A5048422314- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Long-Term Effects of COVID-19
- Atrial Fibrillation Management and Outcomes
- COVID-19 and healthcare impacts
- Intracranial Aneurysms: Treatment and Complications
- Renal and Vascular Pathologies
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Retinal and Optic Conditions
- Cardiovascular and Diving-Related Complications
- Congenital Heart Disease Studies
- Neurological Disorders and Treatments
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Infrared Thermography in Medicine
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Advanced Neuroimaging Techniques and Applications
- Retinal Imaging and Analysis
- Neurological Disease Mechanisms and Treatments
Emory University
2016-2025
Emory University Hospital
2013-2025
Emory Healthcare
2014-2025
Kennesaw State University
2025
Arcadia
2024
Boston Medical Center
2021-2022
Boston University
2010-2022
Grady Memorial Hospital
2013-2022
Brookhaven College
2022
Hospital de Clínicas de Porto Alegre
2021
The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide.We sought measure global impact on volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at height (1 March-31 May 2020) compared with two control periods (immediately preceding one year prior).Retrospective, observational, international study, across 6 continents, 40 countries, 187 comprehensive stroke centers. diagnoses were...
Importance Atrial cardiopathy is associated with stroke in the absence of clinically apparent atrial fibrillation. It unknown whether anticoagulation, which has proven benefit fibrillation, prevents patients and no Objective To compare anticoagulation vs antiplatelet therapy for secondary prevention cryptogenic evidence cardiopathy. Design, Setting, Participants Multicenter, double-blind, phase 3 randomized clinical trial 1015 participants cardiopathy, defined as P-wave terminal force...
<h3>Objective:</h3> We sought to determine the relationship of greater adherence Mediterranean diet (MeD) and likelihood incident cognitive impairment (ICI) evaluate interaction race vascular risk factors. <h3>Methods:</h3> A prospective, population-based, cohort individuals enrolled in Reasons for Geographic Racial Differences Stroke (REGARDS) Study 2003–2007, excluding participants with history stroke, impaired status at baseline, missing data on Food Frequency Questionnaires (FFQ), was...
Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate severity of disease progression. We conducted a retrospective cohort analysis the medical records 268 adult patients, who were admitted to one six cohorted COVID ICUs across Emory Healthcare System had at least two values within first seven days admission study temporal progression its association all-cause in-hospital mortality. The median during hospitalization for entire was 130 mg/L (IQR...
Modified Rankin Scale (mRS) score 0-2 has been used to define "good outcome" while stroke patients with mRS 3 are grouped 4-6 as having "poor outcome." Long-term data comparing quality of life (QoL), particularly across the 2, 3, and 4 subgroups, sparse.Participants in Interventional Management Stroke (IMS3) trial documented 3-month mRS, functional disability (Barthel index [BI]), self-reported EQ5D-3L QoL questionnaires at months after were included. summary indices calculated using...
The pandemic caused by the novel coronavirus disease 2019 (COVID-19) has led to an unprecedented paradigm shift in medical care. We sought evaluate whether COVID-19 may have contributed delays acute stroke management at comprehensive centers.Pooled clinical data of consecutive adult patients from 14 US centers (January 1, 2019, July 31, 2020) were queried. rate thrombolysis for nontransferred within Target: Stroke goal 60 minutes was compared between admitted March and (pre-COVID-19), 2020,...
Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause which frequently cryptogenic. In large multinational cohort consecutive COVID-19 patients we evaluated clinical predictors cryptogenic short-term functional outcomes and in-hospital mortality among according to stroke etiology.We explored characteristics consecutively 18 years age or older acute ischemic (AIS) laboratory-confirmed from 31 hospitals in 4 countries...
Background. There is an increase in the incidence of type 2 diabetes children and adolescents. Absence known autoimmune markers sometimes required to confirm diagnosis. Objective. To identify clinical characteristics a pediatric population. Method. We report analysis 48 adolescents with diabetes, compared 39 randomly selected 1 diagnosed followed at Loma Linda University Pediatric Diabetes Center. Ethnic, familial, seasonal, marker are outlined. determine reliability antibody testing...
There are limited data on the relationship between patient and site characteristics clinical outcomes after intracranial stenting.We performed a multivariable analysis that correlated with occurrence of primary endpoint (any stroke or death within 30 days stenting in territory stented artery beyond days) 160 patients enrolled this registry. All presented an ischemic stroke, TIA, other cerebral event (e.g., vertebrobasilar insufficiency) suspected 50-99% stenosis major while antithrombotic...
The European Cooperative Acute Stroke Study (ECASS) III extended the thrombolysis time window for patients with stroke from 3 to 4.5 hours after symptom onset. We investigated effect of on proportion recombinant tissue-type plasminogen activator-treated and treatment initiation hospital arrival.The present study was based a prospective database 93 hospitals Register Northwestern Germany, which included 91 805 ischemic admitted between January 2007 December 2009. Main outcome measures were...
The coronavirus disease (COVID-19) pandemic has threatened millions of lives worldwide with severe systemic inflammation, organ dysfunction, and thromboembolic disease. Within our institution, many critically ill COVID-19-positive patients suffered major thrombotic events, prompting clinicians to evaluate hypercoagulability outside traditional coagulation testing.We determined the prevalence fibrinolysis shutdown via rotational thromboelastometry (ROTEM, Instrumentation Laboratories,...
To analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome.Multicentre retrospective cohort study patients AIS who presented to 30 centres in USA Canada between 14 March August 2020. The primary endpoint was poor outcome, defined as a modified Rankin Scale (mRS) 5 or 6 at discharge. Secondary endpoints include favourable outcome (mRS ≤2) mortality discharge, ordinal mRS (shift analysis), symptomatic intracranial...
<h3>BACKGROUND AND PURPOSE:</h3> Treatment strategies in acute ischemic stroke aim to curtail progression. Emerging paradigms propose patient subselection using imaging biomarkers derived from CT, CTA, and CT perfusion. We evaluated the performance of a fully-automated computational tool, hypothesizing enhancements compared with qualitative approaches. The correlation between variables clinical outcomes cohort patients is reported. <h3>MATERIALS METHODS:</h3> Sixty-two MCA or ICA occlusion...
Abstract Objective The objective of the present study was to examine relationship dietary fried fish consumption and risk cardiovascular events all-cause mortality. Design Prospective cohort among participants REasons for Geographic And Racial Differences in Stroke (REGARDS) who resided USA. Setting primary outcome measures included hazard ratios (HR) incident CVD including first fatal or non-fatal ischaemic stroke myocardial infarction mortality, based on cumulative average ascertained at...
There are limited data on the prevalence and prognosis of asymptomatic intracranial stenosis (AIS). Baseline cerebral angiograms MR were used to determine AIS (50% 99%) coexistent symptomatic for patients enrolled in Warfarin-Aspirin Symptomatic Intracranial Disease study. Coexisting detected 18.9% (n=14/74) undergoing 4-vessel angiography 27.3% (n=65/238) angiogram. During a mean follow-up period 1.8 years, no ischemic strokes attributable an 5 (5.9%, 95% CI: 2.1% 12.3%) occurred territory...
Pretreatment Alberta Stroke Program Early CT Scores (ASPECTS) is associated with clinical outcomes. The rate of decline between subsequent images, however, may be more predictive outcomes as it integrates time and physiology.A cohort patients transferred from six primary stroke centers treated intra-arterial therapy (IAT) was retrospectively studied. Absolute ASPECTS decay defined ((ASPECTS First CT-ASPECTS Second CT)/hours elapsed images). A logistic regression model performed to determine...
Clopidogrel is an antiplatelet drug that metabolized to its active form by the CYP2C19 enzyme. The CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) found a significant interaction between loss-of-function allele status for gene and effect of dual therapy with aspirin clopidogrel on rate early recurrent stroke following acute transient ischemic attack/minor stroke. POINT (Platelet-Oriented Inhibition New TIA Minor Ischemic Stroke Trial), similar...
In the setting of Coronavirus Disease 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association this disease with stroke has been suggested. We aimed to describe characteristics patients who were admitted COVID-19 and had an acute ischemic (AIS).This is case series PCR-confirmed academic health system in metropolitan Atlanta, Georgia (USA) between March 24th, 2020 July 17th, 2020. Demographic, clinical, radiographic described.Of 396 during study period, 13 (2.5%) also...
Background There is limited data on the markers of coagulation and hemostatic activation (MOCHA) profile in Coronavirus disease 2019 (COVID-19) its ability to identify COVID-19 patients at risk for thrombotic events other complications. Methods Hospitalized with confirmed SARS-COV-2 from four Atlanta hospitals were included this observational cohort study underwent admission testing MOCHA parameters (plasma d-dimer, prothrombin fragment 1.2, thrombin-antithrombin complex, fibrin monomer)....