A5017665870- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Parasite Biology and Host Interactions
- Exercise and Physiological Responses
- Helminth infection and control
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Scarabaeidae Beetle Taxonomy and Biogeography
- Lipid metabolism and disorders
- Health and Lifestyle Studies
- RNA Research and Splicing
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Entomological Studies and Ecology
- Muscle metabolism and nutrition
- RNA modifications and cancer
- Orthoptera Research and Taxonomy
- Pregnancy and preeclampsia studies
- Mollusks and Parasites Studies
- Parasitic Diseases Research and Treatment
- Fossil Insects in Amber
- Apelin-related biomedical research
- Medicinal Plants and Bioactive Compounds
- Insects and Parasite Interactions
- Archaeological and Historical Studies
Universidad de León
2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2010-2021
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010-2021
Universitat de Barcelona
1993-2021
Instituto de Salud Carlos III
2020
Centre for Genomic Regulation
2010
Clínica Diagonal
1996
We investigated mechanisms of hepatic stellate cell (HSC) activation, which contributes to liver fibrogenesis. aimed determine whether activated HSCs increase glycolysis, is regulated by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3), and this pathway might serve as a therapeutic target.We performed studies with primary mouse HSCs, human LX2 cirrhotic tissues, rats mice fibrosis (due bile duct ligation [BDL] or administration carbon tetrachloride), CPEB4-knockout mice....
<h3>Objective</h3> Antiangiogenic strategies have been proposed as a promising new approach for the therapy of portal hypertension and chronic liver disease. Pigment epithelium-derived factor (PEDF) is powerful endogenous angiogenesis inhibitor whose role in remains unknown. Therefore, we aimed at determining involvement PEDF cirrhotic therapeutic efficacy its supplementation. <h3>Design</h3> expression profiling relationship with vascular endothelial growth (VEGF), neovascularisation...
Pathological angiogenesis represents a critical hallmark for chronic liver diseases. Understanding the mechanisms regulating is essential to develop new therapeutic strategies that specifically target pathological without affecting physiological angiogenesis. Here we investigated contribution and impact of endogenous angioinhibitor vasohibin-1 in portal hypertension cirrhosis. The spatiotemporal expression profiling its relationship with vascular endothelial growth factor (VEGF),...
Ductular reaction (DR) expands in chronic liver diseases and correlates with disease severity. Besides its potential role regeneration, DR plays a the wound-healing response of liver, promoting periductular fibrosis inflammatory cell recruitment. However, there is no information regarding intrahepatic angiogenesis. In current study we investigated contribution cells to hepatic vascular remodeling during disease.In mouse models injury, express genes involved Among angiogenesis-related genes,...
Obesity represents a growing health problem that is reaching pandemic dimensions and lacks effective cures, thus highlighting an urgent need for better mechanistic understanding new therapeutic strategies. Unlike transcription, the function of translation in obesity has hardly been investigated. Here, we fill this knowledge gap by pinpointing crucial gene regulation at step diet-induced obesity.We performed studies with human adipose tissue, high-fat-diet-induced obese mice rats,...
Objective Pathological neovascularisation is intimately involved in portal hypertension (PH). Here, we determined the contribution of vascular stem/progenitor cells (VSPCs) to neovessel growth PH and whether RNA-binding protein cytoplasmic polyadenylation element binding protein-4 (CPEB4) was behind mechanism controlling VSPC function. Design To identify monitor VSPCs rats (portal vein-ligated), used a combinatorial approach, including sphere-forming assay, assessment self-renewal,...
Deux enquêtes successives sur les vecteurs de Leishmania infantum, réalisées dans le Priorat (Catalogne, Espagne), ont permis la dissection 8 329 Phlébotomes ♀ dont 6 775 Larroussius (2 123 Phlebotomus ariasi et 4 652 P. perniciosus). Au total dix- huit souches été isolées chez ce même sous-genre rapportées, par l'analyse enzymatique, à L. infantum MON-1, MON-29, MON-77. Ces se répartissent entre (11 : quatre sept MON-29) perniciosus (sept un cinq MON-77). Par ailleurs chien, originaire du...
Development of portosystemic collateral vessels and gastroesophageal varices is responsible for the most serious clinical consequences portal hypertension, but effective therapies are limited. Here we developed investigated therapeutic potential an innovative liposomally-formulated short-interfering RNA (siRNA) technology based on stage components, capable to attenuate production endothelial kinase insert domain receptor (KDR), which controls collateralization contributes disease progression...
The authors have made the first discovery of Phlebotomus mascittii in Spain. species was caught Catalonia provinces Gerona and Barcelona. Altogether 7 individual sandflies (4 male, 3 female) were collected (using oiled paper traps) four separate sub-mediterranean sites (between 650 780 m).
A new Nematode Physalopteridae, Pseudophysaloptera kahmanni n. sp., parasitizing the stomach of dormouse Eliomys quercinus ophiusae Thomas, 1925 (Rodentia: Gliridae) in Formentera (Balearic Islands, Spain) is described. It first and only species genus Baylis, 1934 to be known Rodents nature.
Two gynandromorphic specimens of Phlebotomus perniciosus Newstead, 1911 are described and illustrated for the first time. The were collected in Northeast Iberian Peninsula (Spain).