A5043185027- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Long-Term Effects of COVID-19
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Atrial Fibrillation Management and Outcomes
- Autoimmune Neurological Disorders and Treatments
- Neurological Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Myasthenia Gravis and Thymoma
- COVID-19 and healthcare impacts
- Porphyrin Metabolism and Disorders
- Head and Neck Surgical Oncology
- Parkinson's Disease Mechanisms and Treatments
- Polyomavirus and related diseases
- Cerebrovascular and genetic disorders
- Neonatal Health and Biochemistry
- Retinal and Optic Conditions
- Alzheimer's disease research and treatments
- Digital Mental Health Interventions
Clinical Emergency Hospital Bucharest
2011-2025
Carol Davila University of Medicine and Pharmacy
2014-2025
Hospital de Egas Moniz
2022
University of Thessaly
2022
Boston University
2022
Boston Medical Center
2022
Emergency University
2012-2020
Amita Health St. Mary's Hospital
2020
Alexandria University
2020
University of Bucharest
2016
Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aim To summarize the findings multinational observational cohort patients SARS-CoV-2 and cerebrovascular disease. Methods Retrospective consecutive adults evaluated emergency department and/or admitted coronavirus disease 2019 (COVID-19) across 31 hospitals four countries (1 February 2020–16 June 2020). The primary outcome was...
<b><i>Background:</i></b> Patients who present with symptoms mimicking ischaemic stroke (IS), but have a different diagnosis, are known as mimics (SM). The necessity for rapid administration of intravenous thrombolysis in patients acute IS may lead to treatment conditions stroke. A variable proportion SM (1.4–14%) currently treated tissue plasminogen activator therapy (IV-tPA). outcome these is generally favourable and complications rather infrequent. We aimed...
Background and objectives: The time interval between stroke onset hospital arrival is a major barrier for reperfusion therapies in acute ischemic usually accounts most of the onset-to-treatment delay. present study aimed to analyze pre-hospital delays patients with admitted tertiary center Romania identify factors associated late arrival. Material methods: population consisted 770 hospitalized diagnosis University Emergency Hospital Bucharest during 6-month period, 1 January 30 June 2018....
Background Widespread use of ocrelizumab, an anti-CD20 monoclonal antibody, for treating patients with multiple sclerosis (MS), has led to increase in reported adverse events following real-world observation. Among these, drug-induced colitis is a rare, but severe side effect, prompting recent FDA statement regarding this safety concern. Objectives: We analyzed cohort ocrelizumab treated our MS center evaluate the incidence colitis. Methods present critical review available literature on...
Introduction: Evidence regarding the benefit of endovascular therapy (EVT) in patients with acute ischemic stroke (AIS) due to isolated cervical internal carotid artery occlusion (c-ICA-O) is lacking. We assessed outcomes and safety EVT c-ICA-O. Methods: Retrospective multicenter cohort study an AIS c-ICA-O, within 24-h since last-seen-well. Comparisons were made between best medical (BMT). The primary outcome was 3-months modified Rankin Scale (mRS) ordinal shift. Secondary included 3-month...
Opsoclonus-myoclonus syndrome (OMS) is a very rare condition with different autoimmune, infectious and paraneoplastic aetiologies or in most cases idiopathic. We report the case of 75-year-old woman who was admitted our department early fall for altered mental status, opsoclonus, multifocal myoclonus, truncal titubation generalized tremor, preceded by 5 day prodrome consisting malaise, nausea, fever vomiting. Brain computed tomography MRI scans showed no significant abnormalities...
Romania has one of the highest incidences stroke and mortality rates in Europe. The rate due to treatable causes is also very high associated with lowest public spending on healthcare European Union. Nonetheless, significant achievements acute care have been made last 5 years, most notably increase national thrombolysis from 0.8% 5.4%. Numerous educational workshops constant communication centers led a solid active network. Due joint efforts this network ESO-EAST project, quality...
Background and Objectives: Neutrophil-to-lymphocyte ratio (NLR), a very low cost, widely available marker of systemic inflammation, has been proposed as potential predictor short-term outcome in patients with intracerebral hemorrhage (ICH). Methods: Patients ICH admitted to the Neurology Department during two-year period were screened for inclusion. Based on eligibility criteria, 201 included present analysis. Clinical, imaging, laboratory characteristics collected prespecified manner....
(1) Background: Cognitive impairment (CI) begins early in the evolution of multiple sclerosis (MS) but may only become obvious later stages disease. Little data is available regarding predictive biomarkers for early, active cognitive decline relapse remitting MS (RRMS) patients. (2) Methods: 50 RRMS patients first 6 months following diagnosis were included. The minimum follow-up was one year. Biomarker samples collected at baseline, 3-, 6- and 12-month follow-up. performance assessed...
Intracerebral hemorrhage is a significant public health problem, as it disease associated with overwhelming mortality and disability. We performed retrospective feasibility study of patients admitted acute intracerebral in our department for four months. Our aims were to identify peculiarities the risk factors, demographic clinical characteristics from population, estimate feasible recruitment rate larger prospective analyze correct potential drawbacks methodology more extensive hospitalized...
Transient global amnesia is now considered a very rare complication of cerebral angiography. Various etiological mechanisms have been suggested to account for this complication, but no consensus has reached yet. This case report documents one the few reported cases angiography-related transient associated with magnetic resonance imaging (MRI) evidence unilateral hippocampal ischemia, most probably as consequence reduction in regional blood flow. However, possibility direct neurotoxic effect...
Abstract Cardiac abnormalities are frequently reported in acute subarachnoid hemorrhage (SAH) patients. However, frank ST-elevation and myocardial dysfunction mimicking coronary syndrome is a rare occurrence. Systemic local catecholamine release mediate injury may explain raised troponin levels, concordant regional wall motion systolic dysfunction. These findings can pose significant problem the setting where “time-is-muscle” paradigm rush clinicians towards “rule-in” diagnosis of...
Myasthenia gravis is an autoimmune disorder affecting neuromuscular transmission, and its hallmark fluctuating muscular weakness the ocular, bulbar, respiratory, or limb muscles. Our objective to highlight difficulties encountered in diagnosing this patients lacking characteristic phenomenon. Three cases of presenting with progressive bulbar ocular muscles, whom a lack fluctuation delayed diagnosis myasthenia gravis, are described. Amyotrophic lateral sclerosis was considered two patients,...
Background: The burden of stroke is high in Romania and data regarding access to post – rehabilitation are almost non–existent. We aimed determine the percentage patients who benefited from post–stroke describe most common settings. Methods: A structured telephone-based questionnaire therapy outcomes was administered all with ischemic reperfusion a tertiary center 2019. Results: 211 received during studied period. Out these, 208 were included initial analysis 109 deemed eligible for therapy....
Hypertrophic olivary degeneration after brainstem haemorrhage -A case report AbstrActInsidious neurological deterioration may develop months to years a lesion involving the Guillain-Mollaret triangle due hypertrophic degeneration.Lesions dento-rubro-olivary pathways lead pseudo-hypertrophy of inferior nucleus with subsequent neuronal degeneration.A number clinical syndromes have been linked degeneration.Cases gait ataxia, Holmes tremor and symptomatic palatal oculo-palatal were associated...
Objectives. The aim of our study is to determine whether cerebral vasomotor reactivity impaired in patients with arterial hypertension and cognitive impairment how this hemodynamic parameter associated different functions cognition. Materials methods. We included 87 divided into two groups, one neurocognitive ranging from mild severe aged between 47 90 years (70.2 ± 11.4) the second group without 41 86 (60.1 11.4). excluded significant cervico-cerebral stenoses, arrhythmias other diseases...
Romania has the highest prevalence of tuberculosis (TB) among all Central European countries. Involvement central nervous system (CNS) by TB accounts for approximately 1% cases tuberculosis. CNS includes two clinical categories: intracranial and spinal. We report meningitis with hemorrhagic CSF. Diagnosis was based on signs, complementary investigations response to early treatment antituberculosis medication adjunct steroid therapy. Some mild neurological sequels persisted.
Dysgenesia of the internal carotid artery (ICA) is a rare vascular congenital anomaly with variety different grades (agenesia, aplasia and hypoplasia). We report case 46 year old Caucasian women history asthma, who presented, 1 month after neck trauma in car accident, headache blurred vision left eye. Also, she described, intermittent weakness both hands (“she has been dropping objects”). Neurological examination was normal. Brain MRI showed no ischemic lesion, absence ICA, hypoplastic right...