A5021364327- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Photochromic and Fluorescence Chemistry
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Olfactory and Sensory Function Studies
- Viral Infections and Immunology Research
- Neurobiology and Insect Physiology Research
- Virus-based gene therapy research
- Fatty Acid Research and Health
- RNA regulation and disease
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Hormonal Regulation and Hypertension
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Viral gastroenteritis research and epidemiology
- Neurological diseases and metabolism
Université de Montpellier
2013-2025
École Pratique des Hautes Études
2008-2025
Inserm
2013-2025
Centre National de la Recherche Scientifique
2008-2024
Institut de Génomique Fonctionnelle
2016-2024
Université Laval
2024
Mécanismes moléculaires dans les démences neurodégénératives
2019-2021
Institut de Génétique Moléculaire de Montpellier
2013-2018
Institut des Maladies Neurodégénératives
2010
Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence of senile plaques and neurofibrillary tangles, accompanied synaptic neuronal loss. The major component an amyloid β protein (Aβ) formed pathological processing Aβ precursor protein. We assessed time-course regional effects single intracerebroventricular injection aggregated fragment 25–35 (Aβ25-35) in rats. Using combined biochemical, behavioral, morphological approach, we analyzed peptide after 1, 2, 3...
Alzheimer's disease (AD) is a neurodegenerative pathology associated with aging characterized by the presence of senile plaques and neurofibrillary tangles that finally result in synaptic neuronal loss. The major component an amyloid-β protein (Aβ). Recently, we effects single intracerebroventricular (icv) injection Aβ fragment (25–35) oligomers (oAβ25–35) for up to 3 weeks rats established clear parallel numerous relevant signs AD. To clarify long-term oAβ25–35 its potential role...
Reduced docosahexaenoic acid (DHA) concentrations seem to be associated with an increased risk of Alzheimer's disease (AD), and DHA accretion the brain across blood-brain-barrier (BBB) can modulated by various factors. Therefore, there is urgent need identify efficient non-invasive method ensure enrichment. In present study, a safe stable DHA-enriched nanoemulsion, designed protect against oxidation, was administered intranasally in transgenic mouse model AD, J20 mice. Intranasal treatment...
Exposure to chronic stress and high levels of glucocorticoid hormones in adulthood has been associated with cognitive deficits increased risk Alzheimer's disease (AD). Dazucorilant recently emerged as a selective receptor (NR3C1) modulator, exhibiting efficacy counteracting amyloid-β toxicity an acute model AD. We aim assess the therapeutic potential dazucorilant reversing amyloid tau pathologies through inhibition pathological activity, providing additional evidence for its consideration AD...
Phenylazopyridines are photoisomerizable compounds with high potential to control biological functions light. We have obtained a series of phenylazopyridines light dependent activity as negative allosteric modulators (NAM) metabotropic glutamate receptor subtype 5 (mGlu5). Here we describe the factors needed achieve an operational molecular photoisomerization and its effective translation into in vitro vivo photoswitching, which includes zebrafish larva motility regulation antinociceptive...
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that has important health and economic impacts in the elderly. Despite better understanding of molecular pathogenesis mechanisms leading to appearance major pathological hallmarks disease (senile plaques neurofibrillary tangles), effective treatments are still lacking. Sporadic AD forms (98% all cases) aare multifactorial pathology, its complexity could be explained by panoply risk factors have been identified. While tThe...
Abstract Action control is a key brain function determining the survival of animals in their environment. In mammals, neurons expressing dopamine D2 receptors (D2R) dorsal striatum (DS) and nucleus accumbens (Acb) jointly but differentially contribute to fine regulation movement. However, region-specific molecular features are presently unknown. By combining RNAseq striatal D2R histological analyses, we identified hundreds novel markers, which may serve as tools target selective...
Abstract Objective Although epilepsies and neurodegenerative disorders show pathophysiological similarities, their direct functional associations are unclear. Here, we tested the hypothesis that experimental seizures can induce tau hyperphosphorylation amyloidogenic modifications over time, with intersections neuroinflammation. Methods We used a model of mesial temporal lobe epilepsy (MTLE) where unilateral intrahippocampal injection kainic acid (KA) in C57BL/6 mice elicits epileptogenesis...
Polyunsaturated fatty acids (PUFAs) are a class of that closely associated with the development and function brain. The most abundant PUFA is docosahexaenoic acid (DHA, 22:6 n-3). In humans, low plasmatic concentrations DHA have been impaired cognitive function, hippocampal volumes, increased amyloid deposition in Several studies reported reduced brain Alzheimer's disease (AD) patients' brains. Although number epidemiological suggest dietary consumption may protect elderly from developing...
The multifactorial origin and neurochemistry of Alzheimer's disease (AD) call for the development multitarget treatment strategies. We report a first-in-class triple acting compound that targets serotonin type 6 3 receptors (5-HT-Rs) monoamine oxidase B (MAO-B) as an approach treating AD. key structural features required MAO-B inhibition 5-HT6R antagonism interaction with 5-HT3R were determined using molecular dynamic simulations cryo-electron microscopy, respectively. Bioavailable PZ-1922...
Although we are beginning to understand the late stage of neurodegenerative diseases, molecular defects associated with initiation impaired cognition poorly characterized. Here, demonstrate that in adult brain, coxsackievirus and adenovirus receptor (CAR) is located on neuron projections, at presynapse mature neurons, soma immature neurons hippocampus. In a proinflammatory or diseased environment, CAR lost from Strikingly, hippocampi patients early stages late-onset Alzheimer's disease (AD),...
Abstract Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis occurs early in Alzheimer's disease (AD), associated with elevated circulating glucocorticoids (GC) and glucocorticoid receptors (GR) signaling impairment. However, precise role GR pathophysiology AD remains unclear. Using an acute model induced by intracerebroventricular injection amyloid‐β oligomers (oAβ), we analyzed cellular behavioral hallmarks AD, pathways, processing amyloid precursor protein, enzymes involved Tau...
Brain-derived neurotrophic factor (BDNF) appears to be highly involved in hypothalamic-pituitary-adrenal (HPA) axis regulation during adulthood, playing an important role homeostasis maintenance. The present study aimed determine the involvement of BDNF HPA activity under basal and stress conditions via partial inhibition this endogenous neurotrophin. Experiments were conducted rats mice with two complementary approaches: (i) knockdown stereotaxic delivery BDNF-specific small interfering RNA...
Parkinson's disease (PD) is the second most prevalent neurodegenerative among elderly. To understand its pathogenesis and to test therapies, animal models that faithfully reproduce key pathological PD hallmarks are needed. As a prelude developing model of PD, we tested tropism, efficacy, biodistribution, transcriptional effect canine adenovirus type 2 (CAV-2) vectors in brain Microcebus murinus, nonhuman primate naturally develops lesions. We show introducing helper-dependent (HD) CAV-2...
G protein-coupled receptors (GPCR), including the metabotrobic glutamate 5 receptor (mGlu5), are important therapeutic targets and development of allosteric ligands for targeting GPCRs has become a desirable approach toward modulating activity. Traditional pharmacological approaches GPCR activity still limited since precise spatiotemporal control ligand is lost as soon it administered. Photopharmacology proposes use photoswitchable to overcome this limitation, their can be reversibly...
Abstract Knowing the site of drug action is important to optimize effectiveness and address any side effects. We used light-sensitive drugs identify brain region-specific role mGlu5 metabotropic glutamate receptors in control pain. Optical activation systemic JF-NP-26, a caged, normally inactive, negative allosteric modulator (NAM) receptors, cingulate, prelimbic infralimbic cortices thalamus inhibited neuropathic pain hypersensitivity. Systemic treatment alloswitch-1, an intrinsically...
Alzheimer's disease (AD) is a multifactorial neurodegenerative with complex origin, thought to involve combination of genetic, biological and environmental factors. Insulin dysfunction has emerged as potential factor contributing AD pathogenesis, particularly in individuals diabetes, among those insulin deficiency or undergoing therapy. The intraperitoneal administration streptozotocin (STZ) widely used rodent models explore the impact on pathology, although prior research predominantly...
<b><i>Introduction:</i></b> Among the risk factors identified in sporadic forms of Alzheimer’s disease (AD), environmental and lifestyle elements are growing interest. Clinical observations suggest that stressful events can anticipate AD onset, while stress-related disorders promote AD. Here, we tested hypothesis a chronic treatment with glucocorticoids is sufficient to trigger or exacerbate molecular hallmarks. <b><i>Methods:</i></b> We first...