Père-Joan Cardona
A5000283880- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Acute Ischemic Stroke Management
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Immune responses and vaccinations
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Poxvirus research and outbreaks
- Long-Term Effects of COVID-19
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Cell Function and Interaction
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Bacillus and Francisella bacterial research
- vaccines and immunoinformatics approaches
- SARS-CoV-2 detection and testing
- HIV Research and Treatment
Bellvitge University Hospital
2016-2025
Hospital Universitari Germans Trias i Pujol
2003-2025
Universitat Autònoma de Barcelona
2015-2024
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2015-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2015-2024
Instituto de Salud Carlos III
2008-2024
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2020-2024
Centre for Biomedical Network Research on Rare Diseases
2009-2023
Universitat de Barcelona
2023
Institut Pere Mata
2022
Tuberculosis (TB) is characterized by a tight interplay between Mycobacterium tuberculosis and host cells within granulomas. These cellular aggregates restrict bacterial spreading, but do not kill all the bacilli, which can persist for years. In-depth investigation of M. interactions with granuloma-specific cell populations are needed to gain insight into mycobacterial persistence, better understand physiopathology disease. We have analyzed formation foamy macrophages (FMs), population its...
Tuberculosis control relies on the identification and preventive treatment of individuals who are latently infected with Mycobacterium tuberculosis . However, direct latent infection is not possible. The diagnostic tests used to identify M. , in vivo tuberculin skin test ex interferon-γ release assays (IGRAs), designed an adaptive immune response against, but necessarily a with, proportion truly remain after or IGRA conversion unknown. It also uncertain how long responses towards...
An understanding of the trends in tuberculosis incidence, prevalence, and mortality is crucial to tracking success control programmes identification remaining challenges. We assessed fatal non-fatal burden over past 25 years for 195 countries territories.
Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aim To summarize the findings multinational observational cohort patients SARS-CoV-2 and cerebrovascular disease. Methods Retrospective consecutive adults evaluated emergency department and/or admitted coronavirus disease 2019 (COVID-19) across 31 hospitals four countries (1 February 2020–16 June 2020). The primary outcome was...
International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of direct oral anticoagulant (DOAC). To determine the risk symptomatic intracranial hemorrhage (sICH) associated use IVT DOAC ingestion. This international, multicenter, retrospective cohort study included 64 primary and comprehensive centers across Europe, Asia, Australia, New Zealand. Consecutive adult received (both without thrombectomy) were included....
Importance Whether endovascular thrombectomy (EVT) efficacy for patients with acute ischemic stroke and large cores varies depending on the extent of injury is uncertain. Objective To describe relationship between imaging estimates irreversibly injured brain (core) at-risk regions (mismatch) clinical outcomes EVT treatment effect. Design, Setting, Participants An exploratory analysis SELECT2 trial, which randomized 352 adults (18-85 years) due to occlusion internal carotid or middle cerebral...
C3HeB/FeJ mice infected with Mycobacterium tuberculosis were used in an experimental animal model mimicking active humans to evaluate the effect of antiinflammatory agents. No other treatment but ibuprofen was given, and it administered when animals' health started deteriorate. Animals treated had statistically significant decreases size number lung lesions, bacillary load, improvements survival, compared findings for untreated animals. Because agents are already on market, further clinical...
El estudio de la carga global las enfermedades, conocido como GBD por sus siglas en inglés (global burden of disease), mide salud poblacional todo el mundo forma anual y resultados están disponibles país. Utilizamos estimaciones para resumir estado España 2016 describir tendencias morbimortalidad 1990 a 2016. estima debida 333 enfermedades lesiones, 84 factores riesgo. La lista causas es jerárquica e incluye 3 categorías nivel superior: 1) transmisibles, maternas, neonatales nutricionales;...
Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages play inflammation, we studied contribution Mfn2 to activity these cells. Pro-inflammatory stimuli such as lipopolysaccharide (LPS) induced expression. The use Mfn1 myeloid-conditional knockout (KO) mouse models reveals but not is required for adaptation respiration stress conditions production reactive oxygen species (ROS) upon...
Objectives To evaluate the safety, tolerability and immunogenicity of three different doses (5, 25 50 µg) novel antituberculous vaccine RUTI compared to placebo in subjects with latent tuberculosis infection. Methods Findings Double-blind, randomized, placebo-controlled Phase II Clinical Trial (95 patients randomized). Three were tested, randomized both HIV-positive (n = 47) HIV-negative 48), after completion one month isoniazid (INH) pre-vaccination. Each subject received two...
The global burden of disease (GBD) project measures the health populations worldwide on an annual basis, and results are available by country. We used estimates GBD to summarise state in Spain 2016 report trends mortality morbidity from 1990 2016. estimated due 333 diseases injuries, 84 risk factors. list causes is hierarchical includes 3 top level categories, namely: (1) communicable, maternal, neonatal, nutritional diseases; (2) non-communicable (NCDs), (3) injuries. Mortality...
Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause which frequently cryptogenic. In large multinational cohort consecutive COVID-19 patients we evaluated clinical predictors cryptogenic short-term functional outcomes and in-hospital mortality among according to stroke etiology.We explored characteristics consecutively 18 years age or older acute ischemic (AIS) laboratory-confirmed from 31 hospitals in 4 countries...
Importance The role of endovascular thrombectomy is uncertain for patients presenting beyond 24 hours the time they were last known well. Objective To evaluate functional and safety outcomes (EVT) vs medical management in with large-vessel occlusion Design, Setting, Participants This retrospective observational cohort study enrolled between July 2012 December 2021 at 17 centers across United States, Spain, Australia, New Zealand. Eligible had occlusions internal carotid artery or middle...
Importance ApTOLL is a TLR4 antagonist with proven preclinical neuroprotective effect and safe profile in healthy volunteers. Objective To assess the safety efficacy of combination endovascular treatment (EVT) for patients ischemic stroke. Design, Setting, Participants This phase 1b/2a, double-blind, randomized, placebo-controlled study was conducted at 15 sites Spain France from 2020 to 2022. included aged 18 90 years who had stroke due large vessel occlusion were seen within 6 hours after...
Patients with large ischemic core stroke have poor clinical outcomes and are frequently not considered for interfacility transfer endovascular thrombectomy (EVT).
The aim of this study was to determine the prevalence and risk factors for lower airway bacterial colonization (LABC) in stable chronic bronchitis (CB). Forty-one outpatients with CB were enrolled (age 63.8+/-9.1 yrs (mean+/-SD); forced expiratory volume one second (FEV1)/forced vital capacity (FVC) 62.8+/-11.2; current/former smokers 24/17). All patients had normal chest radiographs an indication performing fibreoptic bronchoscopy (pulmonary nodule, remote haemoptysis). protected specimen...