Simon Escalard
A5018010330- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Vascular Malformations Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Intracerebral and Subarachnoid Hemorrhage Research
- Aortic aneurysm repair treatments
- Retinal and Optic Conditions
- Peripheral Artery Disease Management
- Neurosurgical Procedures and Complications
- Neurological Disease Mechanisms and Treatments
- Cerebral Venous Sinus Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Central Venous Catheters and Hemodialysis
- Sepsis Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
Fondation de Rothschild
2016-2025
Fondation Ophtalmologique Adolphe de Rothschild
2016-2025
St. Antonius Ziekenhuis
2023
Hospital de Egas Moniz
2022
University of Thessaly
2022
Boston University
2022
Boston Medical Center
2022
Assistance Publique – Hôpitaux de Paris
2019-2020
Inserm
2019
Université Paris Cité
2019
Background and Purpose: The efficiency of prehospital care chain response the adequacy hospital resources are challenged amid coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients ischemic stroke eligible mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection treated MT, ranging 45 days across epidemic containment measures instatement, during same calendar period in 2019. primary end point was variation receiving MT...
Background and Purpose: Higher rates of strokes have been observed in patients with coronavirus disease 2019 (COVID-19), but data regarding the outcomes COVID-19 suffering from acute ischemic stroke due to large vessel occlusion (LVO) are lacking. We report our initial experience treatment LVO COVID-19. Methods: All consecutive treated institution during 6 first weeks outbreak were included. Baseline clinical radiological findings, treatment, short-term reported. Results: identified 10...
Background and Purpose— Acute stroke patients with a large ischemic core may still benefit from mechanical thrombectomy (MT), but the predictors of clinical outcome are not well known after MT. We investigated imaging factors associated good mortality at 90 days in acute baseline treated Methods— Data multicentric prospective ETIS (Endovascular Treatment Ischemic Stroke) registry consecutive MT January 1, 2012, to August 31, 2016, were retrospectively analyzed. Baseline was defined as...
Background and Purpose: Endovascular therapy for tandem occlusion strokes of the anterior circulation is an effective safe treatment. The best treatment approach cervical internal carotid artery (ICA) lesion still unknown. In this study, we aimed to compare functional safety outcomes between different approaches ICA during endovascular acute ischemic due in current clinical practice. Methods: Individual patients’ data were pooled from French prospective multicenter observational ETIS...
Background and Purpose— Parenchymal hematoma (PH) is a rare but dreadful complication of acute ischemic stroke with unclear underlying mechanisms. We aimed to study the incidence predictors PH after mechanical thrombectomy. Methods— Data from prospective observational multicenter registry was screened identify patients an anterior circulation large vessel occlusion who underwent Clinical, imaging, procedural characteristics were used for analysis, including brain imaging systematically...
Background and Purpose— Nonagenarians represent a growing stroke population characterized by higher frailty. Although endovascular therapy (ET) is cornerstone of the management acute ischemic related to large vessel occlusion, benefit reperfusion among nonagenarians poorly documented. We aimed assess impact ET-related on functional outcome in this elderly population. Methods— A retrospective analysis clinical imaging data from all patients aged over 90 included ETIS (Endovascular Treatment...
Background and Purpose: Although the efficacy of endovascular treatment (EVT) in patients with anterior circulation ischemic stroke (AIS) is well documented, early neurological deterioration after EVT remains a serious issue associated poor outcome. Besides obvious causes, such as lack reperfusion, procedural complications, or parenchymal hemorrhage, may remain unexplained (UnEND). Our aim was to investigate predictors UnEND AIS. Methods: Patients who underwent for AIS, an initial National...
The mechanisms and outcomes in coronavirus disease (COVID-19)-associated stroke are unique from those of non-COVID-19 stroke.To describe the efficacy acute revascularization large vessel occlusion (LVO) setting COVID-19 an international cohort.We conducted multicenter retrospective study consecutively admitted patients with concomitant LVO across 50 comprehensive centers. Our control group constituted historical controls presenting receiving a mechanical thrombectomy between January 2018...
Background Middle meningeal artery (MMA) embolization has been proposed as a treatment of chronic subdural hematoma (CSDH). The benefit the procedure yet to be demonstrated in randomized controlled trial. We aim assess efficacy MMA reducing risk CSDH recurrence 6 months after burr-hole surgery compared with standard medical patients at high postoperative recurrence. Methods EMPROTECT trial is multicenter open label (RCT) involving 12 French centers. Adult (≥18 years) operated for or first...
Objective During thrombectomy, thromboembolic migration in previously unaffected territory may occur and is not systematically notified. We report our data on the incidence, predictors, clinical outcome of anterior cerebral artery emboli (ACAE). Methods From a prospectively collected thrombectomy database consecutive patients with circulation stroke between January 2012 December 2016, 690 angiographic images were analyzed to assess ACAE. The primary was favorable outcome, defined as 3 month...
To identify early prognostic factors of poor clinical outcome in patients treated by endovascular therapy (EVT) with successful recanalization.We reviewed our monocentric prospectively collected EVT database anterior circulation acute ischemic stroke (AIS) from January 2016 to April 2018 who had achieved recanalization (Thrombolysis Cerebral Infarction score ≥ 2b) at the end procedure. A was defined as a 3-month modified Rankin Scale ≥3.A total 324 were included, among whom 186 (57.4%)...
Reports are emerging regarding the association of acute ischemic strokes with large vessel occlusion and coronavirus disease 2019 (COVID-19). While a higher severity these patients could be expected from addition both respiratory neurological injury, COVID-19 can present mild or none symptoms. We aimed to compare anterior circulation between without COVID-19.
The efficacy of endovascular therapy in patients with acute ischemic stroke due to tandem occlusion is comparable that for isolated intracranial the anterior circulation. However, optimal management cervical internal carotid artery lesions unknown, especially setting dissection, but emergency stenting (CAS) frequently considered. We investigated safety and CAS dissection current clinical practice. retrospectively analyzed a prospectively maintained database composed 2 merged multicenter...
Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated incidence, risk factors, and clinical implications daily practice.We used data from ongoing prospective multicenter observational Endovascular Treatment Ischemic Stroke Registry France. The present study is a retrospective analysis 4029 stroke patients with treated between January 2015 May 2020 18 centers. systematically collected procedural data, incidence...
To investigate in routine care the efficacy and safety of IV thrombolysis (IVT) with tenecteplase prior to mechanical thrombectomy (MT) patients large vessel occlusion acute ischemic strokes (LVO-AIS), either secondarily transferred after IVT or directly admitted a comprehensive stroke center (CSC).We retrospectively analyzed clinical procedural data treated 0.25 mg/kg within 270 minutes LVO-AIS who underwent brain angiography. The main outcome was 3-month functional independence (modified...
<h3>Background and Objectives</h3> COVID-19–related inflammation, endothelial dysfunction, coagulopathy may increase the bleeding risk lower efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate safety outcomes AIS COVID-19. <h3>Methods</h3> This was a retrospective multicenter cohort study consecutive receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 June 2021 tested for severe respiratory...
Brain arteriovenous malformations (AVMs) pose a significant treatment challenge, with current options including microsurgical resection, endovascular embolization, radiosurgery, or combinations thereof. Here, we present our experience curative strategy combining complete followed by resection under the same anesthesia session, without relying on hybrid operating room. We reviewed consecutive AVM patients who underwent (EVT) and (MS) in single session (COMBI-AVM protocol) from December 2017...
BACKGROUND: Transvenous embolization (TVE) is a new treatment of brain arteriovenous malformations (AVMs). The safety and efficacy TVE have not been compared with transarterial (TAE). primary hypothesis this trial was that would increase the proportion AVM occlusion from 40% to 80%. METHODS: TATAM (Transvenous Approach for Treatment Cerebral AVMs) an investigator-initiated, multicenter, prospective, phase 2, open-label, controlled randomized comparing versus TAE alone (1:1). Patients...
Surgical resection is usually considered as the first-line curative strategy for low-grade (Spetzler-Martin grade I-II) brain arteriovenous malformations because it has a high cure rate and low complications. The role of endovascular treatment remains to be clarified in this indication, especially after A Randomized Trial Unruptured Brain Arteriovenous Malformations. Our objective was assess safety efficacy malformation management at our institution.Patients with treated primarily...
Self-expandable stents have broadened the spectrum of endovascular treatment intracranial aneurysms. However, procedures involving double stenting in Y/X configurations carry a relatively high risk procedural complications. The Neuroform ATLAS, evolution EZ, is nitinol self-expanding hybrid/open cell stent which can be delivered through low profile 0.017 inch catheter. We present our experience aneurysms with this Y and X configurations.We prospectively maintained database from consecutive...