonic patterns. Upon nerve injury, transition...