A5102796764- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Long-Term Effects of COVID-19
- Omental and Epiploic Conditions
- Intracranial Aneurysms: Treatment and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 and healthcare impacts
- Peripheral Artery Disease Management
- COVID-19 Clinical Research Studies
- Retinal and Optic Conditions
- Venous Thromboembolism Diagnosis and Management
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Liver Disease Diagnosis and Treatment
Universidade de São Paulo
2012-2025
Hospital de Base
2020
Universidade de Ribeirão Preto
2015-2020
Fundação Faculdade de Medicina
2020
Clinics Hospital of Ribeirão Preto
2019
Universidade Brasil
2017
The effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion has not been well studied.We randomly assigned within 6 hours after the estimated time onset a due to occlusion, 1:1 ratio, receive or standard medical care. primary outcome was favorable functional outcome, defined as score 0 3 on modified Rankin scale (range, 6, indicating no disability, moderate and death) at 90 days. safety outcomes were symptomatic intracranial hemorrhage days initiation...
Randomized trials involving patients with stroke have established that outcomes are improved the use of thrombectomy for large-vessel occlusion. These were performed in high-resource countries and had limited effects on medical practice low- middle-income countries.
During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study's objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations ruptured aneurysm coiling interventions demonstrated similar declines.We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries 140 comprehensive centres. Patients with diagnosis SAH, aneurysmal identified by prospective databases or International...
ABSTRACT These guidelines are the result of a joint effort from writing groups Brazilian Stroke Society, Scientific Department Cerebrovascular Diseases Academy Neurology, Network and Society Diagnostic Therapeutic Neuroradiology. Members these participated in web-based discussion forums with predefined themes, followed by videoconference meetings which controversies position statements were discussed, leading to consensus. This focuses on implications recent clinical trials endovascular...
Background The RESILIENT trial demonstrated the clinical benefit of mechanical thrombectomy in patients presenting acute ischemic stroke secondary to anterior circulation large vessel occlusion Brazil. Aims This economic evaluation aims assess cost-utility from a public healthcare perspective. Methods A analysis was applied compare plus standard medical care (n = 78) vs. alone 73), subset sample (151 221 patients). Real-world direct costs were considered, and utilities imputed according...
Background RESILIENT is a prospective, multicenter, randomized phase III trial to test the safety, efficacy, and cost-effectiveness of mechanical thrombectomy as compared medical treatment alone in patients treated under less than ideal conditions typically found public healthcare system developing country. Methods Subjects must fulfill following main inclusion criteria: symptom onset ≤8 h, age ≥18 years, baseline NIHSS ≥8, evidence intracranial ICA or proximal MCA (M1 segment) occlusion,...
Introduction: Although the 2019 severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2, COVID-19) pandemic poses new challenges to healthcare system provide support for thousands of patients, there is special concern about common medical emergencies, such as stroke, that will continue occur and require adequate treatment. The allocation both material human resources fight cannot overshadow care a time-sensitive emergency with an inefficient treatment further increase mortality...
.First, these exciting results were obtained at high-volume comprehensive stroke centers with large ex -perience therapy TPA (including telemed-icine) and full-time teams (with a neurolo-gist), angiography suite multimodal neuroimaging. The reproducibility of their in our healthcare sys-tem requires organizing efficient networks, able to identify candidates for EVT promptly refer them care center. This poses special challenge Brazil, given its continental dimensions, geo-economical...
Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver that represents serious public health problem all over world, corresponding to third cause cancer death worldwide. The object was present clinical characteristics and follow-up patients with HCC attended at University Hospital Faculty Medicine Ribeirao Preto-USP (HCFMRP-USP), Preto, Sao Paulo, Brazil.Epidemiological data were revised from medical records.A total 130 participated in study, 81.5% them being males. Mean (±...
Background and purpose: RESILIENT Trial was the first study in a developing country to demonstrate benefit of mechanical thrombectomy (MT) acute stroke patients. This economic evaluation aimed access cost-utility MT under perspective Brazilian Public Healthcare System. Methods: Analysis based on subset sample original (151 221 patients) from 4 hospitals. We compared costs utilities between plus standard care (n=78) vs. alone (n=73). Direct medical were considered, inputted according each...
Introduction: In randomized clinical trials, central adjudication is frequently used for study outcomes. However, stroke trials have historically site-derived Rankin scale assessments as primary outcome. Hypothesis: A of assessment at least accurate assessment. Methods: We studied acute survivors from the RESILIENT study, where outcome was consensus rating two blinded adjudicators who independently watched video recordings a 90-day post-stroke structured patient and/or family interview....
Background: Mechanical thrombectomy (MT) in addition to intravenous thrombolysis (IVT) is now the recommended treatment for acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). The positive trials also demonstrated that MT alone among ineligible IVT an effective therapy AIS. Whether as effective, worse, or better than pretreatment before IVT-eligible AIS LVO debatable. We aimed assess effect of on clinical outcome RESILIENT trial. Methods: was a randomized, prospective,...
Background: The RESILIENT randomized trial of endovascular therapy for anterior circulation stroke within 8 hours symptom onset excluded subjects with poor collaterals. We analyzed the relationship CTA collateral grade respect to subsequent infarct growth over 24 hours, and without revascularization. Methods: independent imaging angiography core lab scored baseline Tan (0-3) CT ASPECTS scores at in both arms. ASITN (0-4) was adjudicated prior revascularization interventional arm. Descriptive...
Background: Randomized trials performed in high income countries have shown similar effects of mechanical thrombectomy (MT) elderly and non-elderly patients with large vessel ischemic strokes (LVO). We aimed to assess the effect age on clinical outcome MT RESILIENT (a randomized, prospective, multicenter, controlled, phase III, trial blinded assessment Brazil designed safety, efficacy, cost-effectiveness as compared medical treatment alone). Methods: Patients were classified (≤ 70 vs. >...