Leonardo Renieri
A5050231752- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- COVID-19 and healthcare impacts
- Retinal and Optic Conditions
- Meningioma and schwannoma management
- Moyamoya disease diagnosis and treatment
- COVID-19 Clinical Research Studies
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Climate Change and Health Impacts
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and Diving-Related Complications
- Fetal and Pediatric Neurological Disorders
- Spinal Dysraphism and Malformations
Erasmus Hospital
2025
Pitié-Salpêtrière Hospital
2025
Sorbonne Université
2025
Azienda Ospedaliero-Universitaria Careggi
2015-2024
Boston Medical Center
2021-2022
Boston University
2021-2022
University of Florence
2017-2022
Neuroscience Institute
2022
Brigham and Women's Hospital
2022
Hospital de Clínicas de Porto Alegre
2021
The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide.We sought measure global impact on volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at height (1 March-31 May 2020) compared with two control periods (immediately preceding one year prior).Retrospective, observational, international study, across 6 continents, 40 countries, 187 comprehensive stroke centers. diagnoses were...
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Acute ischemic stroke (AIS) caused by distal medium vessel occlusions (DMVOs) represents a significant proportion of overall cases. While intravenous thrombolysis (IVT) has been primary treatment, advancements in endovascular procedures have led to increased use mechanical thrombectomy (MT) DMVO patients. However, symptomatic intracerebral hemorrhage (sICH) remains critical complication AIS, particularly after undergoing intervention. This study aims identify factors associated with sICH patients MT.
Background Blood blister aneurysms (BBA) are a rare subset of intracranial that represent therapeutic challenge from both surgical and endovascular perspective. Objective To report multicenter experience with flow diversion exclusively for BBA, located at non-branching segments along the anteromedial wall supraclinoidal internal carotid artery (ICA). Methods Consecutive cases BBA ICA treated were included in final analysis. Results 49 patients 51 devices to achieve effect identified. 43 45...
OBJECTIVE Flow diversion for posterior circulation aneurysms performed using the Pipeline embolization device (PED) constitutes an increasingly common off-label use otherwise untreatable aneurysms. The safety and efficacy of this treatment modality has not been assessed in a multicenter study. METHODS A retrospective review prospectively maintained databases at 8 academic institutions was years 2009 to 2016 identify patients with treated PED placement. RESULTS total 129 consecutive underwent...
Background and Purpose: Endovascular therapy for tandem occlusion strokes of the anterior circulation is an effective safe treatment. The best treatment approach cervical internal carotid artery (ICA) lesion still unknown. In this study, we aimed to compare functional safety outcomes between different approaches ICA during endovascular acute ischemic due in current clinical practice. Methods: Individual patients’ data were pooled from French prospective multicenter observational ETIS...
Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients distal medium vessel occlusions (DMVO) are not well understood.
Acute ischemic stroke (AIS) from primary medium vessel occlusions (MeVO) is a prevalent condition associated with substantial morbidity and mortality. Despite the common use of mechanical thrombectomy (MT) in AIS, predictors poor outcomes MeVO remain poorly characterized.
Background The combination of intravenous thrombolysis (IVT) with mechanical thrombectomy (MT) may have clinical benefits for patients medium vessel occlusion. Purpose To examine whether MT combined IVT is associated different outcomes than alone in acute ischemic stroke (AIS) and Materials Methods This retrospective study included consecutive adult AIS occlusion treated or at 37 academic centers North America, Asia, Europe. Data were collected from September 2017 to July 2021. Propensity...
Emergent carotid artery stenting plus mechanical thrombectomy is an effective treatment for acute ischemic stroke patients with tandem occlusion of the anterior circulation. However, there limited data supporting safety this approach in treated prior intravenous thrombolysis (IVT). We aimed to investigate emergent stenting-mechanical patient population IVT—We assessed because atherosclerotic that were from multicenter observational Thrombectomy Tandem Lesions registry. Patients divided into...
Background and Purpose— Antiplatelet agents could be used in the setting of endovascular therapy for tandem occlusions to reduce risk de novo intracranial embolic migration, reocclusion extracranial internal carotid artery lesion, or in-stent thrombosis case stent placement but have balanced with intracerebral hemorrhagic transformation risk. In this study, we aim investigate impact acute antiplatelet administration on outcomes during anterior circulation occlusions. Methods— This is a...
Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed nomogram predicting in patients with large vessel occlusion anterior circulation who received bridging intravenous thrombolysis (training set), validate model by using cohort treated direct (test set). Methods— We conducted study on prospectively collected data from 3714 enrolled IER (Italian Registry...
In patients with acute ischemic stroke treated reperfusion therapy we aimed to evaluate whether pretreatment blood-brain barrier (BBB) leakage is associated subsequent hemorrhagic transformation (HT).We prospectively screened intravenous thrombolysis and/or endovascular treatment. Before treatment, each patient received computed tomography (CT), CT angiography, and perfusion. We assessed BBB within the area using volume transfer constant (Ktrans ) value. Our primary outcome was relevant HT,...
During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study's objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations ruptured aneurysm coiling interventions demonstrated similar declines.We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries 140 comprehensive centres. Patients with diagnosis SAH, aneurysmal identified by prospective databases or International...
The mechanisms and outcomes in coronavirus disease (COVID-19)-associated stroke are unique from those of non-COVID-19 stroke.To describe the efficacy acute revascularization large vessel occlusion (LVO) setting COVID-19 an international cohort.We conducted multicenter retrospective study consecutively admitted patients with concomitant LVO across 50 comprehensive centers. Our control group constituted historical controls presenting receiving a mechanical thrombectomy between January 2018...
The management of acute ischemic stroke is changing. Over the period 2010-2050, number incident strokes expected to be more than double. Rapid access mechanical thrombectomy for patients with large vessel occlusion critically associated their functional outcome. Moreover, first pass effect had a better clinical outcome, lower mortality, and fewer procedural adverse events. We discuss some advances in regarding organization, diagnosis treatment.
Introduction: First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is significant predictor favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional and predictors FPE medium occlusions (MeVO) are scarce. Patients Methods: We conducted an international retrospective study MeVO cases. Multivariable logistic modeling was used to establish independent FPE. Clinical...
Background The Woven EndoBridge (WEB) device is frequently used for the treatment of intracranial aneurysms. Postoperative management, including use aspirin, varies among clinicians and institutions, but its impact on outcomes WEB has not been thoroughly investigated. Methods This was a retrospective, multicenter study involving 30 academic institutions in North America, South Europe. Data from 1492 patients treated with were included. Patients categorized into two groups based their...
Background and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed evaluate safety efficacy DMVO patients treated with either MT-IVT or alone.Methods multinational analyzed data from 37 centers across North America, Asia, Europe. Patients AIS were included, collected September 2017...
Despite the proven effectiveness of endovascular therapy (EVT) in acute ischemic strokes (AIS) involving anterior circulation large vessel occlusions, isolated posterior cerebral artery (PCA) occlusions (iPCAo) remain underexplored clinical trials. This study investigates comparative and safety EVT against medical management (MM) patients with iPCAo.
Background Current randomized controlled trials are investigating the efficacy and safety of mechanical thrombectomy (MT) in patients with medium vessel occlusion (MeVO) stroke. Whether best medical management (MM) is more efficient than unsuccessful recanalization during MT remains unknown. Methods This was a retrospective cohort study using data from 37 academic centers across North America, Asia, Europe between September 2017 July 2021. Only distal branches (M2 M3) middle cerebral artery...