Clara Suñer
A5015245388- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Bacillus and Francisella bacterial research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- SARS-CoV-2 detection and testing
- Infection Control and Ventilation
- Biosensors and Analytical Detection
- Immune cells in cancer
- Health disparities and outcomes
- Geriatric Care and Nursing Homes
- Adolescent Sexual and Reproductive Health
- Sexual function and dysfunction studies
- Vitamin C and Antioxidants Research
- Travel-related health issues
- Yersinia bacterium, plague, ectoparasites research
- Rabies epidemiology and control
- COVID-19 epidemiological studies
- Autophagy in Disease and Therapy
Manhiça Health Research Centre
2025
Universitat de Barcelona
2025
Barcelona Institute for Global Health
2025
Fundació Lluita contra les Infeccions
2020-2024
Hospital Universitari Germans Trias i Pujol
2022-2024
Universitat Autònoma de Barcelona
2023-2024
Fundació ACE
2024
Universitat de Vic - Universitat Central de Catalunya
2023
Red de Investigación en Sida
2023
Institute for Research in Biomedicine
2020-2022
<h2>Summary</h2><h3>Background</h3> In May, 2022, several European countries reported autochthonous cases of monkeypox, which rapidly spread globally. Early reports suggest atypical presentations. We aimed to investigate clinical and virological characteristics human monkeypox in Spain. <h3>Methods</h3> This multicentre, prospective, observational cohort study was done three sexual health clinics Madrid Barcelona, enrolled all consecutive patients with laboratory-confirmed from May 11 June...
No effective treatments for coronavirus disease 2019 (COVID-19) exist. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be efficacious outpatients COVID-19.Multicenter open-label, randomized, controlled trial conducted in Catalonia, Spain, between 17 March and 26 May 2020. Patients recently diagnosed <5-day of symptom onset were assigned receive HCQ (800 mg on day 1 followed by 400 once daily 6 days) or usual care. Outcomes reduction viral load nasopharyngeal...
BackgroundCurrent strategies for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited to nonpharmacologic interventions. Hydroxychloroquine has been proposed as a postexposure therapy prevent disease 2019 (Covid-19), but definitive evidence is lacking.MethodsWe conducted an open-label, cluster-randomized trial involving asymptomatic contacts of patients with polymerase-chain-reaction (PCR)–confirmed Covid-19 in Catalonia, Spain. We randomly assigned...
We investigated mechanisms of hepatic stellate cell (HSC) activation, which contributes to liver fibrogenesis. aimed determine whether activated HSCs increase glycolysis, is regulated by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3), and this pathway might serve as a therapeutic target.We performed studies with primary mouse HSCs, human LX2 cirrhotic tissues, rats mice fibrosis (due bile duct ligation [BDL] or administration carbon tetrachloride), CPEB4-knockout mice....
BackgroundThe increasing incidence of syphilis and the limitations first-line treatment with penicillin, particularly in neurosyphilis, neonatal syphilis, pregnancy, highlight need to expand therapeutic repertoire for effective management this disease. We assessed in-vitro efficacy 18 antibiotics from several classes on Treponema pallidum subspecies (T pallidum), bacteria.MethodsUsing culture system T pallidum, we exposed pathogen a concentration range each tested antibiotic. After 7-day...
Many countries have resumed mass-gathering events like music festivals, despite the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreading. In this study, we aimed to assess effect two outdoor events, held during a peak SARS-CoV-2 transmission, on COVID-19 incidence.This was retrospective, population-based control-matched analysis. The study population included attendees festivals in Catalonia (North-East Spain). primary objective compare incidence within 3-to-10 days...
Management of syphilis, a sexually transmitted infection (STI) with increasing incidence, is challenged by drug shortages, scarcity randomised trial data, an absence non-penicillin alternatives for pregnant women penicillin allergy (other than desensitisation), extended parenteral administration neurosyphilis and congenital macrolide resistance. Linezolid was shown to be active against Treponema pallidum, the causative agent in vitro rabbit model. We aimed assess efficacy linezolid treating...
ABSTRACT Background Current strategies for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are limited to non-pharmacological interventions. Hydroxychloroquine (HCQ) has been proposed as a postexposure therapy prevent Coronavirus disease 2019 (Covid-19) but definitive evidence is lacking. Methods We conducted an open-label, cluster-randomized trial including asymptomatic contacts exposed PCR-positive Covid-19 case in Catalonia, Spain. Clusters were...
Chronic inflammation is a major cause of disease. Inflammation resolution in part directed by the differential stability mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin (TTP)-directed mRNA deadenylation destabilizes AU-rich element (ARE)-containing mRNAs. However, this mechanism alone cannot explain variety expression kinetics that are required to uncouple degradation from sustained Here, we show RNA-binding protein CPEB4 acts an opposing manner...
The pathophysiology of viral diseases is complex, and often evokes strong inflammatory responses tissue damage. Currently available in vitro models mainly recapitulate the life cycle per se, but fail to model immune cell-mediated pathogenesis. Here we build macrophage-augmented organoids (MaugOs) by integrating macrophages into that are cultured from human liver tissues. We test infections two RNA viruses, hepatitis E virus (HEV) SARS-CoV-2, one DNA virus, monkeypox (MPXV), which either...
Background: The MVA-BN vaccine is considered effective for preventing mpox in key populations, based on observational studies, though its effectiveness remains unconfirmed by randomized trials. Observational studies published to date rely retrospective analyses of routine data, often missing information relevant risk factors mpox. Methods: Multi-country target trial emulation study with prospective data collection. Between September 1, 2022, and June 15, 2023, we recruited individuals...
Background:,Monkeypox DNA has been detected in skin lesions, saliva, oropharynx, urine, semen, and stool of patients infected during the 2022 outbreak; however, viral dynamics within these compartments remain unknown. We investigated clearance over course illness.Methods: This was an observational, prospective, multicentre study including individuals diagnosed with monkeypox hospitals sexual health clinics Spain. Participants collected swabs from their rectum, a dried blood spot, either...
We evaluated the accuracy of patient-collected skin lesions, oropharyngeal, and rectal swabs among 50 individuals enrolled in a study mpox viral dynamics. found that performance self-collected samples was similar to physician-collected samples, suggesting self-sampling is reliable strategy for diagnosing mpox.
The RNA binding protein CPEB2 defines a new posttranscriptional layer in the hormone-driven gene-expression reprogramming.
Upon tissue injury, cytokine expression reprogramming transiently remodels the inflammatory immune microenvironment to activate repair processes and subsequently return homeostasis. However, chronic inflammation induces permanent changes in production which exacerbate damage may even favor tumor development. Here, we address contribution of post-transcriptional regulation, by RNA-binding protein CPEB4, intestinal homeostasis its role bowel diseases (IBD) colorectal cancer (CRC) We found that...
Background Evidence on the determinants of magnitude humoral responses and neutralizing titers in individuals with mild COVID-19 is scarce. Methods In this cohort study patients, we assessed viral load (VL) by RT-qPCR at two/three time points during acute infection, anti-SARS-CoV-2 antibodies ELISA plasma using a pseudovirus assay day 60. Results Seventy-one (65% female, median 42 years old) were recruited grouped into high &gt;7.5 Log 10 copies/mL (n=20), low, VL ≤7.5 (n=22), or as...
Despite use of tecovirimat since the beginning 2022 outbreak, few data have been published on its antiviral effect in humans. We here predict efficacy using a unique set nonhuman primates (NHPs) and analyzed activity viral kinetics NHP to characterize concentration-effect relationship vivo. Next, we used pharmacological model developed healthy volunteers project Finally, dynamic was applied mpox skin lesions from 54 untreated patients, this modeling framework impact clearance lesions. At...