A5107541348- Functional Brain Connectivity Studies
- Rheology and Fluid Dynamics Studies
- Surfactants and Colloidal Systems
- Pickering emulsions and particle stabilization
- Advanced Neuroimaging Techniques and Applications
- Material Dynamics and Properties
- Cellular Mechanics and Interactions
- Meat and Animal Product Quality
- Advanced MRI Techniques and Applications
- Growth Hormone and Insulin-like Growth Factors
- Neural and Behavioral Psychology Studies
- Regulation of Appetite and Obesity
- Block Copolymer Self-Assembly
- Liquid Crystal Research Advancements
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- 3D Printing in Biomedical Research
- Theoretical and Computational Physics
- Circadian rhythm and melatonin
- Aeolian processes and effects
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Animal Nutrition and Physiology
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
Université de Montpellier
2012-2022
Laboratoire Charles Coulomb
2013-2022
Centre National de la Recherche Scientifique
2004-2022
Centre Hospitalier Universitaire de Montpellier
2021
Hôpital Gui de Chauliac
2016-2020
Institut d'Imagerie Biomédicale
2019
Inserm
2010-2018
Institut de Génomique Fonctionnelle
2008-2018
Laboratoire de Physique Théorique
2016
Centro de Investigación y Tecnología Agroalimentaria de Aragón
2015
To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules therefore be able to circumvent tightly sealed vasculature blood-brain barrier rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed central remains largely unexplored. Using vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate...
Using dynamic light scattering in heterodyne mode, we measure velocity profiles a much studied system of wormlike micelles (CPCl/NaSal) known to exhibit both shear-banding and stress plateau behavior. Our data provide evidence for the simplest scenario, according which effective viscosity drop is due nucleation growth highly sheared band gap, whose thickness linearly increases with imposed shear rate. We discuss various details all regions flow curve emphasize complex, non-Newtonian nature band.
Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent properties are present populations organized as networks within endocrine tissues involved regulating body-wide homeostasis. Here we show, using lactation repeatedly activate a...
OBJECTIVE The supplementary motor area (SMA) syndrome is a well-studied lesional model of brain plasticity involving the sensorimotor network. Patients with diffuse low-grade gliomas in SMA may exhibit this after resective surgery. They experience temporary loss function, which completely resolves within 3 months. authors used functional MRI (fMRI) resting state analysis network to investigate large-scale between immediate postoperative period and months' follow-up. METHODS Resting fMRI was...
Abstract Objectives To validate the functional relevance of resting state networks (RSNs) by means a comparison connectivity (RSC) between language regions elicited direct cortical stimulation versus RSC random regions; and to evaluate accuracy fMRI in surgical planning assessing overlap RSNs intraoperative mapping results. Methods Sensorimotor eloquent sites were identified electrical 98 patients with diffuse low‐grade glioma. A seed voxel analysis inter‐language point inter‐random ROIs was...
There are well-recognized sex differences in many pituitary endocrine axes, usually thought to be generated by gonadal steroid imprinting of the neuroendocrine hypothalamus. However, recognition that growth hormone (GH) cells arranged functionally organized networks raises possibility responses network different males and females. We studied this directly monitoring calcium an identical GH-releasing (GHRH) stimulus populations individual GH slices taken from male female murine GH-eGFP...
Ghrelin targets the arcuate nucleus, from where growth hormone releasing (GHRH) neurones trigger GH secretion. This hypothalamic nucleus also contains neuropeptide Y (NPY) neurons which play a master role in effect of ghrelin on feeding. Interestingly, connections between NPY and GHRH have been reported, leading to hypothesis that axis feeding circuits might be co-regulated by ghrelin.Here, we show stimulates firing rate identified neurons, transgenic GHRH-GFP mice. stimulation is prevented...
Growth hormone (GH) exerts its actions via coordinated pulsatile secretion from a GH cell network into the bloodstream. Practically nothing is known about how receives inputs in vivo and releases hormones pituitary capillaries to shape pulses. Here we have developed approaches measure local blood flow, oxygen partial pressure, activity at single-cell resolution mouse glands situ. When secretagogue (GHRH) distribution was modeled with fluorescent markers injected either bloodstream or nearby...
We report evidence for two distinct strain-induced orientation transitions in a lyotropic bcc cubic crystal submitted to increasing shear rates. The is built up from copolymer spherical micelles selective solvent. distribution of orientations characterized by x-ray diffraction: the oriented states, dense <111> rows align along flow, but they differ each other layers with respect plane. These have clear rheological signatures form stress plateaus associated coexistence states orientation....
The dynamic connectome perspective states that brain functions arise from the functional integration of distributed and/or partly overlapping networks. Diffuse low-grade gliomas (DLGG) have a slow infiltrating character. Here we addressed whether and how anatomical disconnection following DLGG growth resection might interfere with resting-state connectivity, specifically in relation to picture naming. Thirty-nine native French persons left were included. All underwent awake surgical tumor...
We study theoretically a model system of transient network microemulsion droplets connected by telechelic polymers and explain recent experimental findings. Despite the absence any specific interactions between either or polymer chains, we predict that as number per drop is increased, undergoes first-order phase separation into dense, highly phase, in equilibrium with dilute droplets, decorated loops. The transition purely entropic driven interplay translational entropy drops configurational...
The mammalian circadian system is composed of multiple peripheral clocks that are synchronized by a central pacemaker in the suprachiasmatic nuclei hypothalamus. This keeps track external world rhythms through entrainment various time cues, such as light-dark cycle and feeding schedule. Alterations photoperiod meal modulate phase coupling between oscillators. In this study, we used real-time quantitative PCR to assess clock gene expression liver pituitary gland from mice raised under...
Pancreatic β-cells modulate insulin secretion through rapid sensing of blood glucose and integration gut-derived signals. Increased demand during pregnancy obesity alters islet function mass leads to gestational diabetes mellitus type 2 in predisposed individuals. However, it is unclear how blood-borne factors dynamically access the islets Langerhans. Thus, understanding changes circulating molecule distribution that accompany compensatory β-cell expansion may be key developing novel...
We have measured the nonlinear rheological response of a model transient network over large range steady shear rates. The system is built up from an oil in water droplet microemulsion into which telechelic polymer incorporated. phase behaviour characterized comprises liquid-gas separation and percolation threshold. measurements are performed one region above line. Shear thinning observed for all samples, leading most cases to unstable stress at intermediate very simple mean field involves...
We use small-angle X-ray scattering to investigate the structures under shear of surfactant hexagonal phases swollen with oil. Rheology studies these materials indicate a shear-induced transition between two states different viscosity. In low regime, cylinders are preferentially oriented along flow and phase exhibits polycrystalline texture. Unexpectedly, high has effect melting long-range two-dimensional (2D) order cylinders, leading 2D liquid strongly aligned flow.
The shear-thickening transition observed in aqueous solutions of cetyltrimethylammonium tosylate (CTAT) is investigated using rheology and small-angle neutron scattering under shear. Above a critical shear rate C, the increase apparent viscosity due to formation shear-induced phase. Using Porod representation analyze aggregate local morphology, we demonstrate that viscous state consists cylindrical micelles strongly aligned flow. We also investigate surfactant concentration dependencies...
Few data are available regarding the influence of timing ischemic stroke management, such as daytime and nighttime hours, on delay mechanical thrombectomy, effectiveness revascularization, clinical outcomes. We aimed to investigate whether admission during hours could impact outcome (mRS at 90 days) patients with acute treated by thrombectomy.We retrospectively analyzed 169 (112 57 hours) in anterior cerebral circulation. The main was rate achieving functional independence days ≤2),...