Nicolas Gaillard
A5102999192- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Atrial Fibrillation Management and Outcomes
- Cerebral Venous Sinus Thrombosis
- Neurological Complications and Syndromes
- Infectious Encephalopathies and Encephalitis
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Herpesvirus Infections and Treatments
- Renal and Vascular Pathologies
- Neurological and metabolic disorders
- Polyomavirus and related diseases
- Vasculitis and related conditions
- Autoimmune Neurological Disorders and Treatments
- Congenital Heart Disease Studies
- Sarcoidosis and Beryllium Toxicity Research
- Mosquito-borne diseases and control
- Long-Term Effects of COVID-19
- Retinal and Optic Conditions
- Cerebrospinal fluid and hydrocephalus
- Moyamoya disease diagnosis and treatment
Centre Hospitalier de Perpignan
2013-2025
Hôpital Gui de Chauliac
2009-2024
Clinique du Millénaire
2024
Université de Montpellier
2017-2023
Centre Hospitalier Universitaire de Montpellier
2008-2023
University of Pisa
2021-2022
Inserm
1993-2021
Hôpital Robert-Debré
2021
Hôpital Saint Eloi
2018-2021
COMUE Languedoc-Roussillon Universités
2020
Background and Purpose: The efficiency of prehospital care chain response the adequacy hospital resources are challenged amid coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients ischemic stroke eligible mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection treated MT, ranging 45 days across epidemic containment measures instatement, during same calendar period in 2019. primary end point was variation receiving MT...
Objective To describe characteristics and outcomes of a multicenter cohort patients diagnosed as having primary angiitis the central nervous system (PACNS). Methods In 2010, we initiated study adults PACNS ≤15 years ago with followup >6 months (unless they died earlier biopsy‐proven PACNS). Its first analysis was planned at 2 years. Multidisciplinary investigators verified that appropriate investigations were done excluded possible alternative diagnoses. We analyzed patient demographics...
Proximal large vessel occlusion (LVO) is present in up to 30% of minor strokes. The effectiveness mechanical thrombectomy (MT) the subgroup stroke with LVO anterior circulation still open debate. Data about MT this patients are sparse, and their optimal management has not yet been defined. purpose multicenter cohort study was evaluate experiencing acute ischemic (AIS) because circulation, presenting minor-to-mild symptoms (National Institutes Health Stroke Scale score <8).Multicenter...
<h3>Introduction</h3> Over half of patients with irritable bowel syndrome have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy licensed pharmacological therapies in IBS-D and IBS-M is unclear the absence head-to-head trials. We conducted network meta-analysis to resolve this uncertainty. <h3>Methods</h3> searched MEDLINE, EMBASE, EMBASE Classic, Cochrane central register controlled trials, clinicaltrials.gov through November 2018 identify randomised trials...
Primary familial brain calcification (PFBC) is a rare neurogenetic disorder with diverse neuropsychiatric expression. Mutations in four genes cause autosomal dominant PFBC: SLC20A2, XPR1, PDGFB and PDGFRB. Recently, biallelic mutations the MYORG gene have been reported to PFBC an recessive pattern of inheritance. We screened 29 unrelated probands negatively for identified 11 families or novel predicted damaging variant. studied clinical radiological features 16 patients these compared them...
<h3>Background and Objective</h3> <i>PRRT2</i> variants have been reported in a few cases of patients with hemiplegic migraine. To clarify the role familial migraine, we studied this gene large cohort affected probands. <h3>Methods</h3> was analyzed 860 probands variations were identified 30 Genotyping relatives total 49 persons whose clinical manifestations detailed. <h3>Results</h3> found 12 163 who previously tested negative for <i>CACNA1A</i>, <i>ATP1A2</i>, <i>SCN1A</i> 18 697...
Background White matter hyperintensity (WMH) has been linked to poor clinical outcomes after acute ischemic stroke. Purpose To assess whether the WMH burden on pretreatment MRI scans is associated with an increased risk for symptomatic intracranial hemorrhage (sICH) or functional outcome in patients stroke treated endovascular thrombectomy (EVT). Materials and Methods In this retrospective study, consecutive EVT anterior circulation at a comprehensive center (where was first-line imaging...
Importance Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and associated with the of disease activity, but data on benefits supplementation are conflicting. Objective To evaluate efficacy high-dose cholecalciferol as monotherapy in reducing activity patients clinically isolated syndrome (CIS) typical MS. Design, Setting, Participants The D-Lay MS trial was parallel, double-blind, randomized placebo-controlled clinical 36 centers France. Patients were enrolled from July...
We aimed to analyse the effect of maintenance therapy after induction on outcomes adult patients with primary angiitis CNS (PACNS).We analysed long-term (relapse, survival and functional status) enrolled in French multicentre PACNS cohort who achieved remission treatment ⩾12 months' follow-up, according whether or not they received therapy. Good outcome was defined as relapse-free good status (modified Rankin scale ⩽ 2) at last follow-up.Ninety-seven [46 (47%) female, median age: 46 (18-78)...
Background and purpose Inter-hospital transfer for mechanical thrombectomy (MT) might result in the of patients who finally will not undergo MT (ie, futile transfers [FT]). This study evaluated FT frequency a primary stroke center (PSC) semi-rural area at 156 km from comprehensive (CSC). Methodology Retrospective analysis data collected 6-year prospective registry concerning admitted to our PSC within 4.5 hours acute ischemic (AIS) symptom onset, with MR angiography indicating presence large...
The epidemiology and prognosis of chronic kidney disease (CKD) differ by sex. We aimed to compare symptom prevalence the clinical state in women men ≥65 years age with advanced CKD receiving routine nephrology care.The European QUALity study on treatment (EQUAL) follows patients from six countries whose estimated glomerular filtration rate (eGFR) dropped ≤20 mL/min/1.73 m2 for first time during last 6 months. Dialysis Symptom Index was used assess severity 33 uraemic symptoms. Data at...
New diagnostic tools have been developed to improve the diagnosis of infectious encephalitis. Using a prospective cohort encephalitis patients, our objective was identify possible clusters patients with similar patterns among unknown cause (EUC) and describe what extent patient's initial presentation may be predictive etiology, particularly herpes simplex virus (HSV) varicella-zoster (VZV).The National Cohort Infectious Encephalitis in France is an ongoing study implemented 2016. Patients...
Background No comprehensive study exists about mechanical thrombectomy accessibility for patients admitted to a primary stroke center without onsite interventional neuroradiology service. Aims To evaluate within 6 h after transfer from distant (156 km apart; 1.5 by car) center. Methods Analysis of data collected in three-year prospective registry on 4.5 symptom onset and selected thrombectomy. Eligible had confirmed proximal arterial occlusion no large cerebral infarction MRI images...
<h3>BACKGROUND AND PURPOSE:</h3> Clinical outcomes after endovascular treatment for acute basilar artery occlusions need further investigation. Our aim was to analyze predictors of a 90-day good functional outcome defined as mRS 0–2 in MR imaging–selected patients with occlusions. <h3>MATERIALS METHODS:</h3> We analyzed consecutive endovascularly treated within the first 24 hours symptom onset. Successful and complete reperfusion modified TICI scores 2b–3 3, respectively. Outcome at 90 days...
Introduction: Cerebral venous thrombosis (CVT) is a rare disease with highly variable clinical presentation and outcome. Etiological assessment may be negative. The radiological evolution can variable. mechanisms involved in this variability remain unknown. Objective: aim of multicenter French study registered on ClinicalTrials.gov (NCT02013635) was therefore to prospectively recruit cohort patients cerebral (FPCCVT) order thrombin generation clot degradation, evaluate their influence...
282 References 1 Tallroth G, Ryding E, Agardh CD: Regional cerebral blood flow in normal man during insulin-induced hypoglycemia and the recovery period following glucose infusion. Metabolism1992; 41: 717–721. 2 Wattoo MA, Liu HH: Alternating transient dense hemiplegia due to episodes of hypoglycemia. West J Med 1999; 170: 170–171. 3 Vanpee D, Donckier J, Gillet JB: Hemiplegia syndrome. Eur Emerg 6: 157–159. 4 Bolyn-Starks L: Hypoglycemic hemiplegia: a case study. Heart Lung 1995; 24:...
Background: Cerebral amyloid angiopathy (CAA) can be associated with primary vasculitis of small/medium-sized leptomeningeal and cortical arteries, called CAA-related inflammation (CAA-ri). Objective: To compare hemorrhagic diffusion-weighted imaging (DWI) MRI features in CAA CAA-ri. Methods: We prospectively scored a consecutive CAA-ri cohort: presence/number chronic intracerebral hemorrhage (ICH), cerebral microbleeds (CMB), superficial siderosis (CSS) on initial T2*-weighted imaging, DWI...